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CLINICAL STUDIES: ELECTROPHYSIOLOGY

Electrical behavior of T-Wave polarity alternans in patients with congenital long QT syndrome

^a Hospital Pró-Cardíaco, Rio de Janeiro, Brazil

Manuscript received December 7, 1998; revised manuscript received January 17, 2000, accepted March 6, 2000.

Reprint requests and correspondence: Dr. Fernando E. S. Cruz Fo, Avenue Canal de Marapendi 2500, Bloco 1, Apartment 503, Barra da Tijuca, Rio de Janeiro, CEP: 22.631-050 Brazil
fcruz{at}ax.apc.org

OBJECTIVES

This study was designed to evaluate the incidence and characteristics of onset of T-wave polarity alternans (TWPA) in patients with long QT syndrome.

BACKGROUND

The T-wave alternans is a phenomenon that consists of beat-to-beat variability in the amplitude, morphology, and sometimes polarity of the T-wave, and it may trigger life-threatening arrhythmias.

METHODS

The 24-h Holter recordings of 11 patients with congenital long QT syndrome were studied. Episodes of TWPA with 10 or more consecutive cycles were selected and analyzed as follows: 1) mean cycle length (MCL) and QTc interval duration (QTcI) of the episodes of TWPA and the 10 cycles preceding and succeeding the TWPA; 2) MCL and QTcI of the third, second, and first minute before onset (Mn_–3, Mn_–2, Mn_–1); 3) MCL and QTcI from the tenth to the first cycle immediately preceding the onset of TWPA (R_–10 to R_–1); 4) MCL and QTcI from the first to the fourteenth cycle during alternans (R₀ to R₁₄); 5) MCL and QTcI from the first to the tenth cycle immediately succeeding TWPA (R₊₁ to R₊₁₀); 6) linear correlation (Lnc) between QT interval and cycle length (CL) (LncQT/CL) during alternans and for the 10 preceding cycles; 7) Lnc between the first three alternans cycles and episode duration (Lnc 3CL/EpD); and 8) difference between the longest and shortest QTc interval. We also selected episodes consisting of four or more consecutive cycles in order to analyze daily rhythms of the phenomenon.

RESULTS

The TWPA was observed in 5 (45%) out of the 11 patients studied. The alternans process is initiated by a sudden shortening of the first alternans cycle without previous heart rate changes and ends at the moment when prolongation of the cycle tends to occur. LncQT/CL–alternans: r = 0.38 ± 0.2 (p = 0.20); without alternans: r = 0.81 ± 0.06 (p = 0.01). Lnc 3CL/EpD: r = 0.002 (p = 0.992). The QTc difference during alternans: 312.0 ± 52.1 ms; without alternans: 86.0 ± 36.4 ms (p = 0.001). Daily rhythm: 71% of the episodes occurred between 8 AM and 8 PM, with higher incidence during the morning.

CONCLUSIONS

The TWPA was dependent on the cardiac CL; there was loss of the LncQT/CL and an increase in the QT interval variability. Like other biological variables, T-wave polarity alternans has a higher density during the morning.

Abbreviations and Acronyms   CL = cycle length   CLQTS = congenital long QT syndrome   ECG = electrocardiogram   EpD = episode duration   Lnc = linear correlation   MCL = mean cycle length   QTcI = QTc interval duration   QTcVr = QTc interval variability   TWA = T-wave alternans   TWPA = T-wave polarity alternans

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