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CLINICAL STUDY

Myocardial viability assessment by endocardial electroanatomic mapping: comparison with metabolic imaging and functional recovery after coronary revascularization

Karl-Christian Koch, MD^*, Juergen vom Dahl, MD, FESC^*, Monika Wenderdel^*, Bernd Nowak, MD, Wolfgang M. Schaefer, PhD, Alexander Sasse, MD^*, Christoph Stellbrink, MD^*, Udalrich Buell, MD and Peter Hanrath, MD, FACC, FESC^*

^* Medizinische Klinik I (Department of Cardiology), Aachen, Germany
Department of Nuclear Medicine, University Hospital, Aachen, Germany

Manuscript received October 23, 2000; revised manuscript received March 7, 2001, accepted March 26, 2001.

Reprint requests and correspondence: Dr. Jürgen vom Dahl, Medizinische Klinik I, Universitätsklinikum der RWTH Aachen, Pauwelstrasse 30, D-52057 Aachen, Germany
jvomdahl{at}post.klinikum.rwth-aachen.de

OBJECTIVES

The objective of this study was to compare electroanatomic mapping for the assessment of myocardial viability with nuclear metabolic imaging using positron emission computed tomography (PET) and with data on functional recovery after successful myocardial revascularization.

BACKGROUND

Animal experiments and first clinical studies suggested that electroanatomic endocardial mapping identifies the presence and absence of myocardial viability.

METHODS

Forty-six patients with prior (2 weeks) myocardial infarction underwent fluorine-18 fluorodeoxyglucose (FDG) PET and Tc-99m sestamibi single-photon emission computed tomography (SPECT) before mapping and percutaneous coronary revascularization. The left ventricular endocardium was mapped and divided into 12 regions, which were assigned to corresponding nuclear regions. Functional recovery using the centerline method was assessed in 25 patients with a follow-up angiography.

RESULTS

Regional unipolar electrogram amplitude was 11.0 mV ± 3.6 mV in regions with normal perfusion, 9.0 mV ± 2.8 mV in regions with reduced perfusion and preserved FDG-uptake and 6.5 mV ± 2.6 mV in scar regions (p < 0.001 for all comparisons). At a threshold amplitude of 7.5 mV, the sensitivity and specificity for detecting viable (by PET/SPECT) myocardium were 77% and 75%, respectively. In infarct areas with electrogram amplitudes >7.5 mV, improvement of regional wall motion (RWM) from –2.4 SD/chord ± 1.0 SD/chord to –1.5 SD/chord ± 1.1 SD/chord (p < 0.01) was observed, whereas, in infarct areas with amplitudes <7.5 mV, RWM remained unchanged at follow-up (–2.3 SD/chord ± 0.7 SD/chord to –2.4 SD/chord ± 0.7 SD/chord).

CONCLUSIONS

These data suggest that the regional unipolar electrogram amplitude is a marker for myocardial viability and that electroanatomic mapping can be used for viability assessment in the catheterization laboratory.

Abbreviations and Acronyms   AUC = area under the curve   CI = confidence interval   FDG = F-18 fluorodeoxyglucose   LAD = left anterior descending artery   LCX = left circumflex artery   LV = left ventricle or left ventricular   MI = myocardial infarction   PET = positron emission computed tomography   PTCA = percutaneous transluminal coronary angioplasty   RCA = right coronary artery   ROC = receiver operator curve   RWM = regional wall motion   SPECT = single photon emission computed tomography

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