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CLINICAL STUDIES

Persistent ST segment depression in precordial leads V5–V6 after Q-wave anterior wall myocardial infarction is associated with restrictive physiology of the left ventricle

^a Department of Cardiology, Rabin Medical Center, Beilinson Campus, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

Manuscript received December 9, 1998; revised manuscript received September 10, 1999, accepted October 27, 1999.

Reprint requests and correspondence: Dr. David Hasdai, Department of Cardiology, Rabin Medical Center (Beilinson Campus), Petah Tiqva, 49100, Israel
dhasdai{at}post.tau.ac.il

OBJECTIVES

To examine the relationship between the persistence of ST segment depression in leads V5–V6 after Q-wave anterior wall myocardial infarction (MI) and the filling pattern of the left ventricle (LV).

BACKGROUND

Precordial ST segment depression predominantly in leads V5–V6 is associated with increased in-hospital morbidity and mortality after acute myocardial ischemia, perhaps due to reduced diastolic distensibility of the LV.

METHODS

We prospectively studied 19 patients after Q-wave anterior wall MI (>6 months). All patients underwent 12-lead ECG recording, symptom-limited treadmill exercise testing with single photon emission computed tomography thallium-201 imaging, transthoracic Doppler echocardiography, cardiac catheterization and measurement of circulating atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) levels. Patients were classified based on the presence of ST segment depression in leads V5–V6: Group I = ST segment depression <0.1 mV (n = 10); Group II = ST segment depression 0.1 mV (n = 9).

RESULTS

Patients in Group II had greater LV end diastolic pressures (32.4 ± 6.5 mm Hg vs. 14.8 ± 6.1 mm Hg; p = 0.0001), higher plasma ANP (44.4 ± 47.1 pg/ml vs. 10.7 ± 14 pg/ml; p = 0.04) and BNP levels (89.4 ± 62.7 pg/ml vs. 23.6 ± 33.1 pg/ml; p = 0.01), greater left atrium area (20.6 ± 3.1 cm² vs. 17.8 ± 2.4 cm²; p = 0.05), lower peak atrial (A), higher early (E) mitral inflow velocities, a higher E/A ratio and a lower deceleration time (167 ± 44 ms vs. 220 ± 40 ms; p = 0.05). Lung thallium uptake during exercise was more common in Group II (78% vs. 10%, p = 0.04).

CONCLUSIONS

Persistent ST segment depression in leads V5–V6 in survivors of Q-wave anterior wall MI is associated with increased LV filling pressure and a restrictive LV filling pattern.

Abbreviations and Acronyms   A = peak atrial velocity   ACE = angiotensin converting enzyme   AMI = acute myocardial infarction   ANP = atrial natriuretic peptide   BNP = brain natriuretic peptide   DT = decceleration time   E = peak inflow early velocity   E/A = ratio of E and A   FS = fractional shortening   LV = left ventricle or ventricular   LVEDP = left ventricular end diastolic pressure   LVEF = left ventricular ejection fraction   MI = myocardial infarction   SPECT = single photon emission computed tomography

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