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CLINICAL STUDY: ELECTROPHYSIOLOGY

Global distribution of atrial ectopic foci triggering recurrence of atrial tachyarrhythmia after electrical cardioversion of long-standing atrial fibrillation: a bi-atrial basket mapping study

^a Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan

Manuscript received June 13, 2000; revised manuscript received September 29, 2000, accepted November 10, 2000.

Reprint requests and correspondence: Dr. Jiunn-Lee Lin, Department of Internal Medicine, National Taiwan University Hospital, 7 Chun-Shan S. Road, Taipei, Taiwan, 100
jiunn{at}ha.mc.ntu.edu.tw

OBJECTIVES

The objective of this study was to assess the spatial distribution of atrial ectopic foci potentially triggering recurrent atrial tachyarrhythmias after electrical cardioversion of long-standing atrial fibrillation (AF).

BACKGROUND

It remains unknown whether targeted ablation of atrial ectopic foci concentrated in the pulmonary veins is feasible in patients with long-standing AF as it is in patients with paroxysmal AF.

METHODS

Two basket electrodes (32 bipoles on each eight splines) were positioned in the right and left atrium to identify the earliest endocardial activation sites of atrial ectopic foci emerging immediately after external electrical cardioversion of long-standing AF, before and after intravenous administration of dl-sotalol (16 patients) and propafenone (16 patients).

RESULTS

Before the use of antiarrhythmics, 91 distinct atrial ectopic foci were recognized after cardioversion. In 69 of the 91 foci, the earliest sites of presystolic atrial activation could be identified. Left atrial posterior (16 foci), left atrial anterior (11 foci) and right atrial posterior regions (13 foci) appeared to be prevalent. However, atrial ectopies from the remaining atrial regions (29 foci) were not uncommon. After adding dl-sotalol or propafenone, only 64 atrial ectopic foci were recognized after cardioversion; 50 of those were identifiable at the earliest activation sites. The scattered pattern of spatial distribution of the atrial ectopic foci was virtually unchanged.

CONCLUSIONS

Atrial ectopic foci potentially triggering the recurrence of atrial tachyarrhythmias after successful electrical cardioversion of long-standing AF were scattered in spatial distribution and multiple in production, possibly rendering difficult the targeted ablation approach.

Abbreviations and Acronyms   AF = atrial fibrillation   DC = direct current   ECG = electrocardiography   GEE = generalized estimating equation   Local A-A interval = Local atrial electrogram intervals

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