This Article Figures Only Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Tadamura, E. Articles by Konishi, J. Search for Related Content PubMed PubMed Citation Articles by Tadamura, E. Articles by Konishi, J.

CLINICAL STUDY: CORONARY PHYSIOLOGY

Comparison of myocardial blood flow during dobutamine-atropine infusion with that after dipyridamole administration in normal men

Eiji Tadamura, MD, PhD^*, Hidehiro Iida, PhD, Keiichi Matsumoto, RT^*, Marcelo Mamede, MD^*, Shigeto Kubo, MD^*, Hiroshi Toyoda, MD^*, Toshiki Shiozaki, MD^*, Takahiro Mukai, PhD^*, Yasuhiro Magata, PhD^* and Junji Konishi, MD, PhD^*

^* Department of Nuclear Medicine and Diagnostic Imaging, Kyoto University Graduate School of Medicine, Kyoto, Japan
Department of Radiology, National Cardiovascular Center, Suita, Japan

Manuscript received April 10, 2000; revised manuscript received July 11, 2000, accepted September 7, 2000.

Reprint requests and correspondence: Dr. Eiji Tadamura, Department of Nuclear Medicine and Diagnostic Imaging, Kyoto University Graduate School of Medicine, 54 Shogoinkawahara, Sakyo-ku, Kyoto, 606-8507, Japan
et{at}kuhp.kyoto-u.ac.jp

OBJECTIVES

The present study was designed to compare the absolute myocardial blood flow (MBF) after intravenous dipyridamole infusion with that during dobutamine-atropine administration in normal healthy male volunteers.

BACKGROUND

Both safety and usefulness of dobutamine-atropine stress in myocardial perfusion imaging have been reported. However, no information exists on whether the magnitude of hyperemia achieved with dipyridamole and dobutamine-atropine is comparable.

METHODS

Myocardial blood flow was measured with positron emission tomography and ¹⁵O-labeled water in 20 healthy young men (23 ± 3 years) 1) at baseline, 2) after dipyridamole infusion (0.56 mg/kg over 4 min), and 3) during dobutamine (40 µg/kg/min) and atropine (0.25 to 1.0 mg) infusion.

RESULTS

The MBF was significantly increased during dipyridamole infusion and during dobutamine–atropine stress compared with at rest (4.33 ± 1.23 and 5.89 ± 1.58 vs. 0.67 ± 0.16 ml/min/g, respectively, p < 0.0001). Moreover, dobutamine-atropine infusion produced greater MBF compared with dipyridamole (p = 0.0011), while coronary vascular resistance did not differ significantly after dipyridamole administration and during dobutamine-atropine infusion (17.6 ± 7.9 vs. 18.6 ± 5.6 mm Hg/[ml/min/g], respectively).

CONCLUSIONS

Near maximal coronary vasodilatation caused by dipyridamole is attainable using dobutamine and atropine in young healthy volunteers. Dobutamine in conjunction with atropine is no less effective than dipyridamole in producing myocardial hyperemia.

Abbreviations and Acronyms   BP = blood pressure   CAD = coronary artery disease   CVR = coronary vascular resistance   ECG = electrocardiogram   IV = intravenous   MBF = myocardial blood flow   PET = positron emission tomography   ROI = region of interest

This article has been cited by other articles:

				R. Gebker, C. Jahnke, R. Manka, A. Hamdan, B. Schnackenburg, E. Fleck, and I. Paetsch Additional Value of Myocardial Perfusion Imaging During Dobutamine Stress Magnetic Resonance for the Assessment of Coronary Artery Disease Circ Cardiovasc Imaging, September 1, 2008; 1(2): 122 - 130. [Abstract] [Full Text] [PDF]

				Y.-W. Wu, E. Tadamura, M. Yamamuro, S. Kanao, A. Marui, K. Tanabara, M. Komeda, and K. Togashi Comparison of Contrast-Enhanced MRI with 18F-FDG PET/201Tl SPECT in Dysfunctional Myocardium: Relation to Early Functional Outcome After Surgical Revascularization in Chronic Ischemic Heart Disease J. Nucl. Med., July 1, 2007; 48(7): 1096 - 1103. [Abstract] [Full Text] [PDF]

				A. Elhendy, A. F. Schinkel, J. J. Bax, and D. Poldermans Risk Stratification With Electrocardiographic-Gated Dobutamine Stress Imaging J. Am. Coll. Cardiol., October 3, 2006; 48(7): 1472 - 1472. [Full Text] [PDF]

				A. Elhendy, A. F.L. Schinkel, R. T. van Domburg, J. J. Bax, R. Valkema, E. Biagini, and D. Poldermans Prognostic Stratification of Obese Patients by Stress 99mTc-Tetrofosmin Myocardial Perfusion Imaging J. Nucl. Med., August 1, 2006; 47(8): 1302 - 1306. [Abstract] [Full Text] [PDF]

				A. Elhendy, A. F.L. Schinkel, R. T. van Domburg, J. J. Bax, R. Valkema, A. Huurman, H. H. Feringa, and D. Poldermans Risk Stratification of Patients with Angina Pectoris by Stress 99mTc-Tetrofosmin Myocardial Perfusion Imaging J. Nucl. Med., December 1, 2005; 46(12): 2003 - 2008. [Abstract] [Full Text] [PDF]

				A. Elhendy, A. Huurman, A. F.L. Schinkel, J. J. Bax, R. T. van Domburg, R. Valkema, E. Biagini, and D. Poldermans Association of Ischemia on Stress99mTc-Tetrofosmin Myocardial Perfusion Imaging with All-Cause Mortality in Patients with Diabetes Mellitus J. Nucl. Med., October 1, 2005; 46(10): 1589 - 1595. [Abstract] [Full Text] [PDF]

				S. Kubo, E. Tadamura, H. Toyoda, M. Mamede, M. Yamamuro, Y. Magata, T. Mukai, H. Kitano, N. Tamaki, and J. Konishi Effect of Caffeine Intake on Myocardial Hyperemic Flow Induced by Adenosine Triphosphate and Dipyridamole J. Nucl. Med., May 1, 2004; 45(5): 730 - 738. [Abstract] [Full Text] [PDF]

				E. Tadamura, M. Mamede, S. Kubo, H. Toyoda, M. Yamamuro, H. Iida, N. Tamaki, K. Nishimura, M. Komeda, and J. Konishi The Effect of Nitroglycerin on Myocardial Blood Flow in Various Segments Characterized by Rest-Redistribution Thallium SPECT J. Nucl. Med., May 1, 2003; 44(5): 745 - 751. [Abstract] [Full Text] [PDF]

				A. Elhendy, J. J. Bax, and D. Poldermans Dobutamine Stress Myocardial Perfusion Imaging in Coronary Artery Disease J. Nucl. Med., December 1, 2002; 43(12): 1634 - 1646. [Abstract] [Full Text] [PDF]

				G. Sakaguchi, E. Tadamura, M. Ohnaka, K. Tambara, K. Nishimura, and M. Komeda Composite arterial Y graft has less coronary flow reserve than independent grafts Ann. Thorac. Surg., August 1, 2002; 74(2): 493 - 496. [Abstract] [Full Text] [PDF]

				J.-P. Bin, R. A. Pelberg, K. Wei, D. E. Le, N. C. Goodman, and S. Kaul Dobutamine versus dipyridamole for inducing reversible perfusion defects in chronic multivessel coronary artery stenosis J. Am. Coll. Cardiol., July 3, 2002; 40(1): 167 - 174. [Abstract] [Full Text] [PDF]

				A. F.L. Schinkel, A. Elhendy, R. T. van Domburg, J. J. Bax, J. R.T.C. Roelandt, and D. Poldermans Prognostic Value of Dobutamine-Atropine Stress 99mTc-Tetrofosmin Myocardial Perfusion SPECT in Patients with Known or Suspected Coronary Artery Disease J. Nucl. Med., June 1, 2002; 43(6): 767 - 772. [Abstract] [Full Text] [PDF]

				R. Scognamiglio, A. Avogaro, S. Vigili de Kreutzenberg, C. Negut, M. Palisi, E. Bagolin, and A. Tiengo Effects of Treatment With Sulfonylurea Drugs or Insulin on Ischemia-Induced Myocardial Dysfunction in Type 2 Diabetes Diabetes, March 1, 2002; 51(3): 808 - 812. [Abstract] [Full Text] [PDF]