CLINICAL STUDIES
Predictive value of C-reactive protein and troponin T in patients with unstable angina: a comparative analysis
Christopher Heeschen, MD*,
Christian W. Hamm, MD, FACC ,
Jens Bruemmer, MD ,
Maarten L. Simoons, MD, FACC for the CAPTURE Investigators
* Stanford University Medical School, Department of Cardiovascular Medicine, Stanford, California, USA
Kerckhoff-Clinic, Department of Cardiology, Bad Nauheim, Germany
University Hospital Hamburg, Department of Clinical Chemistry, Hamburg, Germany
Erasmus University Rotterdam, Thoraxcenter, Rotterdam, the Netherlands
Manuscript received June 28, 1999;
revised manuscript received December 7, 1999,
accepted January 20, 2000.
Reprint requests and correspondence: Dr. Christopher Heeschen, Stanford University School of Medicine, Department of Cardiovascular Medicine, 300 Pasteur Drive, Stanford, California 94305-5406
heeschen{at}stanford.edu
OBJECTIVES
We evaluated C-reactive protein (CRP) and troponin T (TnT) for predicting six-month cardiac risk in patients with unstable angina.
BACKGROUND
Troponin T is predictive of cardiac risk in patients with unstable angina. The clinical implications of elevated CRP in such patients remains controversial.
METHODS
Baseline TnT and CRP values were determined in 447 patients with unstable angina enrolled in the placebo group of the Chimeric c7E3 AntiPlatelet Therapy in Unstable angina REfractory to standard treatment trial (CAPTURE) trial. All patients underwent a coronary intervention and were followed for a six month period in which 13 deaths and 47 myocardial infarctions were documented (MIs).
RESULTS
Troponin T was >0.1 µg/liter in 30% and CRP was >10 mg/L in 41% of the patients. For the initial 72-h period (including coronary intervention), TnT (17.4% vs. 4.2%; p < 0.001) but not CRP (10.3% vs. 8%; p = 0.41) was predictive of mortality and MI. The TnT-positive patients displayed more frequent recurrent instability before the planned intervention (44.8% vs. 16.9%; p < 0.001), but in the CRP-positive patients, no such increase was observed (25.9% vs. 24.8%; p = 0.92). In contrast, for the six month follow-up period, CRP was predictive of cardiac risk (mortality, MI) (18.9% vs. 9.5%; p = 0.003). Using multivariate analysis, both CRP and TnT emerged as independent predictors of mortality and MI at six- month follow-up. Furthermore, the incidence of coronary restenosis during six-month follow-up was not related to TnT status (3% vs. 4.5%; p = 0.49); however, it was significantly related to CRP status (7% vs. 2.3%; p = 0.03).
CONCLUSIONS
Troponin T, but not CRP, was predictive of cardiac risk during the initial 72-h period, whereas CRP was an independent predictor of both cardiac risk and repeated coronary revascularization (coronary artery bypass graft surgery and percutaneous transluminal coronary angioplasty) during six month follow-up.
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Abbreviations and Acronyms
| | CABG | = coronary artery bypass graft surgery | | CAPTURE | = Chimeric c7E3 AntiPlatelet Therapy in Unstable angina REfractory to standard treatment trial | | CI | = confidence interval | | CK | = creatine kinase | | CRP | = C-reactive protein | | FRISC | = FRagmin during InStability in Coronary artery disease trial | | MI | = myocardial infarction | | OR | = odds ratio | | PTCA | = percutaneous transluminal coronary angioplasty | | TnT | = troponin T |
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|
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|
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28(13):
1598 - 1660.
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[PDF]
|
|
|
|
|
|
|
S. Ryan, G. M Nolan, E. Hannigan, S. Cunningham, C. Taylor, and W. T McNicholas
Cardiovascular risk markers in obstructive sleep apnoea syndrome and correlation with obesity
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62(6):
509 - 514.
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|
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|
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|
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May 1, 2007;
53(5):
882 - 889.
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|
|
|
|
|
|
|
NACB WRITING GROUP MEMBERS, D. A. Morrow, C. P. Cannon, R. L. Jesse, L. K. Newby, J. Ravkilde, A. B. Storrow, A. H.B. Wu, and R. H. Christenson
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Circulation,
April 3, 2007;
115(13):
e356 - e375.
[Full Text]
[PDF]
|
|
|
|
|
|
|
NACB WRITING GROUP MEMBERS, D. A. Morrow, C. P. Cannon, R. L. Jesse, L. K. Newby, J. Ravkilde, A. B. Storrow, A. H.B. Wu, R. H. Christenson, NACB COMMITTEE MEMBERS, et al.
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Clin. Chem.,
April 1, 2007;
53(4):
552 - 574.
[Full Text]
[PDF]
|
|
|
|
|
|
|
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27(24):
2989 - 2995.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E K Iliodromitis, S Kyrzopoulos, I A Paraskevaidis, K G Kolocassides, S Adamopoulos, G Karavolias, and D T Kremastinos
Increased C reactive protein and cardiac enzyme levels after coronary stent implantation. Is there protection by remote ischaemic preconditioning?
Heart,
December 1, 2006;
92(12):
1821 - 1826.
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[PDF]
|
|
|
|
|
|
|
C. M. Westerhout, Y. Fu, M. S. Lauer, S. James, P. W. Armstrong, E. Al-Hattab, R. M. Califf, M. L. Simoons, L. Wallentin, E. Boersma, et al.
Short- and Long-Term Risk Stratification in Acute Coronary Syndromes: The Added Value of Quantitative ST-Segment Depression and Multiple Biomarkers
J. Am. Coll. Cardiol.,
September 5, 2006;
48(5):
939 - 947.
[Abstract]
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[PDF]
|
|
|
|
|
|
|
R L Kennedy and R F Harrison
Identification of patients with evolving coronary syndromes by using statistical models with data from the time of presentation
Heart,
February 1, 2006;
92(2):
183 - 189.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S G Baidya and Q-T Zeng
Helper T cells and atherosclerosis: the cytokine web
Postgrad. Med. J.,
December 1, 2005;
81(962):
746 - 752.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. G. Lakoski, M. Cushman, W. Palmas, R. Blumenthal, R. B. D'Agostino Jr, and D. M. Herrington
The Relationship Between Blood Pressure and C-Reactive Protein in the Multi-Ethnic Study of Atherosclerosis (MESA)
J. Am. Coll. Cardiol.,
November 15, 2005;
46(10):
1869 - 1874.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Saleh, B. Svane, L.-O. Hansson, J. Jensen, T. Nilsson, O. Danielsson, and P. Tornvall
Response of Serum C-Reactive Protein to Percutaneous Coronary Intervention Has Prognostic Value
Clin. Chem.,
November 1, 2005;
51(11):
2124 - 2130.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. De Servi, M. Mariani, G. Mariani, and A. Mazzone
C-Reactive Protein Increase in Unstable Coronary Disease: Cause or Effect?
J. Am. Coll. Cardiol.,
October 18, 2005;
46(8):
1496 - 1502.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Z. Mallat, Ph. G. Steg, J. Benessiano, M.-L. Tanguy, K. A. Fox, J.-P. Collet, O. H. Dabbous, P. Henry, K. F. Carruthers, A. Dauphin, et al.
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J. Am. Coll. Cardiol.,
October 4, 2005;
46(7):
1249 - 1257.
[Abstract]
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[PDF]
|
|
|
|
|
|
|
C. Heeschen
Biomarkers in acute coronary syndromes and their role in diabetic patients
Diabetes and Vascular Disease Research,
October 1, 2005;
2(3):
122 - 127.
[Abstract]
[PDF]
|
|
|
|
|
|
|
L M Biasucci, G Giubilato, F Graziani, and M Piro
CRP is or is not a reliable marker of ischaemic heart disease?
Lupus,
September 1, 2005;
14(9):
752 - 755.
[Abstract]
[PDF]
|
|
|
|
|
|
|
B Lagerqvist, E Diderholm, B Lindahl, S Husted, F Kontny, E Stahle, E Swahn, P Venge, A Siegbahn, and L Wallentin
FRISC score for selection of patients for an early invasive treatment strategy in unstable coronary artery disease
Heart,
August 1, 2005;
91(8):
1047 - 1052.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Tanaka, K. Shimada, T. Sano, M. Namba, T. Sakamoto, Y. Nishida, T. Kawarabayashi, D. Fukuda, and J. Yoshikawa
Multiple Plaque Rupture and C-Reactive Protein in Acute Myocardial Infarction
J. Am. Coll. Cardiol.,
May 17, 2005;
45(10):
1594 - 1599.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G A Large
Contemporary management of acute coronary syndrome
Postgrad. Med. J.,
April 1, 2005;
81(954):
217 - 222.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Heeschen, S. Dimmeler, C. W. Hamm, S. Fichtlscherer, M. L. Simoons, A. M. Zeiher, and CAPTURE Study Investigators
Pregnancy-associated plasma protein-A levels in patients with acute coronary syndromes: Comparison with markers of systemic inflammation, platelet activation, and myocardial necrosis
J. Am. Coll. Cardiol.,
January 18, 2005;
45(2):
229 - 237.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. M. Biasucci
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Circulation,
December 21, 2004;
110(25):
e560 - e567.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. A. Morrow
Preprocedural C-Reactive Protein for Risk Prediction Before Percutaneous Coronary Intervention (PCI): A US Perspective
Clin. Chem.,
September 1, 2004;
50(9):
1489 - 1491.
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Panteghini
Role and importance of biochemical markers in clinical cardiology
Eur. Heart J.,
July 2, 2004;
25(14):
1187 - 1196.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. F Viles-Gonzalez, V. Fuster, and J. J Badimon
Atherothrombosis: A widespread disease with unpredictable and life-threatening consequences
Eur. Heart J.,
July 2, 2004;
25(14):
1197 - 1207.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Segev, S. Kassam, C. E Buller, H. K Lau, J. D Sparkes, P. W Connelly, P. H Seidelin, M. K Natarajan, E. A Cohen, and B. H Strauss
Pre-procedural plasma levels of C-reactive protein and interleukin-6 do not predict late coronary angiographic restenosis after elective stenting
Eur. Heart J.,
June 2, 2004;
25(12):
1029 - 1035.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Monakier, M. Mates, M. W. Klutstein, J. A. Balkin, B. Rudensky, D. Meerkin, and D. Tzivoni
Rofecoxib, a COX-2 Inhibitor, Lowers C-Reactive Protein and Interleukin-6 Levels in Patients With Acute Coronary Syndromes
Chest,
May 1, 2004;
125(5):
1610 - 1615.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P L Sanchez, J L Morinigo, P Pabon, F Martin, I Piedra, I F Palacios, and C Martin-Luengo
Prognostic relations between inflammatory markers and mortality in diabetic patients with non-ST elevation acute coronary syndrome
Heart,
March 1, 2004;
90(3):
264 - 269.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Elsaesser and C. W. Hamm
Acute Coronary Syndrome: The Risk of Being Female
Circulation,
February 10, 2004;
109(5):
565 - 567.
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Heeschen, S. Dimmeler, S. Fichtlscherer, C. W. Hamm, J. Berger, M. L. Simoons, and A. M. Zeiher
Prognostic Value of Placental Growth Factor in Patients With Acute Chest Pain
JAMA,
January 28, 2004;
291(4):
435 - 441.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G.M. Hirschfield and M.B. Pepys
C-reactive protein and cardiovascular disease: new insights from an old molecule
QJM,
November 1, 2003;
96(11):
793 - 807.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. J. Blake and P. M. Ridker
C-reactive protein: a surrogate risk marker or mediator of atherothrombosis?
Am J Physiol Regulatory Integrative Comp Physiol,
November 1, 2003;
285(5):
R1250 - R1252.
[Full Text]
[PDF]
|
|
|
|
|
|
|
S Kennon, A D Timmis, R Whitbourn, and C Knight
C reactive protein for risk stratification in acute coronary syndromes? Verdict: unproven
Heart,
November 1, 2003;
89(11):
1288 - 1290.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. B. Granger, R. J. Goldberg, O. Dabbous, K. S. Pieper, K. A. Eagle, C. P. Cannon, F. Van de Werf, A. Avezum, S. G. Goodman, M. D. Flather, et al.
Predictors of Hospital Mortality in the Global Registry of Acute Coronary Events
Arch Intern Med,
October 27, 2003;
163(19):
2345 - 2353.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. J. Kereiakes
Adjunctive Pharmacotherapy before Percutaneous Coronary Intervention in Non-ST-Elevation Acute Coronary Syndromes: The Role of Modulating Inflammation
Circulation,
October 21, 2003;
108(90161):
III-22 - 27.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Baldus, C. Heeschen, T. Meinertz, A. M. Zeiher, J. P. Eiserich, T. Munzel, M. L. Simoons, C. W. Hamm, and on behalf of the CAPTURE Investigators
Myeloperoxidase Serum Levels Predict Risk in Patients With Acute Coronary Syndromes
Circulation,
September 23, 2003;
108(12):
1440 - 1445.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. G. Hackam and S. S. Anand
Emerging Risk Factors for Atherosclerotic Vascular Disease: A Critical Review of the Evidence
JAMA,
August 20, 2003;
290(7):
932 - 940.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Sano, A. Tanaka, M. Namba, Y. Nishibori, Y. Nishida, T. Kawarabayashi, D. Fukuda, K. Shimada, and J. Yoshikawa
C-Reactive Protein and Lesion Morphology in Patients With Acute Myocardial Infarction
Circulation,
July 22, 2003;
108(3):
282 - 285.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. Koenig
C-reactive protein and cardiovascular risk: an update on what is going on in cardiology
Nephrol. Dial. Transplant.,
June 1, 2003;
18(6):
1039 - 1041.
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. M. A. Lobo, F. R. M. Lobo, D. P. Bota, F. Lopes-Ferreira, H. M. Soliman, C. Melot, and J.-L. Vincent
C-Reactive Protein Levels Correlate With Mortality and Organ Failure in Critically Ill Patients
Chest,
June 1, 2003;
123(6):
2043 - 2049.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Heeschen, S. Dimmeler, C. W. Hamm, S. Fichtlscherer, E. Boersma, M. L. Simoons, A. M. Zeiher, and for the CAPTURE Study Investigators
Serum Level of the Antiinflammatory Cytokine Interleukin-10 Is an Important Prognostic Determinant in Patients With Acute Coronary Syndromes
Circulation,
April 29, 2003;
107(16):
2109 - 2114.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. G. L. Biondi-Zoccai, A. Abbate, G. Liuzzo, and L. M. Biasucci
Atherothrombosis, inflammation, and diabetes
J. Am. Coll. Cardiol.,
April 2, 2003;
41(7):
1071 - 1077.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. K. James, P. Armstrong, E. Barnathan, R. Califf, B. Lindahl, A. Siegbahn, M. L. Simoons, E. J. Topol, P. Venge, L. Wallentin, et al.
Troponin and C-reactive protein have different relations to subsequent mortality and myocardial infarction after acute coronary syndrome: A GUSTO-IV substudy
J. Am. Coll. Cardiol.,
March 19, 2003;
41(6):
916 - 924.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. J. Blake and P. M. Ridker
C-reactive protein and other inflammatory risk markers in acute coronary syndromes
J. Am. Coll. Cardiol.,
February 19, 2003;
41(4_Suppl_S):
37S - 42S.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Kaul, L. K. Newby, Y. Fu, V. Hasselblad, K. W. Mahaffey, R. H. Christenson, R. A. Harrington, E. M. Ohman, E. J. Topol, R. M. Califf, et al.
Troponin T and quantitative ST-segment depression offer complementary prognostic information in the risk stratification of acute coronary syndrome patients
J. Am. Coll. Cardiol.,
February 5, 2003;
41(3):
371 - 380.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Heeschen, S. Dimmeler, C. W. Hamm, E. Boersma, A. M. Zeiher, M. L. Simoons, and on Behalf of the CAPTURE (c7E3 Anti-Platelet Thera
Prognostic Significance of Angiogenic Growth Factor Serum Levels in Patients With Acute Coronary Syndromes
Circulation,
February 4, 2003;
107(4):
524 - 530.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
The ENCORE Investigators*
Effect of Nifedipine and Cerivastatin on Coronary Endothelial Function in Patients With Coronary Artery Disease: The ENCORE I Study (Evaluation of Nifedipine and Cerivastatin On Recovery of coronary Endothelial function)
Circulation,
January 28, 2003;
107(3):
422 - 428.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T Lenderink, E Boersma, C Heeschen, A Vahanian, M.-J de Boer, V Umans, M.J.B.M van den Brand, C.W Hamm, M.L Simoons, and for the CAPTURE investigators
Elevated troponin T and C-reactive protein predict impaired outcome for 4 years in patients with refractory unstable angina, and troponin T predicts benefit of treatment with abciximab in combination with PTCA
Eur. Heart J.,
January 1, 2003;
24(1):
77 - 85.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J Oldgren, L Wallentin, L Grip, R Linder, B.L Norgaard, and A Siegbahn
Myocardial damage, inflammation and thrombin inhibition in unstable coronary artery disease
Eur. Heart J.,
January 1, 2003;
24(1):
86 - 93.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Lowbeer, A. Gutierrez, S. A. Gustafsson, R. Norrman, J. Hulting, and A. Seeberger
Elevated cardiac troponin T in peritoneal dialysis patients is associated with CRP and predicts all-cause mortality and cardiac death
Nephrol. Dial. Transplant.,
December 1, 2002;
17(12):
2178 - 2183.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. S. Sabatine, D. A. Morrow, C. P. Cannon, S. A. Murphy, L. A. Demopoulos, P. M. DiBattiste, C. H. McCabe, E. Braunwald, and C. M. Gibson
Relationship between baseline white blood cell count and degree of coronary artery disease and mortality in patients with acute coronary syndromes: A TACTICS-TIMI 18 substudy
J. Am. Coll. Cardiol.,
November 20, 2002;
40(10):
1761 - 1768.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. N. Zairis, J. A. Ambrose, S. J. Manousakis, A. S. Stefanidis, O. A. Papadaki, H. I. Bilianou, M. C. DeVoe, C. N. Fakiolas, E. G. Pissimissis, C. D. Olympios, et al.
The impact of plasma levels of C-reactive protein, lipoprotein (a) and homocysteine on the long-term prognosis after successful coronary stenting: The global evaluation of new events and restenosis after stent implantation study
J. Am. Coll. Cardiol.,
October 16, 2002;
40(8):
1375 - 1382.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. L. Bhatt and E. J. Topol
Need to Test the Arterial Inflammation Hypothesis
Circulation,
July 2, 2002;
106(1):
136 - 140.
[Full Text]
[PDF]
|
|
|
|
|
|
|
E.R. Ferreiros, R. Kevorkian, J.J. Fuselli, J. Guetta, C.P. Boissonnet, D. di Toro, R. Cragnolino, O. Masoli, A. Cagide, and J. Krauss
First national survey on management strategies in non ST-elevation acute ischaemic syndromes in Argentina. Results of the STRATEG-SIA study
Eur. Heart J.,
July 1, 2002;
23(13):
1021 - 1029.
[Abstract]
[Full Text]
[PDF]
|
|
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|
|
|
|
E. Ronner, E. Boersma, G.-J. Laarman, G. A. Somsen, R. A. Harrington, J. W. Deckers, E. J. Topol, R. M. Califf, and M. L. Simoons
Early angioplasty in acute coronary syndromes without persistent st-segment elevation improves outcome but increases the need for six-month repeat revascularization: An analysis of the pursuit trial
J. Am. Coll. Cardiol.,
June 19, 2002;
39(12):
1924 - 1929.
[Abstract]
[Full Text]
[PDF]
|
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|
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|
|
G.J. Blake and P.M. Ridker
C-reactive protein and prognosis after percutaneous coronary intervention
Eur. Heart J.,
June 2, 2002;
23(12):
923 - 925.
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Mueller, H. J. Buettner, J. M. Hodgson, S. Marsch, A. P. Perruchoud, H. Roskamm, and F.-J. Neumann
Inflammation and Long-Term Mortality After Non-ST Elevation Acute Coronary Syndrome Treated With a Very Early Invasive Strategy in 1042 Consecutive Patients
Circulation,
March 26, 2002;
105(12):
1412 - 1415.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Libby, P. M. Ridker, and A. Maseri
Inflammation and Atherosclerosis
Circulation,
March 5, 2002;
105(9):
1135 - 1143.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Maseri and D. Cianflone
Inflammation in acute coronary syndromes
Eur. Heart J. Suppl.,
March 1, 2002;
4(suppl_B):
B8 - B13.
[Abstract]
[PDF]
|
|
|
|
|
|
|
J. S. Zebrack, J. B. Muhlestein, B. D. Horne, J. L. Anderson, and Intermountain Heart Collaboration Study Group
C-reactive protein and angiographic coronary artery disease: independent and additive predictors of risk in subjects with angina
J. Am. Coll. Cardiol.,
February 20, 2002;
39(4):
632 - 637.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. D. White and C. K. Wong
Risk stratification and treatment benefits in patients with non-ST-elevation acute coronary syndromes
Eur. Heart J.,
February 1, 2002;
23(3):
187 - 191.
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. H. Walter, S. Fichtlscherer, M. B. Britten, P. Rosin, W. Auch-Schwelk, V. Schachinger, and A. M. Zeiher
Statin therapy, inflammation and recurrent coronary events in patients following coronary stent implantation
J. Am. Coll. Cardiol.,
December 1, 2001;
38(7):
2006 - 2012.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. V. Zalai, M. D. Kolodziejczyk, L. Pilarski, A. Christov, P. N. Nation, M. Lundstrom-Hobman, W. Tymchak, V. Dzavik, D. P. Humen, W. J. Kostuk, et al.
Increased circulating monocyte activation in patients with unstable coronary syndromes
J. Am. Coll. Cardiol.,
November 1, 2001;
38(5):
1340 - 1347.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. J. Blake and P. M. Ridker
Novel Clinical Markers of Vascular Wall Inflammation
Circ. Res.,
October 26, 2001;
89(9):
763 - 771.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. P. Chew, D. L. Bhatt, M. A. Robbins, M. S. Penn, J. P. Schneider, M. S. Lauer, E. J. Topol, and S. G. Ellis
Incremental Prognostic Value of Elevated Baseline C-Reactive Protein Among Established Markers of Risk in Percutaneous Coronary Intervention
Circulation,
August 28, 2001;
104(9):
992 - 997.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. C. Smith Jr, J. T. Dove, A. K. Jacobs, J. Ward Kennedy, D. Kereiakes, M. J. Kern, R. E. Kuntz, J. J. Popma, H. V. Schaff, D. O. Williams, et al.
ACC/AHA guidelines for percutaneous coronary intervention (revision of the 1993 PTCA guidelines): A report of the American College of Cardiology/ American Heart Association Task Force on practice guidelines (Committee to revise the 1993 guidelines for percutaneous transluminal coronary angioplasty) endorsed by the Society for Cardiac Angiography and Interventions
J. Am. Coll. Cardiol.,
June 15, 2001;
37(8):
2239 - 2239.
[Full Text]
[PDF]
|
|
|
|
|
|
|
N T Mulvihill, J B Foley, R T Murphy, R Curtin, P A Crean, and M Walsh
Risk stratification in unstable angina and non-Q wave myocardial infarction using soluble cell adhesion molecules
Heart,
June 1, 2001;
85(6):
623 - 627.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
C.W. Hamm
GP IIb/IIIa receptor antagonists in unstable angina: troponin level-based patient selection
Eur. Heart J. Suppl.,
May 1, 2001;
3(suppl_A):
A14 - A20.
[Abstract]
[PDF]
|
|
|
|
|
|
|
Predictive Value of C-Reactive Protein and Troponin T in Unstable Angina
Journal Watch Emergency Medicine,
July 1, 2000;
2000(701):
5 - 5.
[Full Text]
|
|
|
|
|
|
|
Troponin T and C-Reactive Protein Are Complementary Risk Predictors
Journal Watch (General),
May 23, 2000;
2000(523):
4 - 4.
[Full Text]
|
|
|
|
|
|
|
C. Heeschen, C. W. Hamm, U. Laufs, S. Snapinn, M. Bohm, and H. D. White
Withdrawal of Statins Increases Event Rates in Patients With Acute Coronary Syndromes
Circulation,
March 26, 2002;
105(12):
1446 - 1452.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. P. Burke, R. P. Tracy, F. Kolodgie, G. T. Malcom, A. Zieske, R. Kutys, J. Pestaner, J. Smialek, and R. Virmani
Elevated C-Reactive Protein Values and Atherosclerosis in Sudden Coronary Death: Association With Different Pathologies
Circulation,
April 30, 2002;
105(17):
2019 - 2023.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
