|
| HOME | SUBSCRIPTIONS | CURRENT ISSUE | PAST ISSUES | CARDIOSOURCE | SEARCH | HELP | FEEDBACK |
|
|
|
|||||||||
|
|||||||||||
|
J Am Coll Cardiol, 2000; 36:1063-1070 © 2000 by the American College of Cardiology Foundation |
* St. Luke’s–Roosevelt Hospital Center and Columbia University, New York, New York, USA
Vancouver Hospital & Science Center, Laurel Cardiology, Vancouver, British Columbia, Canada
New England Research Institutes, Watertown, Massachusetts, USA
CHR Citadelle, Department of Cardiology, Liège, Belgium
|| University of Alberta, Div. of Cardiology, Edmonton, Canada
¶ New York Cornell Medical Center, New York, New York, USA
Green Lane Hospital, Auckland, New Zealand
** Albert Einstein Medical Center (College of Medicine), New York, New York, USA
Manuscript received February 16, 2000; accepted March 17, 2000.
Request reprints and correspondence: Dr. Judith S. Hochman, St. Luke’s Roosevelt Hospital Center, 1111 Amsterdam Avenue, New York, New York 10025
OBJECTIVES
This SHOCK Study report seeks to provide an overview of patients with cardiogenic shock (CS) complicating acute myocardial infarction (MI) and the outcome with various treatments. The outcome of patients undergoing revascularization in the SHOCK Trial Registry and SHOCK Trial are compared.
BACKGROUND
Cardiogenic shock is the leading cause of death in patients hospitalized for acute MI. The randomized SHOCK Trial reported improved six-month survival with early revascularization.
METHODS
Patients with CS complicating acute MI who were not enrolled in the concurrent randomized trial were registered. Patient characteristics were recorded as were procedures and vital status at hospital discharge.
RESULTS
Between April 1993 and August 1997, 1,190 patients with CS were registered and 232 were randomized in the SHOCK Trial. Predominant left ventricular failure (78.5%) was most common, with isolated right ventricular shock in 2.8%, severe mitral regurgitation in 6.9%, ventricular septal rupture in 3.9% and tamponade in 1.4%. In-hospital Registry mortality was 60%, with ventricular septal rupture associated with a significantly higher mortality (87.3%) than all other categories (p < 0.01). The risk profile and mortality were lower for Registry patients who were managed with thrombolytic therapy and/or intra-aortic balloon counterpulsation, coronary angiography, angioplasty and/or coronary artery bypass surgery. After adjusting for these differences, the extent to which survival was improved with early revascularization was similar to that observed in the randomized SHOCK Trial.
CONCLUSIONS
In this prospective Registry the etiology of CS was a mechanical complication in 12%. The similarity of the beneficial treatment effect in patients undergoing early revascularization in the SHOCK Trial Registry and SHOCK Trial provides strong support for the generalizability of the SHOCK Trial results.
| ||||||||||||||||||||||
This article has been cited by other articles:
|
|
 |
|
  M. S. Lee, C.-H. Tseng, C. M. Barker, V. Menon, D. Steckman, R. Shemin, and J. S. Hochman Outcome after surgery and percutaneous intervention for cardiogenic shock and left main disease. Ann. Thorac. Surg., July 1, 2008; 86(1): 29 - 34. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Lorusso, S. Gelsomino, G. De Cicco, C. Beghi, C. Russo, M. De Bonis, A. Colli, and A. Sala Mitral valve surgery in emergency for severe acute regurgitation: analysis of postoperative results from a multicentre study Eur. J. Cardiothorac. Surg., April 1, 2008; 33(4): 573 - 582. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. R. Reynolds and J. S. Hochman Cardiogenic Shock: Current Concepts and Improving Outcomes Circulation, February 5, 2008; 117(5): 686 - 697. [Full Text] [PDF]
|
|
|
|
 |
|
 H. Thiele, R. W. Smalling, and G. C. Schuler Percutaneous left ventricular assist devices in acute myocardial infarction complicated by cardiogenic shock Eur. Heart J., September 1, 2007; 28(17): 2057 - 2063. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. P. Alexander, L. K. Newby, P. W. Armstrong, C. P. Cannon, W. B. Gibler, M. W. Rich, F. Van de Werf, H. D. White, W. D. Weaver, M. D. Naylor, et al. Acute Coronary Care in the Elderly, Part II: ST-Segment-Elevation Myocardial Infarction: A Scientific Statement for Healthcare Professionals From the American Heart Association Council on Clinical Cardiology: In Collaboration With the Society of Geriatric Cardiology Circulation, May 15, 2007; 115(19): 2570 - 2589. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. O. Bonow, B. A. Carabello, K. Chatterjee, A. C. de Leon Jr, D. P. Faxon, M. D. Freed, W. H. Gaasch, B. W. Lytle, R. A. Nishimura, P. T. O'Gara, et al. ACC/AHA 2006 Guidelines for the Management of Patients With Valvular Heart Disease: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 1998 Guidelines for the Management of Patients With Valvular Heart Disease) Developed in Collaboration With the Society of Cardiovascular Anesthesiologists Endorsed by the Society for Cardiovascular Angiography and Interventions and the Society of Thoracic Surgeons J. Am. Coll. Cardiol., August 1, 2006; 48(3): e1 - e148. [Full Text] [PDF]
|
|
|
|
|
|
R. O. Bonow, B. A. Carabello, K. Chatterjee, A. C. de Leon Jr, D. P. Faxon, M. D. Freed, W. H. Gaasch, B. W. Lytle, R. A. Nishimura, P. T. O'Gara, et al. ACC/AHA 2006 Practice Guidelines for the Management of Patients With Valvular Heart Disease: Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 1998 Guidelines for the Management of Patients With Valvular Heart Disease) Developed in Collaboration With the Society of Cardiovascular Anesthesiologists Endorsed by the Society for Cardiovascular Angiography and Interventions and the Society of Thoracic Surgeons J. Am. Coll. Cardiol., August 1, 2006; 48(3): 598 - 675. [Full Text] [PDF]
|
|
|
|
 |
|
 J. S. Hochman, L. A. Sleeper, J. G. Webb, V. Dzavik, C. E. Buller, P. Aylward, J. Col, H. D. White, and for the SHOCK Investigators Early revascularization and long-term survival in cardiogenic shock complicating acute myocardial infarction. JAMA, June 7, 2006; 295(21): 2511 - 2515. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. G. Leshnower, T. G. Gleason, M. L. O'Hara, A. Pochettino, Y. J. Woo, R. J. Morris, T. J. Gardner, and M. A. Acker Safety and Efficacy of Left Ventricular Assist Device Support in Postmyocardial Infarction Cardiogenic Shock Ann. Thorac. Surg., April 1, 2006; 81(4): 1365 - 1371. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Additional Information JAMA, March 15, 2006; 295(11): E7 - E14. [Full Text] [PDF]
|
|
|
|
|
|
R. V. Jeger, S. M. Harkness, K. Ramanathan, C. E. Buller, M. E. Pfisterer, L. A. Sleeper, J. S. Hochman, and for the SHOCK Investigators Emergency revascularization in patients with cardiogenic shock on admission: a report from the SHOCK trial and registry Eur. Heart J., March 2, 2006; 27(6): 664 - 670. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Migliorini and D. Antoniucci Patient selection bias in primary percutaneous coronary intervention trials: a critical issue Eur. Heart J. Suppl., October 1, 2005; 7(suppl_I): I21 - I26. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Babaev, P. D. Frederick, D. J. Pasta, N. Every, T. Sichrovsky, J. S. Hochman, and for the NRMI Investigators Trends in Management and Outcomes of Patients With Acute Myocardial Infarction Complicated by Cardiogenic Shock JAMA, July 27, 2005; 294(4): 448 - 454. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. S. Duvernoy and E. R. Bates Management of Cardiogenic Shock Attributable to Acute Myocardial Infarction in the Reperfusion Era J Intensive Care Med, July 1, 2005; 20(4): 188 - 198. [Abstract] [PDF]
|
|
|
|
|
|
H. Thiele, P. Sick, E. Boudriot, K.-W. Diederich, R. Hambrecht, J. Niebauer, and G. Schuler Randomized comparison of intra-aortic balloon support with a percutaneous left ventricular assist device in patients with revascularized acute myocardial infarction complicated by cardiogenic shock Eur. Heart J., July 1, 2005; 26(13): 1276 - 1283. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. P. Bouki, G. Pavlakis, and E. Papasteriadis Management of Cardiogenic Shock Due to Acute Coronary Syndromes Angiology, March 1, 2005; 56(2): 123 - 130. [Abstract] [PDF]
|
|
|
|
|
|
Endorsed by the European Society of Intensive Care, Authors/Task Force Members, M. S. Nieminen, M. Bohm, M. R. Cowie, H. Drexler, G. S. Filippatos, G. Jondeau, Y. Hasin, J. Lopez-Sendon, et al. Executive summary of the guidelines on the diagnosis and treatment of acute heart failure: The Task Force on Acute Heart Failure of the European Society of Cardiology Eur. Heart J., February 2, 2005; 26(4): 384 - 416. [Full Text] [PDF]
|
|
|
|
|
|
T. Ono, T. Asakura, T. Ohashi, and N. Ono A Simple Method of Triggering Balloon Counterpulsation Accurately During Off-Pump Coronary Artery Bypass Surgery Ann. Thorac. Surg., February 1, 2005; 79(2): 723 - 725. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Fincke, J. S. Hochman, A. M. Lowe, V. Menon, J. N. Slater, J. G. Webb, T. H. LeJemtel, G. Cotter, and SHOCK Investigators Cardiac power is the strongest hemodynamic correlate of mortality in cardiogenic shock: A report from the SHOCK trial registry J. Am. Coll. Cardiol., July 21, 2004; 44(2): 340 - 348. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. G. Pellizzon, C. L. Grines, D. A. Cox, T. Stuckey, J. E. Tcheng, E. Garcia, G. Guagliumi, M. Turco, A. J. Lansky, J. J. Griffin, et al. Importance of mitral regurgitation inpatients undergoing percutaneous coronaryintervention for acute myocardial infarction: The Controlled Abciximab and Device Investigation to Lower Late Angioplasty Complications (CADILLAC) Trial J. Am. Coll. Cardiol., April 21, 2004; 43(8): 1368 - 1374. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. W. Chen, J. G. Canto, L. S. Parsons, E. D. Peterson, K. A. Littrell, N. R. Every, C. M. Gibson, J. S. Hochman, E. M. Ohman, M. Cheeks, et al. Relation Between Hospital Intra-Aortic Balloon Counterpulsation Volume and Mortality in Acute Myocardial Infarction Complicated by Cardiogenic Shock Circulation, August 26, 2003; 108(8): 951 - 957. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. S. Hochman Cardiogenic Shock Complicating Acute Myocardial Infarction: Expanding the Paradigm Circulation, June 24, 2003; 107(24): 2998 - 3002. [Full Text] [PDF]
|
|
|
|
|
|
A. K. Jacobs, J. A. Leopold, E. Bates, L. A. Mendes, L. A. Sleeper, H. White, R. Davidoff, J. Boland, S. Modur, R. Forman, et al. Cardiogenic shock caused by right ventricular infarction: A report from the SHOCK registry J. Am. Coll. Cardiol., April 16, 2003; 41(8): 1273 - 1279. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. d. Graaf, M. Voskuil, and J. J. Piek Cardiogenic Shock Complicating an Acute Myocardial Infarction: Conservative Treatment Versus Revascularization Seminars in Cardiothoracic and Vascular Anesthesia, March 1, 2003; 7(1): 99 - 103. [PDF]
|
|
|
|
|
|
D.R Holmes The final common pathway Eur. Heart J., February 1, 2003; 24(3): 214 - 216. [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Birnbaum, M. C. Fishbein, C. Blanche, and R. J. Siegel Ventricular Septal Rupture after Acute Myocardial Infarction N. Engl. J. Med., October 31, 2002; 347(18): 1426 - 1432. [Full Text] [PDF]
|
|
|
|
|
|
H. Thiele, B. Lauer, R. Hambrecht, E. Boudriot, H. A. Cohen, and G. Schuler Reversal of Cardiogenic Shock by Percutaneous Left Atrial-to-Femoral Arterial Bypass Assistance Circulation, December 11, 2001; 104(24): 2917 - 2922. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M.S. Marber and S.R. Redwood The management of cardiogenic shock: can anything be learnt from registries? Eur. Heart J., March 2, 2001; 22(6): 444 - 445. [PDF]
|
|
|
|
|
|
L Carnendran, R Abboud, L.A Sleeper, R Gurunathan, J.G Webb, V Menon, V Dzavik, T Cocke, J.S Hochman, and for the SHOCK Investigators Trends in cardiogenic shock: report from the SHOCK Study Eur. Heart J., March 2, 2001; 22(6): 472 - 478. [Abstract] [PDF]
|
|
|
|
|
|
J. S. Hochman, L. A. Sleeper, H. D. White, V. Dzavik, S. C. Wong, V. Menon, J. G. Webb, R. Steingart, M. H. Picard, M. A. Menegus, et al. One-Year Survival Following Early Revascularization for Cardiogenic Shock JAMA, January 10, 2001; 285(2): 190 - 192. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. C. Wong, T. Sanborn, L. A. Sleeper, J. G. Webb, R. Pilchik, D. Hart, S. Mejnartowicz, T. A. Antonelli, R. Lange, J. K. French, et al. Angiographic findings and clinical correlates in patients with cardiogenic shock complicating acute myocardial infarction: a report from the SHOCK Trial Registry J. Am. Coll. Cardiol., September 1, 2000; 36(3_Suppl_A): 1077 - 1083. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. K. Jacobs, J. K. French, J. Col, L. A. Sleeper, J. N. Slater, L. Carnendran, J. Boland, X. Jiang, T. LeJemtel, J. S. Hochman, et al. Cardiogenic shock with non-ST-segment elevation myocardial infarction: a report from the SHOCK Trial Registry J. Am. Coll. Cardiol., September 1, 2000; 36(3_Suppl_A): 1091 - 1096. [Abstract] [Full Text] [PDF]
|
|
| HOME | SUBSCRIPTIONS | CURRENT ISSUE | PAST ISSUES | CARDIOSOURCE | SEARCH | HELP | FEEDBACK |
