|
| HOME | SUBSCRIPTIONS | CURRENT ISSUE | PAST ISSUES | CARDIOSOURCE | SEARCH | HELP | FEEDBACK |
|
|
|
|||||||||
|
|||||||||||
|
J Am Coll Cardiol, 2000; 36:103-109 © 2000 by the American College of Cardiology Foundation |
,1
* MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, London, United Kingdom
Cardiology, University Hospital, Zürich, Switzerland
Manuscript received September 2, 1999; revised manuscript received December 30, 1999, accepted February 28, 2000.
Reprint requests and correspondence: Prof. Paolo G. Camici, MRC Cyclotron Unit, Hammersmith Hospital, London W12 ONN, United Kingdom
paolo.camici{at}csc.mrc.ac.uk
OBJECTIVES
The present study evaluates the impact of total cholesterol (TC) and its subfractions on coronary flow reserve (CFR), an index of the integrated function of the coronary circulation, in asymptomatic subjects.
BACKGROUND
Endothelial dysfunction of the coronary microcirculation has been reported in asymptomatic subjects with hypercholesterolemia.
METHODS
Using oxygen-15-labeled water and positron emission tomography, myocardial blood flow (MBF, in ml/min per g) was measured at rest and during intravenous adenosine (140 µg/kg body weight per min) in 80 asymptomatic nonsmoking men: group 1 (n = 61; age 45 ± 7 years) had normal TC (
6.5 mmol/liter or 250 mg/dl) and group 2 (n = 19; age 48 ± 10 years) had elevated TC.
RESULTS
Total cholesterol were 5.1 ± 0.8 and 7.2 ± 0.7 mmol/liter in groups 1 and 2 (p < 0.0005), respectively; low density lipoprotein (LDL) cholesterol levels were 3.2 ± 0.8 and 4.9 ± 0.7 mmol/liter (p < 0.0005); high density lipoprotein (HDL) cholesterol levels were 1.1 ± 0.3 and 1.0 ± 0.4 mmol/liter (p = NS); and triglyceride levels were 1.8 ± 1.3 and 3.0 ± 1.8 mmol/liter (p < 0.005). Groups 1 and 2 did not differ with regard to MBF at rest (0.87 ± 0.14 vs. 0.84 ± 0.14), MBF during adenosine (3.63 ± 1.02 vs. 3.30 ± 0.86) or CFR (4.23 ± 1.29 vs. 3.95 ± 0.93). A significant but weak correlation was found between CFR and HDL in group 1 (r = 0.29, p < 0.05), but not in group 2. In contrast, a significant inverse correlation between LDL and CFR was found in group 2 (r = –0.61, p < 0.05), but not in group 1.
CONCLUSIONS
Low density lipoprotein cholesterol but not TC correlated inversely with CFR in hypercholesterolemic subjects. Thus, LDL-induced coronary microvascular dysfunction could play an important role in the pathogenesis of coronary artery disease and its complications.
| ||||||||||||||||||
This article has been cited by other articles:
|
|
 |
|
  B. I. Levy, E. L. Schiffrin, J.-J. Mourad, D. Agostini, E. Vicaut, M. E. Safar, and H. A.J. Struijker-Boudier Impaired Tissue Perfusion: A Pathology Common to Hypertension, Obesity, and Diabetes Mellitus Circulation, August 26, 2008; 118(9): 968 - 976. [Full Text] [PDF]
|
|
|
|
 |
|
 H. A.J. Struijker-Boudier, A. E. Rosei, P. Bruneval, P. G. Camici, F. Christ, D. Henrion, B. I. Levy, A. Pries, and J.-L. Vanoverschelde Evaluation of the microcirculation in hypertension and cardiovascular disease Eur. Heart J., December 1, 2007; 28(23): 2834 - 2840. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Lewanczuk and P. W. Armstrong Physiologic Straws in the Wind: In Which Direction Do They Bend? J. Am. Coll. Cardiol., November 20, 2007; 50(21): 2059 - 2060. [Full Text] [PDF]
|
|
|
|
|
|
R. P. Naoumova, H. Kindler, L. Leccisotti, M. Mongillo, M. T. Khan, C. Neuwirth, M. Seed, P. Holvoet, J. Betteridge, and P. G. Camici Pioglitazone Improves Myocardial Blood Flow and Glucose Utilization in Nondiabetic Patients With Combined Hyperlipidemia: A Randomized, Double-Blind, Placebo-Controlled Study J. Am. Coll. Cardiol., November 20, 2007; 50(21): 2051 - 2058. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. A. Kaufmann, O. E. Rimoldi, T. Gnecchi-Ruscone, T. F. Luscher, and P. G. Camici Systemic nitric oxide synthase inhibition improves coronary flow reserve to adenosine in patients with significant stenoses Am J Physiol Heart Circ Physiol, October 1, 2007; 293(4): H2178 - H2182. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. G. Camici and F. Crea Coronary Microvascular Dysfunction N. Engl. J. Med., February 22, 2007; 356(8): 830 - 840. [Full Text] [PDF]
|
|
|
|
 |
|
 J J Bax, R S Beanlands, F J Klocke, J Knuuti, A A Lammertsma, M A Schaefers, H R Schelbert, G K Von Schulthess, L J Shaw, G Z Yang, et al. Diagnostic and clinical perspectives of fusion imaging in cardiology: is the total greater than the sum of its parts? Heart, January 1, 2007; 93(1): 16 - 22. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. van der Harst, A. A. Voors, W. H. van Gilst, M. Bohm, and D. J. van Veldhuisen Statins in the treatment of chronic heart failure: Biological and clinical considerations Cardiovasc Res, August 1, 2006; 71(3): 443 - 454. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Gronros, J. Wikstrom, U. Hagg, B. Wandt, and L.-m. Gan Proximal to Middle Left Coronary Artery Flow Velocity Ratio, As Assessed Using Color Doppler Echocardiography, Predicts Coronary Artery Atherosclerosis in Mice Arterioscler. Thromb. Vasc. Biol., May 1, 2006; 26(5): 1126 - 1131. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Topcu, M. Caliskan, E. E. Ozcimen, D. Tok, A. Uckuyu, D. Erdogan, H. Gullu, A. Yildirir, H. Zeyneloglu, and H. Muderrisoglu Do young women with polycystic ovary syndrome show early evidence of preclinical coronary artery disease? Hum. Reprod., April 1, 2006; 21(4): 930 - 935. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Namdar, P. Koepfli, R. Grathwohl, P. T. Siegrist, M. Klainguti, T. Schepis, R. Delaloye, C. A. Wyss, S. P. Fleischmann, O. Gaemperli, et al. Caffeine Decreases Exercise-Induced Myocardial Flow Reserve J. Am. Coll. Cardiol., January 17, 2006; 47(2): 405 - 410. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. A. Kaufmann, M. Namdar, F. Matthew, M. Roffi, S. V. Aschkenasy, B. van der Loo, G. Sutsch, T. F. Luscher, and R. Jenni Novel Doppler Assessment of Intracoronary Volumetric Flow Reserve: Validation Against PET in Patients With or Without Flow-Dependent Vasodilation J. Nucl. Med., August 1, 2005; 46(8): 1272 - 1277. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Y. Wong, W. Rosamond, P. P. Chang, D. J. Couper, A. R. Sharrett, L. D. Hubbard, A. R. Folsom, and R. Klein Retinopathy and Risk of Congestive Heart Failure JAMA, January 5, 2005; 293(1): 63 - 69. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. A. Kaufmann and P. G. Camici Myocardial Blood Flow Measurement by PET: Technical Aspects and Clinical Applications J. Nucl. Med., January 1, 2005; 46(1): 75 - 88. [Full Text] [PDF]
|
|
|
|
|
|
P. A. Kaufmann, O. Rimoldi, T. Gnecchi-Ruscone, R. S. Bonser, T. F. Luscher, and P. G. Camici Systemic Inhibition of Nitric Oxide Synthase Unmasks Neural Constraint of Maximal Myocardial Blood Flow in Humans Circulation, September 14, 2004; 110(11): 1431 - 1436. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Jorg-Ciopor, M. Namdar, J. Turina, R. Jenni, J. Schwitter, M. Turina, O. M. Hess, and P. A. Kaufmann Regional myocardial ischemia in hypertrophic cardiomyopathy: Impact of myectomy J. Thorac. Cardiovasc. Surg., August 1, 2004; 128(2): 163 - 169. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. A. Wyss, P. Koepfli, G. Fretz, M. Seebauer, C. Schirlo, and P. A. Kaufmann Influence of Altitude Exposure on Coronary Flow Reserve Circulation, September 9, 2003; 108(10): 1202 - 1207. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. A. Wyss, P. Koepfli, K. Mikolajczyk, C. Burger, G. K. von Schulthess, and P. A. Kaufmann Bicycle Exercise Stress in PET for Assessment of Coronary Flow Reserve: Repeatability and Comparison with Adenosine Stress J. Nucl. Med., February 1, 2003; 44(2): 146 - 154. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Maas, E. Schwedhelm, J. Albsmeier, and R. H Boger The pathophysiology of erectile dysfunction related to endothelial dysfunction and mediators of vascular function Vascular Medicine, August 1, 2002; 7(3): 213 - 225. [Abstract] [PDF]
|
|
| HOME | SUBSCRIPTIONS | CURRENT ISSUE | PAST ISSUES | CARDIOSOURCE | SEARCH | HELP | FEEDBACK |
