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J Am Coll Cardiol, 2000; 36:1985-1991 © 2000 by the American College of Cardiology Foundation |
* Northwestern University Medical School Feinberg Cardiovascular Research Institute, Chicago, Illinois, USA
Department of Medicine, Chicago, Illinois, USA
Department of Pathology, Chicago, Illinois, USA
Department of Biomedical Engineering, Chicago, Illinois, USA
Manuscript received April 14, 2000; revised manuscript received May 23, 2000, accepted July 12, 2000.
Reprint requests and correspondence: Dr. Robert M. Judd, Feinberg Cardiovascular Research Institute, Northwestern University Medical School, 303 E Chicago Avenue, Tarry 12-723, Chicago, Illinois 60611-3008
rjudd{at}nwu.edu
OBJECTIVES
We sought to determine the relationship of delayed hyperenhancement by contrast magnetic resonance imaging (MRI) to viable and nonviable myocardium within the region at risk throughout infarct healing.
BACKGROUND
The relationship of delayed MRI contrast enhancement patterns to injured but viable myocardium within the ischemic bed at risk has not been established.
METHODS
We compared in vivo and ex vivo MRI contrast enhancement to histopathologic tissue sections encompassing the entire left ventricle in dogs (n = 24) subjected to infarction with (n = 12) and without (n = 12) reperfusion at 4 h, 1 day, 3 days, 10 days, 4 weeks and 8 weeks. In vivo MR imaging was performed 30 min after contrast injection.
RESULTS
The sizes and shapes of in vivo myocardial regions of elevated image intensity (828 ± 132% of remote) were the same as those observed ex vivo (241 slices, r = 0.99, bias = 0.05 ± 1.6% of left ventricle [LV]). Comparison of ex vivo MRI to triphenyltetrazolim chloride–stained sections demonstrated that the spatial extent of hyperenhancement was the same as the spatial extent of infarction at every stage of healing (510 slices, lowest r = 0.95, largest bias = 1.7 ± 2.9% of LV). Conversely, hyperenhanced regions were smaller than the ischemic bed at risk defined by fluorescent microparticles at every stage of healing (239 slices, 35 ± 24% of risk region, p < 0.001). Image intensities of viable myocardium within the risk region were the same as those of remote, normal myocardium (102 ± 9% of remote, p = NS).
CONCLUSIONS
Delayed contrast enhancement by MRI distinguishes between viable and nonviable regions within the myocardium at risk throughout infarct healing.
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