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J Am Coll Cardiol, 2001; 38:131-135 © 2001 by the American College of Cardiology Foundation |
* Department of Cardiothoracic Surgery and Anesthesiology, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden
Department of Cardiothoracic Surgery, University of Thessaly, Larissa, Greece
Manuscript received October 11, 2000; revised manuscript received March 15, 2001, accepted March 29, 2001.
Reprint requests and correspondence: Dr. Jan van der Linden, Department of Cardiothoracic Surgery and Anesthesiology, Karolinska Institutet, Huddinge University Hospital, SE-14186 Stockholm, Sweden
jan.vanderlinden{at}thsurg.hs.sll.se
OBJECTIVES
The aim of the study was to evaluate the risk from calcified atheromas in the ascending aorta, and the extent and topography of the disease in the development of stroke after cardiac surgery.
BACKGROUND
Postoperative stroke constitutes a serious problem in cardiac surgery, and atherosclerosis of the ascending aorta is an important risk factor.
METHODS
Before surgical manipulation epiaortic echocardiographic ultrasound was performed to evaluate the ascending aorta in 921 consecutive patients undergoing cardiac surgery. The presence of calcification, location of atheroma, extent of the disease and clinical variables including postoperative stroke were recorded prospectively.
RESULTS
A total of 26.2% of the patients had atherosclerosis of the ascending aorta, and in 44.4% of them more than one of 12 possible segments was involved. Logistic regression showed that atherosclerotic disease in the ascending aorta was the most important predictive factor for postoperative stroke. The incidence of stroke was 1.8% in patients without atherosclerotic disease of the ascending aorta, and 8.7% in patients with the disease (p < 0.0001). Diabetes mellitus was also a predictive factor (p = 0.04). A new and unique finding of this study was that the middle-lateral segment is an independent predictive factor for postoperative stroke, with a relative risk of 26% (p = 0.04).
CONCLUSIONS
Patients with atheromatosis in the ascending aorta had an 8.7% incidence of postoperative stroke, in spite of minor surgical modifications. The risk depended on the presence, location and extent of the disease. Randomized trials evaluating alternative surgical strategies in coronary surgery are urgently needed in high risk patients.
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