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REVIEW ARTICLE

A perspective: the new millennium dawns on a new paradigm for cardiology—molecular genetics

^a Section of Cardiology, Baylor College of Medicine, Houston, Texas, USA

Manuscript received November 24, 1999; revised manuscript received April 1, 2000, accepted April 11, 2000.

Reprint requests and correspondence: Dr. Robert Roberts, Section of Cardiology, Baylor College of Medicine, 6550 Fannin, MS SM677, Houston, Texas 77030

Western civilization had two great epochs—the sixth century B.C. and the 18th century. The 21st century is likely to be the third great epoch. Although cardiology has advanced more in the last 50 years than in the previous 2,000, it is likely to advance more in the next two or three decades than in the previous 2,000 years, including those 50 golden years. The engines of ingenuity to provide the thrust for the 21th century will come from molecular genetics and the application of recombinant deoxyribonucleic acid (DNA) techniques. Identification of all human genes (50,000 to 100,000) in the next two to three years will help link thousands of etiologies and risk factors with their respective diseases, which represents a new paradigm in medicine. This is illustrated by the implications to be drawn from familial hypertrophic cardiomyopathy and the 50 new genes already identified to be responsible for cardiac disease. The hope for prevention and treatment of human disease is unprecedented. Twenty diseases account for 80% of the deaths in the Western world and are due to 100 to 200 genes, all of which will be available in a couple of years. The Phoenician alphabet (inclusive of the Greek vowels) of 26 letters launched two millenniums of Western civilization, whereas the DNA alphabet of only four letters will launch and dominate the next millennium.

Abbreviations and Acronyms   ACE = angiotensin-converting enzyme   ARVD = arrhythmogenic right ventricular dysplasia   AT-1 = angiotensin one   DNA = deoxyribonucleic acid   EST = expressed sequence   FDCM = familial dilated cardiomyopathy   FHCM = familial hypertrophic cardiomyopathy   HCM = hypertrophic cardiomyopathy