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EXPERIMENTAL STUDY

Validation of in vivo myocardial strain measurement by magnetic resonance tagging with sonomicrometry

Susan B. Yeon, MD, FACC^*, Nathaniel Reichek, MD, FACC, Barbara A. Tallant, VMD, João A. C. Lima, MD, FACC, Linda P. Calhoun, MD, FACC, Neil R. Clark, MD, FACC, Eric A. Hoffman, PhD^||, Kalon K. L. Ho, MD, MSc, FACC^* and Leon Axel, PhD, MD ^¶

^* Cardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
Division of Cardiology, Department of Medicine, Allegheny General Hospital, Pittsburgh, Pennsylvania, USA
Cardiovascular Division, Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA
Cardiology Division, Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA
^|| Department of Radiology, University of Iowa College of Medicine, Iowa City, Iowa, USA
^¶ the Devon Imaging Center and Pendergrass Laboratory, Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA

Manuscript received November 7, 2000; revised manuscript received March 9, 2001, accepted April 25, 2001.

Reprint requests and correspondence: Dr. Susan B. Yeon, Cardiovascular Division, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, Massachusetts 02215
syeon{at}caregroup.harvard.edu

OBJECTIVES

This study was designed to validate strain measurements obtained using magnetic resonance tagging with spatial modulation of magnetization (SPAMM). We compared circumferential segment shortening measurements (%S) obtained using SPAMM to sonomicrometry %S in a canine model with (n = 28) and without (n = 3) coronary artery ligation.

BACKGROUND

Magnetic resonance tagging enables noninvasive measurement of myocardial strain, but such strain measurements have not yet been validated in vivo.

METHODS

Circumferential sonomicrometry crystal pairs were placed in apical myocardium at ischemic risk in ligation studies and in adjacent and remote myocardium. The %S was obtained from closely juxtaposed sonomicrometry and SPAMM sites.

RESULTS

Paired data were available from 19 of 31 studies. Both methods distinguished remote from ischemic function effectively (p = 0.014 for SPAMM and p = 0.002 for sonomicrometry). SPAMM %S was similar to sonomicrometry %S in ischemic myocardium (2 ± 3 vs. 0 ± 3, p = 0.067) but was slightly higher than sonomicrometry %S in remote myocardium (11 ± 10 vs. 7 ± 5, p = 0.033). End-systolic (n = 30) and late systolic (n = 34) SPAMM %S correlated well with sonomicrometry %S (r = 0.84, p < 0.0001 and r = 0.88, p < 0.0001).

CONCLUSIONS

Magnetic resonance tagging using SPAMM can quantitate myocardial strain in ischemic and remote myocardium. This study validates its application in scientific investigation and clinical assessment of patients with myocardial ischemia.

Abbreviations and Acronyms   %S = circumferential shortening measurement   ED = end-diastolic   ES = end-systolic   LS = late-systolic   MRI = magnetic resonance imaging   SPAMM = spatial modulation of magnetization

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