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EXPERIMENTAL STUDY

Validation of a digital color Doppler flow measurement method for pulmonary regurgitant volumes and regurgitant fractions in an in vitro model and in a chronic animal model of postoperative repaired tetralogy of Fallot

Yoshiki Mori, MD^*, Timothy Irvine, MD^*, Michael Jones, MD, Rosemary A. Rusk, MD^*, Quynh Pham, MS^*, Antoinette Kenny, MD and David J. Sahn, MD, FACC^*

^* Oregon Health Sciences University, Portland, Oregon, USA
the Laboratory of Animal Medicine and Surgery, National Heart, Lung and Blood Institute, Bethesda, Maryland, USA
Freeman Hospital, Newcastle upon Tyne, United Kingdom

Manuscript received January 10, 1999; revised manuscript received August 29, 2000, accepted October 4, 2000.

Reprint requests and correspondence: Dr. Michael Jones, Laboratory of Animal Medicine and Surgery, National Heart, Lung and Blood Institute, 9000 Rockville Place, Building 14E, Room 1074A, Bethesda, Maryland 20892

OBJECTIVES

The purpose of this study was to validate a digital color Doppler (DCD) automated cardiac flow measurement method for quantifying pulmonary regurgitation (PR) in an in vitro and a chronic animal model of the right ventricular outflow tract of postoperative tetralogy of Fallot (TOF).

BACKGROUND

There has been no reliable ultrasound method that can accurately quantitate PR.

METHODS

We developed an in vitro model of mild pulmonary stenosis and wide-open PR that mimics the patterns of flow seen in patients with postoperative TOF. Thirteen different forward and regurgitant stroke volumes (RSVs) across the noncircular shaped cross-sectional outflow tract flow area were estimated using the DCD method in two orthogonal planes. In six sheep with surgically created PR, 24 different hemodynamic states with PR strictly quantified by electromagnetic probes were also studied.

RESULTS

The RSVs and regurgitant fractions (RFs) obtained by the DCD method using average values from two orthogonal planes correlated well with reference values (RSV: r = 0.99, mean difference = 0.02 ± 0.39 ml/beat for in vitro model; r = 0.97, mean differences = 1.79 ± 1.84 ml/beat for animal model, RF: r = 0.98, mean difference = –1.10 ± 4.34% for in vitro model; r = 0.94, mean difference = 2.73 ± 6.75% for animal model). However, the DCD method using a single plane had limited accuracy for estimating pulmonary RFs and RSVs.

CONCLUSIONS

The DCD method using average values from two orthogonal planes provides accurate estimation of RSVs and RFs and should have clinical importance for serially quantifying PR in patients with postoperative TOF.

Abbreviations and Acronyms   ACM = automated cardiac flow measurement   DCD = digital color Doppler   EM = electromagnetic flow   FSV = forward stroke volume   MPA = main pulmonary artery   PR = pulmonary regurgitation   RF = regurgitant fraction   RSV = regurgitant stroke volume   RVOT = right ventricular outflow tract   TOF = tetralogy of Fallot

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