JACC
HOME SUBSCRIPTIONS CURRENT ISSUE PAST ISSUES CARDIOSOURCE SEARCH HELP FEEDBACK
QUICK SEARCH:   [advanced]


     

J Am Coll Cardiol, 2001; 37:386-391
© 2001 by the American College of Cardiology Foundation
This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Cheng, V.
Right arrow Articles by Maisel, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Cheng, V.
Right arrow Articles by Maisel, A.

CLINICAL STUDY: HEART FAILURE

A rapid bedside test for B-type peptide predicts treatment outcomes in patients admitted for decompensated heart failure: a pilot study

Van Cheng, BS*, Radmila Kazanagra, MD*, Alex Garcia, LVN*, Leslie Lenert, MD* {dagger}, Padma Krishnaswamy, MD*, Nancy Gardetto, NP*, Paul Clopton, BS* and Alan Maisel, MD, FACC* {dagger}

* Division of Cardiology, Veteran’s Affairs Medical Center, San Diego, California, USA
{dagger} Department of Medicine, University of California, San Diego, California, USA

Manuscript received April 27, 2000; revised manuscript received September 20, 2000, accepted October 26, 2000.

Reprint requests and correspondence: Dr. Alan Maisel, VAMC Cardiology 111-A, 3350 La Jolla Village Drive, San Diego, California 921161
amaisel{at}ucsd.edu

OBJECTIVES

The goal of this study was to determine if B-type natriuretic peptide (BNP) levels predict outcomes of patients admitted with decompensated heart failure.

BACKGROUND

Treatment of decompensated congestive heart failure (CHF) has often been based on titration of drugs to relieve patient’s symptoms, a case that could be made for attempting to also treat neurohormonal abnormalities. Because BNP reflects both elevated left ventricular pressure as well as neurohormonal modulation, we hypothesized that BNP might be useful in assessing outcomes in patients admitted with decompensated CHF.

METHODS

We followed 72 patients admitted with decompensated New York Heart Association class III to IV CHF, measuring daily BNP levels. We then determined the association between initial BNP measurement and the predischarge or premoribund BNP measurement and subsequent adverse outcomes (death and 30-day readmission).

RESULTS

Of the 72 patients admitted with decompensated CHF, 22 end points occurred (death: n = 13, readmission: n = 9). In these patients, BNP levels increased during hospitalization (mean increase, 233 pg/ml, p < 0.001). In patients without end points, BNP decreased (mean decrease 215 pg/ml). Univariate analysis revealed that the last measured BNP was strongly associated with the combined end point. In patients surviving hospitalization, BNP discharge concentrations were strong predictors of subsequent readmission (area under the receiver operator curve of 0.73).

CONCLUSIONS

In patients admitted with decompensated CHF, changes in BNP levels during treatment are strong predictors for mortality and early readmission. The results suggest that BNP levels might be used successfully to guide treatment of patients admitted for decompensated CHF.

Abbreviations and Acronyms
  BNP = B-type natriuretic peptide
  CHF = congestive heart failure
  LV = left ventricle, left ventricular
  NYHA = New York Heart Association
  SEM = standard error of the mean




This article has been cited by other articles:


Home page
 Arch Intern MedHome page
J. S. Ross, G. K. Mulvey, B. Stauffer, V. Patlolla, S. M. Bernheim, P. S. Keenan, and H. M. Krumholz
Statistical Models and Patient Predictors of Readmission for Heart Failure: A Systematic Review
Arch Intern Med, July 14, 2008; 168(13): 1371 - 1386.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
M. Nishii, T. Inomata, H. Takehana, T. Naruke, T. Yanagisawa, M. Moriguchi, S. Takeda, and T. Izumi
Prognostic utility of B-type natriuretic peptide assessment in stable low-risk outpatients with nonischemic cardiomyopathy after decompensated heart failure.
J. Am. Coll. Cardiol., June 17, 2008; 51(24): 2329 - 2335.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
S. W. Waldo, J. Beede, S. Isakson, S. Villard-Saussine, J. Fareh, P. Clopton, R. L. Fitzgerald, and A. S. Maisel
Pro-B-Type Natriuretic Peptide Levels in Acute Decompensated Heart Failure
J. Am. Coll. Cardiol., May 13, 2008; 51(19): 1874 - 1882.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
D. Stolz, T. Breidthardt, M. Christ-Crain, R. Bingisser, D. Miedinger, J. Leuppi, B. Mueller, M. Tamm, and C. Mueller
Use of B-Type Natriuretic Peptide in the Risk Stratification of Acute Exacerbations of COPD
Chest, May 1, 2008; 133(5): 1088 - 1094.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart JHome page
D. A. Pascual-Figal, M. Domingo, T. Casas, I. Gich, J. Ordonez-Llanos, P. Martinez, J. Cinca, M. Valdes, J. L. Januzzi, and A. Bayes-Genis
Usefulness of clinical and NT-proBNP monitoring for prognostic guidance in destabilized heart failure outpatients
Eur. Heart J., April 2, 2008; 29(8): 1011 - 1018.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
R. A. Rose and W. R. Giles
Natriuretic peptide C receptor signalling in the heart and vasculature
J. Physiol., January 15, 2008; 586(2): 353 - 366.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
L. B. Daniels and A. S. Maisel
Natriuretic Peptides
J. Am. Coll. Cardiol., December 18, 2007; 50(25): 2357 - 2368.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
S. von Haehling, E. A. Jankowska, N. G. Morgenthaler, C. Vassanelli, L. Zanolla, P. Rozentryt, G. S. Filippatos, W. Doehner, F. Koehler, J. Papassotiriou, et al.
Comparison of Midregional Pro-Atrial Natriuretic Peptide With N-Terminal Pro-B-Type Natriuretic Peptide in Predicting Survival in Patients With Chronic Heart Failure
J. Am. Coll. Cardiol., November 13, 2007; 50(20): 1973 - 1980.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
A. Maisel
Biomarkers in Heart Failure: Does Prognostic Utility Translate to Clinical Futility?
J. Am. Coll. Cardiol., September 11, 2007; 50(11): 1061 - 1063.
[Full Text] [PDF]

Home page
 HeartHome page
A M. Richards
Variability of NT-proBNP levels in heart failure: implications for clinical application
Heart, August 1, 2007; 93(8): 899 - 900.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
W.H. Wilson Tang, G. S. Francis, D. A. Morrow, L. K. Newby, C. P. Cannon, R. L. Jesse, A. B. Storrow, R. H. Christenson, COMMITTEE MEMBERS, R. H. Christenson, et al.
National Academy of Clinical Biochemistry Laboratory Medicine Practice Guidelines: Clinical Utilization of Cardiac Biomarker Testing in Heart Failure
Circulation, July 31, 2007; 116(5): e99 - e109.
[Full Text] [PDF]

Home page
 Eur Heart JHome page
F. M. Fruhwald, A. Fahrleitner-Pammer, R. Berger, F. Leyva, N. Freemantle, E. Erdmann, D. Gras, L. Kappenberger, L. Tavazzi, J.-C. Daubert, et al.
Early and sustained effects of cardiac resynchronization therapy on N-terminal pro-B-type natriuretic peptide in patients with moderate to severe heart failure and cardiac dyssynchrony
Eur. Heart J., July 1, 2007; 28(13): 1592 - 1597.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
G. C. Fonarow, W. F. Peacock, C. O. Phillips, M. M. Givertz, M. Lopatin, and for the ADHERE Scientific Advisory Committee and I
Admission B-Type Natriuretic Peptide Levels and In-Hospital Mortality in Acute Decompensated Heart Failure
J. Am. Coll. Cardiol., May 15, 2007; 49(19): 1943 - 1950.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
M. Cannesson, C. Bionda, B. Gostoli, O. Raisky, S. di Filippo, D. Bompard, C. Vedrinne, R. Rousson, J. Ninet, J. Neidecker, et al.
Time Course and Prognostic Value of Plasma B-type Natriuretic Peptide Concentration in Neonates Undergoing the Arterial Switch Operation
Anesth. Analg., May 1, 2007; 104(5): 1059 - 1065.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
P. Jourdain, G. Jondeau, F. Funck, P. Gueffet, A. Le Helloco, E. Donal, J. F. Aupetit, M. C. Aumont, M. Galinier, J. C. Eicher, et al.
Plasma Brain Natriuretic Peptide-Guided Therapy to Improve Outcome in Heart Failure: The STARS-BNP Multicenter Study
J. Am. Coll. Cardiol., April 24, 2007; 49(16): 1733 - 1739.
[Abstract] [Full Text] [PDF]

Home page
 EuropaceHome page
B. Naegeli, D. J. Kurz, D. Koller, E. Straumann, M. Furrer, D. Maurer, E. Minder, and O. Bertel
Single-chamber ventricular pacing increases markers of left ventricular dysfunction compared with dual-chamber pacing
Europace, March 1, 2007; 9(3): 194 - 199.
[Abstract] [Full Text] [PDF]

Home page
 Eur J EchocardiogrHome page
A. B. Scardovi, C. Coletta, N. Aspromonte, S. Perna, M. Greggi, P. D'Errigo, A. Sestili, and V. Ceci
Brain natriuretic peptide plasma level is a reliable indicator of advanced diastolic dysfunction in patients with chronic heart failure
Eur J Echocardiogr, January 1, 2007; 8(1): 30 - 36.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
A. Y.-M. Wang, C. W.-K. Lam, C.-M. Yu, M. Wang, I. H.-S. Chan, Y. Zhang, S.-F. Lui, and J. E. Sanderson
N-Terminal Pro-Brain Natriuretic Peptide: An Independent Risk Predictor of Cardiovascular Congestion, Mortality, and Adverse Cardiovascular Outcomes in Chronic Peritoneal Dialysis Patients
J. Am. Soc. Nephrol., January 1, 2007; 18(1): 321 - 330.
[Abstract] [Full Text] [PDF]

Home page
 Br J AnaesthHome page
A. Mekontso-Dessap, L. Tual, M. Kirsch, G. D'Honneur, D. Loisance, L. Brochard, and J.-L. Teboul
B-type natriuretic peptide to assess haemodynamic status after cardiac surgery
Br. J. Anaesth., December 1, 2006; 97(6): 777 - 782.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
M. Christ, K. Laule-Kilian, W. Hochholzer, T. Klima, T. Breidthardt, A. P. Perruchoud, and C. Mueller
Gender-Specific Risk Stratification With B-Type Natriuretic Peptide Levels in Patients With Acute Dyspnea: Insights From the B-type Natriuretic Peptide for Acute Shortness of Breath Evaluation Study
J. Am. Coll. Cardiol., November 7, 2006; 48(9): 1808 - 1812.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
J. F. Price, A. K. Thomas, M. Grenier, B. W. Eidem, E. O. Smith, S. W. Denfield, J. A. Towbin, and W. J. Dreyer
B-Type Natriuretic Peptide Predicts Adverse Cardiovascular Events in Pediatric Outpatients With Chronic Left Ventricular Systolic Dysfunction
Circulation, September 5, 2006; 114(10): 1063 - 1069.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
S.-C. Huang, E.-T. Wu, W.-J. Ko, L.-P. Lai, J. Hsu, C.-I. Chang, I.-S. Chiu, S.-S. Wang, M.-H. Wu, F.-Y. Lin, et al.
Clinical Implication of Blood Levels of B-Type Natriuretic Peptide in Pediatric Patients on Mechanical Circulatory Support
Ann. Thorac. Surg., June 1, 2006; 81(6): 2267 - 2272.
[Abstract] [Full Text] [PDF]

Home page
 HeartHome page
M. Weber and C. Hamm
Role of B-type natriuretic peptide (BNP) and NT-proBNP in clinical routine.
Heart, June 1, 2006; 92(6): 843 - 849.
[Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
A. Hirashiki, H. Izawa, F. Somura, K. Obata, T. Kato, T. Nishizawa, A. Yamada, H. Asano, S. Ohshima, A. Noda, et al.
Prognostic Value of Pacing-Induced Mechanical Alternans in Patients With Mild-to-Moderate Idiopathic Dilated Cardiomyopathy in Sinus Rhythm
J. Am. Coll. Cardiol., April 4, 2006; 47(7): 1382 - 1389.
[Abstract] [Full Text] [PDF]

Home page
 HeartHome page
G A Wright and A D Struthers
Natriuretic peptides as a prognostic marker and therapeutic target in heart failure
Heart, February 1, 2006; 92(2): 149 - 151.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
M. Richards, M. G. Nicholls, E. A. Espiner, J. G. Lainchbury, R. W. Troughton, J. Elliott, C. M. Frampton, I. G. Crozier, T. G. Yandle, R. Doughty, et al.
Comparison of B-Type Natriuretic Peptides for Assessment of Cardiac Function and Prognosis in Stable Ischemic Heart Disease
J. Am. Coll. Cardiol., January 3, 2006; 47(1): 52 - 60.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
P. G. Steg, L. Joubin, J. McCord, W. T. Abraham, J. E. Hollander, T. Omland, F. Mentre, P. A. McCullough, A. S. Maisel, and for the Breathing Not Properly Multinational Study
B-Type Natriuretic Peptide and Echocardiographic Determination of Ejection Fraction in the Diagnosis of Congestive Heart Failure in Patients With Acute Dyspnea
Chest, July 1, 2005; 128(1): 21 - 29.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart JHome page
D. Adlam, P. Silcocks, and N. Sparrow
Using BNP to develop a risk score for heart failure in primary care
Eur. Heart J., June 1, 2005; 26(11): 1086 - 1093.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
D. Detaint, D. Messika-Zeitoun, J.-F. Avierinos, C. Scott, H. Chen, J. C. Burnett Jr, and M. Enriquez-Sarano
B-Type Natriuretic Peptide in Organic Mitral Regurgitation: Determinants and Impact on Outcome
Circulation, May 10, 2005; 111(18): 2391 - 2397.
[Abstract] [Full Text] [PDF]

Home page
 AM J HOSP PALLIAT CAREHome page
M. P. Davis, N. M. Albert, and J. B. Young
Palliation of heart failure
American Journal of Hospice and Palliative Medicine, May 1, 2005; 22(3): 211 - 222.
[Abstract] [PDF]

Home page
 Eur Heart J SupplHome page
M. Gheorghiade and F. Zannad
Modern management of acute heart failure syndromes
Eur. Heart J. Suppl., April 1, 2005; 7(suppl_B): B3 - B7.
[Abstract] [Full Text] [PDF]

Home page
 BMJHome page
J. A Doust, E. Pietrzak, A. Dobson, and P. Glasziou
How well does B-type natriuretic peptide predict death and cardiac events in patients with heart failure: systematic review
BMJ, March 19, 2005; 330(7492): 625.
[Abstract] [Full Text] [PDF]

Home page
 PediatricsHome page
B. M. Choi, K. H. Lee, B. L. Eun, K. H. Yoo, Y. S. Hong, C. S. Son, and J. W. Lee
Utility of Rapid B-Type Natriuretic Peptide Assay for Diagnosis of Symptomatic Patent Ductus Arteriosus in Preterm Infants
Pediatrics, March 1, 2005; 115(3): e255 - e261.
[Abstract] [Full Text] [PDF]

Home page
 JAMAHome page
G. C. Fonarow, K. F. Adams Jr, W. T. Abraham, C. W. Yancy, W. J. Boscardin, and for the ADHERE Scientific Advisory Committee, Stud
Risk Stratification for In-Hospital Mortality in Acutely Decompensated Heart Failure: Classification and Regression Tree Analysis
JAMA, February 2, 2005; 293(5): 572 - 580.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart JHome page
R. Bassan, A. Potsch, A. Maisel, B. Tura, H. Villacorta, M. V. Nogueira, A. Campos, R. Gamarski, A. C. Masetto, and M. A. Moutinho
B-type natriuretic peptide: a novel early blood marker of acute myocardial infarction in patients with chest pain and no ST-segment elevation
Eur. Heart J., February 1, 2005; 26(3): 234 - 240.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
M. Vanderheyden, M. Goethals, S. Verstreken, B. De Bruyne, K. Muller, E. Van Schuerbeeck, and J. Bartunek
Wall stress modulates brain natriuretic peptide production in pressure overload cardiomyopathy
J. Am. Coll. Cardiol., December 21, 2004; 44(12): 2349 - 2354.
[Abstract] [Full Text] [PDF]

Home page
 Crit Care NurseHome page
N. M. Albert, C. A. Eastwood, and M. L. Edwards
Evidence-Based Practice for Acute Decompensated Heart Failure
Crit. Care Nurse, December 1, 2004; 24(6): 14 - 29.
[Full Text] [PDF]

Home page
 CirculationHome page
P. Bettencourt, A. Azevedo, J. Pimenta, F. Frioes, S. Ferreira, and A. Ferreira
N-Terminal-Pro-Brain Natriuretic Peptide Predicts Outcome After Hospital Discharge in Heart Failure Patients
Circulation, October 12, 2004; 110(15): 2168 - 2174.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart JHome page
A. Gackowski, R. Isnard, J.-L. Golmard, F. Pousset, A. Carayon, G. Montalescot, J.-S. Hulot, D. Thomas, W. Piwowarska, and M. Komajda
Comparison of echocardiography and plasma B-type natriuretic peptide for monitoring the response to treatment in acute heart failure
Eur. Heart J., October 2, 2004; 25(20): 1788 - 1796.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart JHome page
V. M. Conraads, P. Beckers, J. Vaes, M. Martin, V. Van Hoof, C. De Maeyer, N. Possemiers, F. L. Wuyts, and C. J. Vrints
Combined endurance/resistance training reduces NT-proBNP levels in patients with chronic heart failure
Eur. Heart J., October 2, 2004; 25(20): 1797 - 1805.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
A. Maisel, J. E. Hollander, D. Guss, P. McCullough, R. Nowak, G. Green, M. Saltzberg, S. R. Ellison, M. A. Bhalla, V. Bhalla, et al.
Primary results of the Rapid Emergency Department Heart Failure Outpatient Trial (REDHOT): A multicenter study of B-type natriuretic peptide levels, emergency department decision making, and outcomes in patients presenting with shortness of breath
J. Am. Coll. Cardiol., September 15, 2004; 44(6): 1328 - 1333.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
M. A. Bhalla, A. Chiang, V. A. Epshteyn, R. Kazanegra, V. Bhalla, P. Clopton, P. Krishnaswamy, L.K. Morrison, A. Chiu, N. Gardetto, et al.
Prognostic role of B-type natriuretic peptide levels in patients with type 2 diabetes mellitus
J. Am. Coll. Cardiol., September 1, 2004; 44(5): 1047 - 1052.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
R. J. Rodeheffer
Measuring plasma B-type natriuretic peptide in heart failure: Good to go in 2004?
J. Am. Coll. Cardiol., August 18, 2004; 44(4): 740 - 749.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
T. Nishikimi, H. Matsuoka, W.H. W. Tang, R. C. Starling, J. B. Young, G. S. Francis, J. P. Girod, M. J. Lee, and F. Van Lente
Plasma Brain Natriuretic Peptide Levels Indicate the Distance From Decompensated Heart Failure * Response
Circulation, June 29, 2004; 109(25): e329 - e330.
[Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
R. Hutfless, R. Kazanegra, M. Madani, M. A. Bhalla, A. Tulua-Tata, A. Chen, P. Clopton, C. James, A. Chiu, and A. S. Maisel
Utility of B-type natriuretic peptide in predicting postoperative complications and outcomes in patients undergoing heart surgery
J. Am. Coll. Cardiol., May 19, 2004; 43(10): 1873 - 1879.
[Abstract] [Full Text] [PDF]

Home page
 ANN INTERN MEDHome page
A. D. Auerbach and J. Kleinbart
Update in Hospital Medicine
Ann Intern Med, March 2, 2004; 140(5): 363 - 369.
[Full Text] [PDF]

Home page
 JCOHome page
S. E. Lipshultz and S. D. Colan
Cardiovascular Trials in Long-Term Survivors of Childhood Cancer
J. Clin. Oncol., March 1, 2004; 22(5): 769 - 773.
[Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
D. Logeart, G. Thabut, P. Jourdain, C. Chavelas, P. Beyne, F. Beauvais, E. Bouvier, and A. C. Solal
Predischarge B-type natriuretic peptide assay for identifying patients at high risk of re-admission after decompensated heart failure
J. Am. Coll. Cardiol., February 18, 2004; 43(4): 635 - 641.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
C. Mueller, A. Scholer, K. Laule-Kilian, B. Martina, C. Schindler, P. Buser, M. Pfisterer, and A. P. Perruchoud
Use of B-Type Natriuretic Peptide in the Evaluation and Management of Acute Dyspnea
N. Engl. J. Med., February 12, 2004; 350(7): 647 - 654.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
R. W. Troughton, D. L. Prior, J. J. Pereira, M. Martin, A. Fogarty, A. Morehead, T. G. Yandle, A. M. Richards, R. C. Starling, J. B. Young, et al.
Plasma B-type natriuretic peptide levels in systolic heart failure: importance of left ventricular diastolic function and right ventricular systolic function
J. Am. Coll. Cardiol., February 4, 2004; 43(3): 416 - 422.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart JHome page
M. M. Givertz and E. Braunwald
Neurohormones in heart failure: predicting outcomes, optimizing care
Eur. Heart J., February 2, 2004; 25(4): 281 - 282.
[Full Text] [PDF]

Home page
 ChestHome page
S. de Denus, C. Pharand, and D. R. Williamson
Brain Natriuretic Peptide in the Management of Heart Failure: The Versatile Neurohormone
Chest, February 1, 2004; 125(2): 652 - 668.
[Abstract] [Full Text] [PDF]

Home page
 Am J Crit CareHome page
A. Prahash and T. Lynch
B-Type Natriuretic Peptide: A Diagnostic, Prognostic, and Therapeutic Tool in Heart Failure
Am. J. Crit. Care., January 1, 2004; 13(1): 46 - 53.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
W.H. W. Tang, J. P. Girod, M. J. Lee, R. C. Starling, J. B. Young, F. Van Lente, and G. S. Francis
Plasma B-Type Natriuretic Peptide Levels in Ambulatory Patients With Established Chronic Symptomatic Systolic Heart Failure
Circulation, December 16, 2003; 108(24): 2964 - 2966.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
H. D. White and J. K. French
Use of brain natriuretic peptide levels for risk assessment in non-ST-elevation acute coronary syndromes
J. Am. Coll. Cardiol., December 3, 2003; 42(11): 1917 - 1920.
[Full Text] [PDF]

Home page
 Eur Heart JHome page
M.R Cowie, P Jourdain, A Maisel, U Dahlstrom, F Follath, R Isnard, A Luchner, T McDonagh, J Mair, M Nieminen, et al.
Clinical applications of B-type natriuretic peptide (BNP) testing
Eur. Heart J., October 1, 2003; 24(19): 1710 - 1718.
[Abstract] [Full Text] [PDF]

Home page
 Diabetes CareHome page
V. Epshteyn, K. Morrison, P. Krishnaswamy, R. Kazanegra, P. Clopton, S. Mudaliar, S. Edelman, R. Henry, and A. Maisel
Utility of B-Type Natriuretic Peptide (BNP) as a Screen for Left Ventricular Dysfunction in Patients With Diabetes
Diabetes Care, July 1, 2003; 26(7): 2081 - 2087.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
A. S. Maisel, J. McCord, R. M. Nowak, J. E. Hollander, A. H. B. Wu, P. Duc, T. Omland, A. B. Storrow, P. Krishnaswamy, W. T. Abraham, et al.
Bedside B-Type natriuretic peptide in the emergency diagnosis of heart failure with reduced or preserved ejection fraction: Results from the Breathing Not Properly Multinational Study
J. Am. Coll. Cardiol., June 4, 2003; 41(11): 2010 - 2017.