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CLINICAL STUDY

The adenosine triphosphate test: a bedside diagnostic tool for identifying the mechanism of supraventricular tachycardia in patients with palpitations

Sami Viskin, MD^*, Roman Fish, MD^*, Aharon Glick, MD^*, Michael Glikson, MD, FACC, Michael Eldar, MD, FACC and Bernard Belhassen, MD, FACC^*

^* Departments of Cardiology, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel
Sheba Medical Center, and the Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel

Manuscript received August 10, 1999; revised manuscript received March 5, 2001, accepted March 23, 2001.

Reprint requests and correspondence: Dr. Sami Viskin, Department of Cardiology, Tel-Aviv Sourasky Medical Center, Weizman Street 6, Tel-Aviv 64239, Israel
viskin_s{at}netvision.net.il

OBJECTIVES

This study assesses the value of the "ATP test" (injection of adenosine triphosphate [ATP] during sinus rhythm) for identifying patients with palpitations of unclear etiology who actually have atrioventricular (AV) nodal re-entry tachycardia (AVNRT) or AV re-entry tachycardia (AVRT).

BACKGROUND

Because AVNRT and AVRT can be cured with radiofrequency ablation, documentation of spontaneous AVNRT or AVRT usually prompts referral for electrophysiologic (EP) evaluation. However, these paroxysmal arrhythmias may elude clinical diagnosis. We recently showed that administration of ATP during sinus rhythm often reveals dual AV node physiology or a concealed accessory pathway (AP) in patients with documented AVNRT or AVRT. Thus, we postulated that the ATP test could identify patients with palpitations who actually have AVNRT or AVRT and would therefore benefit from EP evaluation.

METHODS

One hundred forty-six patients (54 with "palpitations without documented arrhythmias" and 92 with "documentation of arrhythmias of unclear mechanism") underwent a noninvasive ATP test. ATP was injected during sinus rhythm using 10 mg increments. The ATP test was considered positive when prospectively defined signs of dual AV node physiology or concealed AP were disclosed in the electrocardiogram. These findings were correlated with the results of EP evaluation.

RESULTS

A positive ATP test predicted induction of AVNRT or AVRT with a positive predictive value of 93% (sensitivity 71%) but a negative predictive value of 37% (specificity 76%).

CONCLUSIONS

A bedside ATP test identifies patients with palpitations who are likely to have AVNRT or AVRT (and who are therefore likely to benefit from EP evaluation) with a high positive predictive value.

Abbreviations and Acronyms   AP = accessory pathway   ATP = adenosine triphosphate   AVNRT = atrioventricular nodal re-entry tachycardia   AVRT = atrioventricular re-entry tachycardia   ECG = electrocardiograms   EP = electrophysiologic   NS = not statistically significant   RF = radiofrequency ablation

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