CLINICAL STUDY: ACUTE CORONARY SYNDROME
Pre-infarction angina elicits greater myocardial viability on reperfusion after myocardial infarction: a dobutamine stress echocardiographic study
Ignacio Iglesias-Garriz, MDa,
F.élix Corral, MDa,
Miguel A. Rodríguez, MDa,
Carmen Garrote, MDa,
Manuela Montes, MDa and
Eugenia Sevillano, MDa
a Division of Cardiology, Hospital de León, León, Spain
Manuscript received July 24, 2000;
revised manuscript received January 24, 2001,
accepted February 12, 2001.
Reprint requests and correspondence: Dr. Ignacio Iglesias-Garriz, Division of Cardiology, Hospital de León, 24071 León, Spain med016340{at}nacom.es
OBJECTIVES
We sought to evaluate myocardial viability (inotropic reserve) after myocardial infarction (MI) and its relationship with the presence of unstable pre-infarction angina (PIA).
BACKGROUND
Several studies have suggested that PIA can limit infarct size, but it is not known whether PIA can elicit myocardial viability after an acute MI, with left ventricular function improvement.
METHODS
Before discharge from the hospital, 91 patients with a reperfused MI (either fibrinolysis or primary coronary angioplasty) had low-dose dobutamine echocardiography performed to assess the myocardial inotropic reserve of the infarct-related area.
RESULTS
Twenty-nine patients (31.9%) had PIA in the 24-h period before the onset of MI. Nine patients were treated with primary coronary angioplasty: five (8.1%) in the group with PIA and four (13.8%) in the group without PIA. There were no other significant differences in the baseline characteristics of the patients. There were more viable segments in patients with PIA (44.9% vs. 30.7%, p = 0.007), and the number of patients with significant viability was higher in the PIA group (73.9% vs. 46.3%, p = 0.026). This occurred despite a similar number of segments with segmental wall abnormalities at baseline in both groups (46.1% vs. 46.9%, p = NS).
CONCLUSIONS
The presence of previous unstable PIA induces greater myocardial viability of the infarct-related area upon reperfusion and, as such, could have considerable therapeutic and clinical implications.
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Abbreviations and Acronyms
| | CK-MB | = creatine kinase-MB fraction | | ECG | = electrocardiogram | | LDDE | = low-dose dobutamine echocardiography | | MI | = myocardial infarction | | PIA | = pre-infarction angina | | PIA+ | = presence of pre-infarction angina | | PIA | = absence of pre-infarction angina | | WMSI | = wall motion score index |
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I. Iglesias-Garriz, F. Fernandez-Vazquez, A. Perez, J. Jimenez-Bonilla, C. Garrote, P. Uriarte, and C. DelaFuente
Preinfarction Angina Limits Myocardial Infarction Size in Nondiabetic Patients Treated With Primary Coronary Angioplasty
Chest,
April 1, 2005;
127(4):
1116 - 1121.
[Abstract]
[Full Text]
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