CLINICAL STUDY: ELECTROPHYSIOLOGY
Efficacy and safety of out-of-hospital self-administered single-dose oral drug treatment in the management of infrequent, well-tolerated paroxysmal supraventricular tachycardia
Paolo Alboni, MD, FACC*,
Corrado Tomasi, MD ,
Carlo Menozzi, MD,
Nicola Bottoni, MD,
Nelly Paparella, MD*,
Giuseppe Fucà, MD,
Michele Brignole, MD and
Riccardo Cappato, MD
* Division of Cardiology, Ospedale Civile, Cento (Fe), Italy
Section of Arrhythmology, Department of Cardiology, Ospedale S. Maria Nuova, Reggio Emilia, Italy
Section of Arrhythmology, Department of Cardiology, Ospedali Riuniti, Lavagna (Ge), Italy
Medizinische Abteilung, AK St. George, Hamburg, Germany
Manuscript received November 24, 1999;
revised manuscript received August 14, 2000,
accepted October 2, 2000.
Reprint requests and correspondence: Dr. Paolo Alboni, Division of Cardiology, Ospedale Civile, 44042 Cento (Fe), Italy
OBJECTIVES
We tested the efficacy of two drug treatments, flecainide (F) and the combination of diltiazem and propranolol (D/P), administered as a single oral dose for termination of the arrhythmic episodes.
BACKGROUND
Both prophylactic drug therapy and catheter ablation are questionable as first-line treatments in patients with infrequent and well-tolerated episodes of paroxysmal supraventricular tachycardia (SVT).
METHODS
Among 42 eligible patients (13% of all screened for SVT) with infrequent ( 5/year), well-tolerated and long-lasting episodes, 37 were enrolled and 33 had SVT inducible during electrophysiological study. In the latter, three treatments (placebo, F, and D/P) were administered in a random order 5 min after SVT induction on three different days.
RESULTS
Conversion to sinus rhythm occurred within 2 h in 52%, 61%, and 94% of patients on placebo, F and D/P, respectively (p < 0.001). The conversion time was shorter after D/P (32 ± 22 min) than after placebo (77 ± 42 min, p < 0.001) or F (74 ± 37 min, p < 0.001). Four patients (1 placebo, 1 D/P, and 2 F) had hypotension and four (3 D/P and 1 F) a sinus rate <50 beats/min following SVT interruption. Patients were discharged on a single oral dose of the most effective drug treatment (F or D/P) at time of acute testing. Twenty-six patients were discharged on D/P and five on F. During 17 ± 12 months follow-up, the treatment was successful in 81% of D/P patients and in 80% of F patients, as all the arrhythmic episodes were interrupted out-of-hospital within 2 h. In the remaining patients, a failure occurred during one or more episodes because of drug ineffectiveness or drug unavailability. One patient had syncope after D/P ingestion. During follow-up, the percentage of patients calling for emergency room assistance was significantly reduced as compared to the year before enrollment (9% vs. 100%, p < 0.0001).
CONCLUSIONS
The episodic treatment with oral D/P and F, as assessed during acute testing, appears effective in the management of selected patients with SVT. This therapeutic strategy minimizes the need for emergency room admissions during tachycardia recurrences.
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Abbreviations and Acronyms
| | AV | = atrioventricular | | D/P | = diltiazem and propranolol | | ECG | = electrocardiogram | | F | = flecainide | | SVT | = supraventricular tachycardia |
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