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J Am Coll Cardiol, 2000; 35:477-484
© 2000 by the American College of Cardiology Foundation
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CLINICAL STUDIES

Importance of imaging method over imaging modality in noninvasive determination of left ventricular volumes and ejection fraction

Assessment by two- and three-dimensional echocardiography and magnetic resonance imaging

Michael L. Chuang, MS*, Mark G. Hibberd, MD, PhD*, Carol J. Salton, BA*, Raymond A. Beaudin, MS{dagger}, Marilyn F. Riley, BS*, Robert A. Parker, ScD{ddagger}, Pamela S. Douglas, MD, FACC* and Warren J. Manning, MD, FACC* §

* Charles A. Dana Research Institute and the Harvard-Thorndike Laboratory of the Department of Medicine, Cardiovascular Division, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
{dagger} Hewlett Packard Company, Andover, Massachusetts, USA
{ddagger} Biometrics Center, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
§ Department of Radiology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA

Manuscript received January 8, 1999; revised manuscript received September 10, 1999, accepted October 21, 1999.

Reprint requests and correspondence: Dr. Warren J. Manning, Cardiovascular Division, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, Massachusetts 02215
wmanning{at}caregroup.harvard.edu

OBJECTIVES

This study sought to determine the concordance between biplane and volumetric echocardiography and magnetic resonance imaging (MRI) strategies and their impact on the classification of patients according to left ventricular (LV) ejection fraction (EF) (LVEF).

BACKGROUND

Transthoracic echocardiography and MRI are noninvasive imaging modalities well suited for serial evaluation of LV volume and LVEF. Despite the accuracy and reproducibility of volumetric methods, quantitative biplane methods are commonly used, as they minimize both scanning and analysis times.

METHODS

Thirty-five adult subjects, including 25 patients with dilated cardiomyopathies, were evaluated by biplane and volumetric (cardiac short-axis stack) cine MRI and by biplane and volumetric (three-dimensional) transthoracic echocardiography. Left ventricular volume, LVEF and LV function categories (LVEF ≥55%, >35% to <55% and ≤35%) were then determined.

RESULTS

Biplane echocardiography underestimated LV volume with respect to the other three strategies (p < 0.01). There were no significant differences (p > 0.05) between any of the strategies for quantitative LVEF. Volumetric MRI and volumetric echocardiography differed by a single functional category for 2 patients (8%). Six to 11 patients (24% to 44%) differed when comparing biplane and volumetric methods. Ten patients (40%) changed their functional status when biplane MRI and biplane echocardiography were compared; this comparison also revealed the greatest mean absolute difference in estimates of EF for those subjects whose EF functional category had changed.

CONCLUSIONS

Volumetric MRI and volumetric echocardiographic measures of LV volume and LVEF agree well and give similar results when used to stratify patients with dilated cardiomyopathy according to systolic function. Agreement is poor between biplane and volumetric methods and worse between biplane methods, which assigned 40% of patients to different categories according to LVEF. The choice of imaging method (volumetric or biplane) has a greater impact on the results than does the choice of imaging modality (echocardiography or MRI) when measuring LV volume and systolic function.

Abbreviations and Acronyms
  2D = two-dimensional
  3D = three-dimensional
  ED = end-diastolic
  EDV = end-diastolic volume
  EF = ejection fraction
  ES = end-systolic
  ESV = end-systolic volume
  LV = left ventricle or ventricular
  LVEF = left ventricular ejection fraction
  MRI = magnetic resonance imaging




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