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CLINICAL STUDY

Magnetic resonance phase-shift velocity mapping in pediatric patients with pulmonary venous obstruction

Neill Videlefsky, MD^*, W. James Parks, MD, John Oshinski, PhD, Katharine L. Hopkins, MD, Kevin M. Sullivan, PhD, MPH, MHA, Roderic I. Pettigrew, PhD, MD and Derek Fyfe, MD, PhD

^* Pediatric Cardiology Association, Atlanta, Georgia, USA
Sibley Heart Center Cardiology, Atlanta, Georgia, USA
Emory University School of Medicine, Atlanta, Georgia, USA
Children’s Health Care of Atlanta at Egleston Children’s Hospital, Atlanta, Georgia, USA

Manuscript received June 26, 1997; revised manuscript received March 6, 2001, accepted March 23, 2001.

Reprint requests and correspondence: Dr. James Parks, The Sibley Children’s Heart Center, Emory University, 2040 Ridgewood DT. N.E., Atlanta, GA 30322

OBJECTIVES

This study evaluated the accuracy, advantages and clinical efficacy of magnetic resonance (MR) phase-shift velocity mapping, in delineating the site and the hemodynamic severity of pulmonary venous (PV) obstruction in patients with congenital heart disease (CHD).

BACKGROUND

Magnetic resonance phase-shift velocity mapping of normal pulmonary veins and of obstructed PV pathways have been previously reported in a mainly adult population.

METHODS

The study population (33 pts) underwent MR phase-shift velocity mapping of their PV pathways. These results were compared with cardiac catheterization and Doppler echocardiography data.

RESULTS

The study population (0.4 to 19.5 years) consisted of a study group (PV pathway obstruction, n = 7) and a control group (no PV obstruction, n = 26). No patients had any left-to-right shunt lesions. The MR imaging displayed precise anatomical detail of the pulmonary veins. Phase velocities in the control group ranged from 20 to 71 cm/s, whereas velocities in the study group ranged from 100 to 250 cm/s (p = 0.002). The MR phase velocities (154 ± 0.53 cm/s) compared favorably with Doppler echocardiography (147 ± 0.54 cm/s), (r = 0.76; p = 0.05). The MR velocity mapping was 100% specific and 100% sensitive in detecting PV obstruction, although the absolute gradient measurements among MR phase mapping, echocardiographic Doppler and catheterization did not show statistically significant correlation.

CONCLUSIONS

In the absence of any associated left-to-right shunt lesions, PV velocities of 100 cm/s and greater indicated significant obstruction. The MR phase-shift velocity mapping, together with MR spin echocardiography and MR angiography, provides comprehensive anatomic and physiologic data that may obviate the need for further invasive studies.

Abbreviations and Acronyms   CHD = congenital heart disease   FFER = fast field "echo" real image   MR = magnetic resonance   PV = pulmonary venous   TEE = transesophageal echocardiography   TAPVR = total anomalous pulmonary venous return

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