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CLINICAL STUDY: HYPERTENSION

Aldosterone synthase (CYP11B2) –344 C/T polymorphism is associated with left ventricular structure in human arterial hypertension

Christian Delles, MD^*, Jeanette Erdmann, PhD, Johannes Jacobi, MD^*, Karl F. Hilgers, MD^*, Eckart Fleck, MD, Vera Regitz-Zagrosek, MD and Roland E. Schmieder, MD, FACC^*

^* Department of Medicine/Nephrology, University of Erlangen, Nürnberg, Germany
Department of Medicine/Cardiology, Charité, Campus Virchow-Klinikum, Humboldt University and Deutsches Herzzentrum, Berlin, Germany

Manuscript received May 17, 2000; revised manuscript received September 25, 2000, accepted November 3, 2000.

Reprint requests and correspondence: Prof. Dr. med. Roland E. Schmieder, Universität Erlangen-Nürnberg, Medizinische Klinik IV/4, Klinikum Nürnberg Süd, Breslauer Strasse 201, 90471 Nürnberg, Germany
roland.schmieder{at}rzmail.uni-erlangen.de

OBJECTIVES

This study examined the association between the –344 C/T polymorphism of the human aldosterone synthase promoter and left ventricular structure in arterial hypertension.

BACKGROUND

Because of conflicting results from different studies, the mechanism of such an association, if any, has not been determined.

METHODS

We examined the aldosterone synthase promoter genotype in 120 young (age: 26 ± 3 years) male, white subjects with normal or mildly elevated blood pressure. Left ventricular structural parameters and urinary sodium excretion over 24 h before and after additional oral sodium load (6 g/day over 1 week) were determined.

RESULTS

Hypertensive subjects with the CC genotype had a greater left ventricular end-diastolic diameter but smaller relative wall thickness than those with the TT genotype (54 ± 2 vs. 50 ± 4 mm, and 0.37 ± 0.07 vs. 0.44 ± 0.06 mm, respectively; p < 0.05). Hypertensive subjects with the TT genotype (n = 15) had a greater increase in urinary sodium excretion after oral sodium load than those with the CC genotype (n = 11) (135 ± 95 vs. 24 ± 133 mmol/liter/day; p < 0.05). Serum aldosterone levels were found to be decreased after oral sodium load in hypertensive subjects with the TT and CT genotypes only (–37 ± 45 and –38 ± 51 pg/ml, respectively; all p < 0.01) but not in those with the CC genotype (–12 ± 30 pg/ml, n.s.). Such differences were not found in normotensive subjects.

CONCLUSIONS

Hypertensive subjects with the –344 CC genotype of the aldosterone synthase promoter are characterized by a pattern of early eccentric left ventricular hypertrophy. Differences in renal sodium handling across the genotypes might contribute to this finding.

Abbreviations and Acronyms   ASE = American Society for Echocardiography   LVM = left ventricular mass   PCR = polymerase chain reaction   WHO = World Health Organization

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