|
| HOME | SUBSCRIPTIONS | CURRENT ISSUE | PAST ISSUES | CARDIOSOURCE | SEARCH | HELP | FEEDBACK |
|
|
|
|||||||||
|
|||||||||||
|
J Am Coll Cardiol, 2001; 38:26-32 © 2001 by the American College of Cardiology Foundation |
* Cardiology, Catholic University, Rome, Italy
Obstetrics and Gynecology, Catholic University, Rome, Italy
Division of Diabetology, Catholic University, Rome, Italy
Hormone Laboratory, Catholic University, Rome, Italy
Manuscript received October 26, 1999; revised manuscript received March 21, 2001, accepted April 6, 2001.
Reprint requests and correspondence: Dr. Elena Conti, Catholic University, Department of Cardiology, Largo Gemelli 8, 00168 Rome Italy
contielena{at}hotmail.com
OBJECTIVES
We investigated whether insulin-like growth factor-1 (IGF-1) is reduced in the early phase of acute myocardial infarction (AMI) and whether such a decrease might influence prognosis.
BACKGROUND
Insulin-like growth factor-1 protects against insulin resistance and apoptosis. Although insulin resistance has been reported in AMI, IGF-1 levels have not been investigated.
METHODS
We measured serum IGF-1 in 23 patients with AMI within 24 h of symptom onset and in 11 matched controls. In the first 12 patients and controls, we also measured fasting insulin, diurnal growth hormone (GH) and insulin sensitivity (assessed as glucose disappearance or T/2 after an insulin bolus), and repeated IGF-1, insulin and GH after one year. In all patients, 90-day cardiovascular death, recurrent ischemia, reinfarction, revascularization and late malignant arrhythmias were assessed.
RESULTS
The AMI patients versus controls showed markedly reduced IGF-1 (115 ± 112 vs. 615 ± 300 ng/ml, p < 0.0001) and slower T/2 (–0.98 ± 1.5 vs. –2.57 ± 1.0 mg/dl/min, p = 0.01). Low IGF-1 often preceded the rise of myocardial necrosis markers. Patients with 90-day events (n = 12) versus those without had lower IGF-1 (47 ± 54 vs. 189 ± 110 ng/ml, p < 0.0001). Acute phase GH and insulin concentrations did not differ significantly from controls. After one year, the patients’ IGF-1 values had risen to 460 ± 242 ng/ml (p = 0.1 vs. controls, p < 0.0005 vs. acute phase), whereas GH levels were lower (0.2 ± 0.2 vs. 2.5 ± 2.3 ng/ml, p = 0.01) and insulin levels higher (12.5 ± 0.2 vs. 3.9 ± 2.6 µU/ml, p < 0.0001) compared with controls.
CONCLUSIONS
In the early phase of AMI, serum IGF-1 levels are markedly reduced and may contribute to adverse outcomes. Reduced IGF-1 preceding the rise of myocardial necrosis markers suggests a possible pathogenetic role. A compensatory increase in IGF-1 appears to occur by one year.
| ||||||||||||||
This article has been cited by other articles:
|
|
 |
|
  F. Perticone, A. Sciacqua, M. Perticone, I. Laino, S. Miceli, I. Care', G. Galiano Leone, F. Andreozzi, R. Maio, and G. Sesti Low-Plasma Insulin-Like Growth Factor-I Levels Are Associated with Impaired Endothelium-Dependent Vasodilatation in a Cohort of Untreated, Hypertensive Caucasian Subjects J. Clin. Endocrinol. Metab., July 1, 2008; 93(7): 2806 - 2810. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Soeki, I. Kishimoto, D. O. Schwenke, T. Tokudome, T. Horio, M. Yoshida, H. Hosoda, and K. Kangawa Ghrelin suppresses cardiac sympathetic activity and prevents early left ventricular remodeling in rats with myocardial infarction Am J Physiol Heart Circ Physiol, January 1, 2008; 294(1): H426 - H432. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Hers Insulin-like growth factor-1 potentiates platelet activation via the IRS/PI3K{alpha} pathway Blood, December 15, 2007; 110(13): 4243 - 4252. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Bunda, P. Liu, Y. Wang, K. Liu, and A. Hinek Aldosterone Induces Elastin Production in Cardiac Fibroblasts through Activation of Insulin-Like Growth Factor-I Receptors in a Mineralocorticoid Receptor-Independent Manner Am. J. Pathol., September 1, 2007; 171(3): 809 - 819. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Saydah, B. Graubard, R. Ballard-Barbash, and D. Berrigan Insulin-like Growth Factors and Subsequent Risk of Mortality in the United States Am. J. Epidemiol., September 1, 2007; 166(5): 518 - 526. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. A. Marini, E. Succurro, S. Frontoni, M. L. Hribal, F. Andreozzi, R. Lauro, F. Perticone, and G. Sesti Metabolically Healthy but Obese Women Have an Intermediate Cardiovascular Risk Profile Between Healthy Nonobese Women and Obese Insulin-Resistant Women Diabetes Care, August 1, 2007; 30(8): 2145 - 2147. [Full Text] [PDF]
|
|
|
|
 |
|
 M. Yazdanpanah, F. A Sayed-Tabatabaei, J. A M J L Janssen, I. Rietveld, A. Hofman, T. Stijnen, H. A P Pols, S. W J Lamberts, J. C M Witteman, and C. M van Duijn IGF-I gene promoter polymorphism is a predictor of survival after myocardial infarction in patients with type 2 diabetes. Eur. J. Endocrinol., November 1, 2006; 155(5): 751 - 756. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. S. Johansson and H. J. Arnqvist Insulin and IGF-I action on insulin receptors, IGF-I receptors, and hybrid insulin/IGF-I receptors in vascular smooth muscle cells Am J Physiol Endocrinol Metab, November 1, 2006; 291(5): E1124 - E1130. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Efstratiadis, G. Tsiaousis, V. G. Athyros, D. Karagianni, A. Pavlitou-Tsiontsi, A. Giannakou-Darda, and C. Manes Total Serum Insulin-like Growth Factor-1 and C-Reactive Protein in Metabolic Syndrome With or Without Diabetes Angiology, May 1, 2006; 57(3): 303 - 311. [Abstract] [PDF]
|
|
|
|
 |
|
 S.-i. Kawachi, N. Takeda, A. Sasaki, Y. Kokubo, K. Takami, H. Sarui, M. Hayashi, N. Yamakita, and K. Yasuda Circulating Insulin-Like Growth Factor-1 and Insulin-Like Growth Factor Binding Protein-3 Are Associated With Early Carotid Atherosclerosis Arterioscler. Thromb. Vasc. Biol., March 1, 2005; 25(3): 617 - 621. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Sesti, A. Sciacqua, M. Cardellini, M. A. Marini, R. Maio, M. Vatrano, E. Succurro, R. Lauro, M. Federici, and F. Perticone Plasma Concentration of IGF-I Is Independently Associated With Insulin Sensitivity in Subjects With Different Degrees of Glucose Tolerance Diabetes Care, January 1, 2005; 28(1): 120 - 125. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Conti, C. Carrozza, E. Capoluongo, M. Volpe, F. Crea, C. Zuppi, and F. Andreotti Insulin-Like Growth Factor-1 as a Vascular Protective Factor Circulation, October 12, 2004; 110(15): 2260 - 2265. [Full Text] [PDF]
|
|
|
|
|
|
S. Suzuki, M. Yoshimura, M. Nakayama, Y. Mizuno, E. Harada, T. Ito, S. Nakamura, K. Abe, M. Yamamuro, T. Sakamoto, et al. Plasma Level of B-Type Natriuretic Peptide as a Prognostic Marker After Acute Myocardial Infarction: A Long-Term Follow-Up Analysis Circulation, September 14, 2004; 110(11): 1387 - 1391. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. A. Laughlin, E. Barrett-Connor, M. H. Criqui, and D. Kritz-Silverstein The Prospective Association of Serum Insulin-Like Growth Factor I (IGF-I) and IGF-Binding Protein-1 Levels with All Cause and Cardiovascular Disease Mortality in Older Adults: The Rancho Bernardo Study J. Clin. Endocrinol. Metab., January 1, 2004; 89(1): 114 - 120. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Dalla Libera, B. Ravara, M. Volterrani, V. Gobbo, M. Della Barbera, A. Angelini, D. D. Betto, E. Germinario, and G. Vescovo Beneficial effects of GH/IGF-1 on skeletal muscle atrophy and function in experimental heart failure Am J Physiol Cell Physiol, January 1, 2004; 286(1): C138 - C144. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. G. Dean, L. A. Bach, and L. M. Burrell Upregulation of Cardiac Insulin-like Growth Factor-I Receptor by ACE Inhibition After Myocardial Infarction: Potential Role in Remodeling J. Histochem. Cytochem., June 1, 2003; 51(6): 831 - 839. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Napoli, V. Guardasole, V. Angelini, F. D'Amico, E. Zarra, M. Matarazzo, and L. Sacca Acute Effects of Growth Hormone on Vascular Function in Human Subjects J. Clin. Endocrinol. Metab., June 1, 2003; 88(6): 2817 - 2820. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Mahmud and M. L. Vance Human Growth Hormone and Aging N. Engl. J. Med., May 29, 2003; 348(22): 2256 - 2257. [Full Text] [PDF]
|
|
|
|
|
|
M. T.B. Twickler, M.-J. M. Cramer, H. P.F. Koppeschaar, J. Malik, T. Stulc, R. Ceska, E. Conti, F. Crea, F. Andreotti, A. Juul, et al. Unraveling Reaven's Syndrome X: Serum Insulin-Like Growth Factor-I and Cardiovascular Disease * Response Circulation, May 27, 2003; 107 (20): e190 - e192. [Full Text] [PDF]
|
|
|
|
|
|
E. Conti, D. Pitocco, E. Capoluongo, C. Zuppi, G. Ghirlanda, F. Crea, and F. Andreotti IGF-1 and Macrovascular Complications of Diabetes: Alternative interpretations of recently published data Diabetes Care, May 1, 2003; 26(5): 1653 - 1654. [Full Text] [PDF]
|
|
| HOME | SUBSCRIPTIONS | CURRENT ISSUE | PAST ISSUES | CARDIOSOURCE | SEARCH | HELP | FEEDBACK |
