This Article Figures Only Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Kaji, S. Articles by Hu, B. S. Search for Related Content PubMed PubMed Citation Articles by Kaji, S. Articles by Hu, B. S.

CLINICAL STUDY: NEW METHODS

Rapid evaluation of left ventricular volume and mass without breath-holding using real-time interactive cardiac magnetic resonance imaging system

Shuichiro Kaji, MD^*, Philip C. Yang, MD^*, Adam B. Kerr, PhD, W. H. Wilson Tang, MD^*, Craig H. Meyer, PhD, Albert Macovski, PhD, John M. Pauly, PhD, Dwight G. Nishimura, PhD and Bob S. Hu, MD, FACC^*

^* Division of Cardiovascular Medicine, Department of Medicine, Stanford University, Stanford, California, USA
Magnetic Resonance Systems Research Laboratory, Department of Electrical Engineering, Stanford University, Stanford, California, USA

Manuscript received March 24, 2000; revised manuscript received January 16, 2001, accepted April 27, 2001.

Reprint requests and correspondence: Dr. Bob S. Hu, Division of Cardiovascular Medicine, Stanford University School of Medicine, Room H-2157, 300 Pasteur Drive, Stanford, California 94305-5233
hu{at}Isl.stanford.edu

OBJECTIVES

The purpose of this study was to validate cardiac measurements derived from real-time cardiac magnetic resonance imaging (MRI) as compared with well-validated conventional cine MRI.

BACKGROUND

Although cardiac MRI provides accurate assessment of left ventricular (LV) volume and mass, most techniques have been relatively slow and required electrocardiogram (ECG) gating over many heart beats. A newly developed real-time MRI system allows continuous real-time dynamic acquisition and display without cardiac gating or breath-holding.

METHODS

Fourteen healthy volunteers and nine patients with heart failure underwent real-time and cine MRI in the standard short-axis orientation with a 1.5T MRI scanner. Nonbreath-holding cine MRI was performed with ECG gating and respiratory compensation. Left ventricular end-diastolic volume (LVEDV), left ventricular endsystolic volume (LVESV), ejection fraction (EF) and LV mass calculated from the images obtained by real-time MRI were compared to those obtained by cine MRI.

RESULTS

The total study time including localization for real-time MRI was significantly shorter than cine MRI (8.6 ± 2.3 vs. 24.7 ± 3.5 min, p < 0.001). Both imaging techniques yielded good quality images allowing cardiac measurements. The measurements of LVEDV, LVESV, EF and LV mass obtained with real-time MRI showed close correlation with those obtained with cine MRI (LVEDV: r = 0.985, p < 0.001; LVESV: r = 0.994, p < 0.001; EF: r = 0.975, p < 0.001; LV mass: r = 0.977, p < 0.001).

CONCLUSIONS

Real-time MRI provides accurate measurements of LV volume and mass in a time-efficient manner with respect to image acquisition.

Abbreviations and Acronyms   EDV = end-diastolic volume   EF = ejection fraction   ESV = end-systolic volume   LV = left ventricle/left ventricular   MRI = magnetic resonance imaging

This article has been cited by other articles:

				V. Muthurangu, P. Lurz, J. D. Critchely, J. E. Deanfield, A. M. Taylor, and M. S. Hansen Real-time Assessment of Right and Left Ventricular Volumes and Function in Patients with Congenital Heart Disease by Using High Spatiotemporal Resolution Radial k-t SENSE Radiology, September 1, 2008; 248(3): 782 - 791. [Abstract] [Full Text] [PDF]

				M. Terashima, C. H. Meyer, B. G. Keeffe, E. J. Putz, E. de la Pena-Almaguer, P. C. Yang, B. S. Hu, D. G. Nishimura, and M. V. McConnell Noninvasive assessment of coronary vasodilation using magnetic resonance angiography J. Am. Coll. Cardiol., January 4, 2005; 45(1): 104 - 110. [Abstract] [Full Text] [PDF]

				K. Rajappan, N. G. Bellenger, G. Melina, M. Di Terlizzi, M. H. Yacoub, D. J. Sheridan, and D. J. Pennell Assessment of left ventricular mass regression after aortic valve replacement - cardiovascular magnetic resonance versus M-mode echocardiography Eur. J. Cardiothorac. Surg., July 1, 2003; 24(1): 59 - 65. [Abstract] [Full Text] [PDF]

				E. Spuentrup, J. Schroeder, A. H. Mahnken, T. Schaeffter, R. M. Botnar, H. P. Kuhl, P. Hanrath, R. W. Gunther, and A. Buecker Quantitative Assessment of Left Ventricular Function with Interactive Real-Time Spiral and Radial MR Imaging Radiology, June 1, 2003; 227(3): 870 - 876. [Abstract] [Full Text] [PDF]