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CLINICAL STUDY: HYPERTROPHIC CARDIOMYOPATHY

Mitral regurgitation in hypertrophic obstructive cardiomyopathy: relationship to obstruction and relief with myectomy

^a Toronto General Hospital, University Health Network, University of Toronto, Toronto, Canada

Manuscript received December 8, 1999; revised manuscript received June 23, 2000, accepted August 11, 2000.

Reprint requests and correspondence: Dr. Eric Yu, Toronto Western Hospital, 399 Bathurst Street, EW5-559, Toronto, Ontario, Canada M5T 2S8
eric.yu{at}uhn.on.ca

OBJECTIVES

This study examined: 1) the impact of myectomy on postoperative mitral regurgitation (MR) and 2) the association between the severity of MR and the left ventricular outflow tract (LVOT) gradient.

BACKGROUND

For patients with hypertrophic obstructive cardiomyopathy (HOCM) and MR, controversy exists as to whether myectomy alone is sufficient in eliminating MR. Furthermore, the relationship between the degree of MR and the LVOT peak gradient has not been well defined.

METHODS

We performed pre- and postoperative transthoracic as well as intraoperative transesophageal studies in 104 consecutive patients with HOCM undergoing septal myectomy. Left ventricular outflow tract gradient and the nature of MR were assessed.

RESULTS

In the 93 patients without independent mitral valve disease, a relationship was observed between MR severity and the LVOT gradient. Left ventricular outflow tract gradient (mean ± standard deviation) for trivial, mild, moderate and severe MR were: 23.2 ± 19.1, 43.8 ± 25.4, 70.1 ± 21.0 and 104 ± 21.0 mm Hg (p < 0.001). Early postoperative, MR was absent or trivial in 80%, mild in 19% and moderate in 1%. None of these patients required additional mitral valve surgery. For patients with independent mitral valve disease (n = 11), five required mitral valve surgery as well as myectomy. The remainder had significant reductions in the degree of MR with myectomy alone.

CONCLUSIONS

For patients with HOCM and MR not due to independent mitral valve disease, myectomy significantly reduced the degree of MR, without requirement for additional mitral valve surgery. In these patients the severity of MR was directly related to the magnitude of the LVOT gradient.

Abbreviations and Acronyms   echo = echocardiography   HOCM = hypertrophic obstructive cardiomyopathy   LVOT = left ventricular outflow tract   MAC = mitral annulus calcification   MR = mitral regurgitation   MVP = mitral valve prolapse   SAM = systolic anterior motion   TEE = transesophageal echocardiography

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