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CLINICAL STUDY: INTERVENTIONAL CARDIOLOGY

Achieving optimal results with standard balloon angioplasty: can baseline and angiographic variables predict stent-like outcomes?

Warren J. Cantor, MD^*, Anne S. Hellkamp, MS, Eric D. Peterson, MD, MPH, James P. Zidar, MD, Patricia A. Cowper, PhD, Michael H. Sketch, Jr, MD, James E. Tcheng, MD, Robert M. Califf, MD and E. Magnus Ohman, MD

^* St. Michael’s Hospital, Toronto, Canada
Duke Clinical Research Institute, Durham, North Carolina, USA

Manuscript received August 22, 2000; revised manuscript received January 30, 2001, accepted February 13, 2001.

Reprint requests and correspondence: Dr. Warren J. Cantor, St. Michael’s Hospital, Division of Cardiology, 30 Bond Street, Toronto, Ontario, Canada M5B 1W8.
cantorw{at}smh.toronto.on.ca

OBJECTIVES

To predict which patients might not require stent implantation, we identified clinical and angiographic characteristics associated with repeat revascularization after standard balloon angioplasty.

BACKGROUND

Stents reduce the risk of repeat revascularization but are costly and may lead to in-stent restenosis, which remains difficult to treat. Identification of patients at low risk for repeat revascularization may allow clinicians to reserve stents for patients most likely to benefit.

METHODS

Data from five interventional trials (5,146 patients) were pooled for analysis. We identified patients with optimal angiographic results (final diameter stenosis 30% and no dissection) after balloon angioplasty and determined the multivariable predictors of repeat revascularization.

RESULTS

Optimal angiographic results were achieved in 18% of patients after angioplasty. The repeat revascularization rate at six months was lower for patients with optimal results (20% vs. 26%, p < 0.001) but still higher than observed in stent trials. Independent predictors of repeat revascularization were female gender (odds ratio [OR] 1.67, p = 0.01), lesion length 10 mm (OR 1.62, p = 0.03) and proximal left anterior descending coronary artery lesions (OR 1.62, p = 0.03). For the 8% of patients with optimal angiographic results and none of these risk factors, the repeat revascularization and target vessel revascularization rates were 14% and 8% respectively, similar to rates after stent implantation. Cost analysis estimated that $78 million per year might be saved in the U.S. with a provisional stenting strategy using these criteria compared with elective stenting.

CONCLUSIONS

A combination of baseline characteristics and angiographic results can be used to identify a small group of patients at very low risk for repeat revascularization after balloon angioplasty. Provisional stenting for these low risk patients could substantially reduce costs without compromising clinical outcomes.

Abbreviations and Acronyms   BENESTENT = BElgium-NEtherlands Stent   CAVEAT = Coronary Angioplasty Versus Excisional Atherectomy Trial   CK-MB = creatine kinase-MB   EPIC = Evaluation of 7E3 for the Prevention of Ischemic Complications   EPISTENT = Evaluation of Platelet IIb/IIIa Inhibitor for Stenting   IMPACT II = Integrelin to Minimize Platelet Aggregation and Coronary Thrombosis II   LAD = left anterior descending coronary artery   MARCATOR = Multicenter American Research trial with Cilazapril after Angioplasty To prevent coronary Obstruction and Restenosis   MI = myocardial infarction   OPUS = Optimum Percutaneous transluminal coronary angioplasty compared with roUtine Stent   PBC = Perfusion Balloon Catheter study   QCA = quantitative coronary angiography   SLR = stent-like result   TVR = target vessel revascularization

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