JACC
HOME SUBSCRIPTIONS CURRENT ISSUE PAST ISSUES CARDIOSOURCE SEARCH HELP FEEDBACK
 QUICK SEARCH:   [advanced]


     


J Am Coll Cardiol, 2000; 35:277-283
© 2000 by the American College of Cardiology Foundation
This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Neunteufl, T.
Right arrow Articles by Kostner, K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Neunteufl, T.
Right arrow Articles by Kostner, K.

CLINICAL STUDIES

Effects of vitamin E on chronic and acute endothelial dysfunction in smokers

Thomas Neunteufl, MDa, Ute Priglinger, MDa, Sandra Heher, MDa, Manfred Zehetgruber, MDa, Gabor Söregi, MD*, Stephan Lehr{dagger}, Kurt Huber, MDa, Gerald Maurer, MD, FACCa, Franz Weidinger, MD{ddagger} and Karam Kostner, MDa

a Department of Cardiology, University of Vienna, Vienna, Austria
* Department of Clinical Chemistry, University of Vienna, Vienna, Austria
{dagger} Institute for Medical Statistics, University of Vienna, Vienna, Austria
{ddagger} Department of Cardiology, University of Innsbruck, Innsbruck, Austria

Manuscript received February 2, 1999; revised manuscript received August 16, 1999, accepted October 18, 1999.

Reprint requests and correspondence: Dr. Thomas Neunteufl, Department of Cardiology, University of Vienna Medical School, Währinger Gürtel 18-20, A-1090 Vienna, Austria
TNEUNTEUFL{at}pop3.kard.akh-wien.ac.at

OBJECTIVES

The aims of this study were to determine whether chronic or acute impairment of flow mediated vasodilation (FMD) in the brachial artery of smokers can be restored or preserved by the antioxidant vitamin E.

BACKGROUND

Transient impairment of endothelial function after heavy cigarette smoking and chronic endothelial dysfunction in smokers result at least in part from increased oxidative stress.

METHODS

We studied 22 healthy male smokers (mean ± SD, 23 ± 9 cigarettes per day) randomly assigned to receive either 600 IU vitamin E per day (n = 11, age 28 ± 6 years) or placebo (n = 11, age 27 ± 6 years) for four weeks and 11 age-matched healthy male nonsmokers. Flow mediated vasodilation and endothelium-independent, nitroglycerin-induced dilation were assessed in the brachial artery using high resolution ultrasound (7.5 MHz) at baseline and after therapy. Subjects stopped smoking 2 h before the ultrasound examinations. At the end of the treatment period, a third scan was obtained 20 min after smoking a cigarette (0.6 mg nicotine, 7 mg tare) to estimate transient impairment of FMD.

RESULTS

Flow mediated vasodilation at baseline was abnormal in the vitamin E (5.3 ± 3.8, p < 0.01) and in the placebo group (6.4 ± 3.5, p < 0.05) compared with nonsmoking controls (11.6 ± 4.7). Using a two-way repeated measures analysis of variance (ANOVA) to examine the effects of vitamin E on FMD, we found no effect for the grouping factor (p = 0.5834) in the ANOVA over time but a highly significant difference with respect to time (p = 0.0065). The interaction of the time factor and the grouping factor also proved to be significant (p = 0.0318). Flow mediated vasodilation values remained similar after treatment for four weeks in both groups but declined faster after smoking a cigarette in subjects taking placebo compared with those receiving vitamin E (p values from successive differences for the time/group factor: 0.0001/0.0017). The transient attenuation of FMD (calculated as the percent change in FMD) was related to the improvement of the antioxidant status, estimated as percent changes in thiobarbituric acid-reactive substances (r = –0.67, p = 0.0024). Nitroglycerin-induced dilation did not differ between study groups at baseline or after therapy.

CONCLUSIONS

These results demonstrate that oral supplementation of vitamin E can attenuate transient impairment of endothelial function after heavy smoking due to an improvement of the oxidative status but cannot restore chronic endothelial dysfunction within four weeks in healthy male smokers.

Abbreviations and Acronyms
  ANOVA = analysis of variance
  CAD = coronary artery disease
  FMD = flow-mediated dilation
  LDL-C = low-density lipoprotein cholesterol
  NMD = nitroglycerin-induced dilation
  TBA = thiobarbituric acid
  TBARS = thiobarbituric acid–reactive substances




This article has been cited by other articles:


Home page
Arterioscler. Thromb. Vasc. Bio.Home page
J. A. Beckman
Does Cuff Location for FMD Matter in Smokers?
Arterioscler. Thromb. Vasc. Biol., August 1, 2007; 27(8): e140 - e140.
[Full Text] [PDF]


Home page
J. Am. Coll. Nutr.Home page
K. Karatzi, C. Papamichael, E. Karatzis, T. G. Papaioannou, P. Th. Voidonikola, J. Lekakis, and A. Zampelas
Acute Smoking Induces Endothelial Dysfunction in Healthy Smokers. Is This Reversible by Red Wine's Antioxidant Constituents?
J. Am. Coll. Nutr., February 1, 2007; 26(1): 10 - 15.
[Abstract] [Full Text] [PDF]


Home page
Hum ReprodHome page
E. H. Y. Ng, C. C. W. Chan, O. S. Tang, W. S. B. Yeung, and P. C. Ho
Factors affecting endometrial and subendometrial blood flow measured by three-dimensional power Doppler ultrasound during IVF treatment
Hum. Reprod., April 1, 2006; 21(4): 1062 - 1069.
[Abstract] [Full Text] [PDF]


Home page
ANGIOLOGYHome page
A. Silvestro, V. Schiano, R. Bucur, G. Brevetti, F. Scopacasa, and M. Chiariello
Effect of Propionylcarnitine on Changes in Endothelial Function and Plasma Levels of Adhesion Molecules Induced by Acute Exercise in Patients with Intermittent Claudication
Angiology, March 1, 2006; 57(2): 145 - 154.
[Abstract] [PDF]


Home page
CLIN APPL THROMB HEMOSTHome page
E. Arikan and S. Sen
Endothelial Damage and Hemostatic Markers in Patients with Uncomplicated Mild-to-Moderate Hypertension and Relationship with Risk Factors
Clinical and Applied Thrombosis/Hemostasis, April 1, 2005; 11(2): 147 - 159.
[Abstract] [PDF]


Home page
Eur Heart JHome page
M. L. Bots, J. Westerink, T. J. Rabelink, and E. J.P. de Koning
Assessment of flow-mediated vasodilatation (FMD) of the brachial artery: effects of technical aspects of the FMD measurement on the FMD response
Eur. Heart J., February 2, 2005; 26(4): 363 - 368.
[Abstract] [Full Text] [PDF]


Home page
ANGIOLOGYHome page
B. Takase, H. Etsuda, Y. Matsushima, M. Ayaori, H. Kusano, A. Hamabe, A. Uehata, F. Ohsuzu, M. Ishihara, and A. Kurita
Effect of Chronic Oral Supplementation with Vitamins on the Endothelial Function in Chronic Smokers
Angiology, November 1, 2004; 55(6): 653 - 660.
[Abstract] [PDF]


Home page
ANGIOLOGYHome page
B. Takase, H. Etsuda, Y. Matsushima, M. Ayaori, H. Kusano, A. Hamabe, A. Uehata, F. Ohsuzu, M. Ishihara, and A. Kurita
Effect of Chronic Oral Supplementation with Vitamins on the Endothelial Function in Chronic Smokers
Angiology, November 1, 2004; 55(6): 653 - 660.
[Abstract] [PDF]


Home page
J. Am. Coll. Nutr.Home page
D. L. Katz, M. A. Evans, W. Chan, H. Nawaz, B. P. Comerford, M. L. Hoxley, V. Y. Njike, and P. M. Sarrel
Oats, Antioxidants and Endothelial Function in Overweight, Dyslipidemic Adults
J. Am. Coll. Nutr., October 1, 2004; 23(5): 397 - 403.
[Abstract] [Full Text] [PDF]


Home page
J. Appl. Physiol.Home page
L. Stoner, M. Sabatier, K. Edge, and K. McCully
Relationship between blood velocity and conduit artery diameter and the effects of smoking on vascular responsiveness
J Appl Physiol, June 1, 2004; 96(6): 2139 - 2145.
[Abstract] [Full Text] [PDF]


Home page
Hum ReprodHome page
N.J. Raine-Fenning, B.K. Campbell, N.R. Kendall, J.S. Clewes, and I.R. Johnson
Quantifying the changes in endometrial vascularity throughout the normal menstrual cycle with three-dimensional power Doppler angiography
Hum. Reprod., February 1, 2004; 19(2): 330 - 338.
[Abstract] [Full Text] [PDF]


Home page
Arterioscler. Thromb. Vasc. Bio.Home page
M. Raitakari, T. Ilvonen, M. Ahotupa, T. Lehtimaki, A. Harmoinen, P. Suominen, J. Elo, J. Hartiala, and O. T. Raitakari
Weight Reduction With Very-Low-Caloric Diet and Endothelial Function in Overweight Adults: Role of Plasma Glucose
Arterioscler. Thromb. Vasc. Biol., January 1, 2004; 24(1): 124 - 128.
[Abstract] [Full Text] [PDF]


Home page
Cardiovasc ResHome page
N. Singh, J. Graves, P. D Taylor, R. J MacAllister, and D. R.J Singer
Effects of a 'healthy' diet and of acute and long-term vitamin C on vascular function in healthy older subjects
Cardiovasc Res, October 1, 2002; 56(1): 118 - 125.
[Abstract] [Full Text] [PDF]


Home page
StrokeHome page
S. Kiechl, P. Werner, G. Egger, F. Oberhollenzer, M. Mayr, Q. Xu, W. Poewe, and J. Willeit
Active and Passive Smoking, Chronic Infections, and the Risk of Carotid Atherosclerosis: Prospective Results From the Bruneck Study
Stroke, September 1, 2002; 33(9): 2170 - 2176.
[Abstract] [Full Text] [PDF]


Home page
J Am Coll CardiolHome page
T. Neunteufl, S. Heher, K. Kostner, G. Mitulovic, S. Lehr, G. Khoschsorur, R. W. Schmid, G. Maurer, and T. Stefenelli
Contribution of nicotine to acute endothelial dysfunction in long-term smokers
J. Am. Coll. Cardiol., January 16, 2002; 39(2): 251 - 256.
[Abstract] [Full Text] [PDF]


Home page
J Am Coll CardiolHome page
J. H. Stein, C. M. Carlsson, K. Papcke-Benson, S. E. Aeschlimann, A. Bodemer, M. Carnes, and P. E. McBride
The effects of lipid-lowering and antioxidant vitamin therapies on flow-mediated vasodilation of the brachial artery in older adults with hypercholesterolemia
J. Am. Coll. Cardiol., December 1, 2001; 38(7): 1806 - 1813.
[Abstract] [Full Text] [PDF]


Home page
J Am Coll CardiolHome page
M. Imamura, S. Biro, T. Kihara, S. Yoshifuku, K. Takasaki, Y. Otsuji, S. Minagoe, Y. Toyama, and C. Tei
Repeated thermal therapy improves impaired vascular endothelial function in patients with coronary risk factors
J. Am. Coll. Cardiol., October 1, 2001; 38(4): 1083 - 1088.
[Abstract] [Full Text] [PDF]


Home page
Arterioscler. Thromb. Vasc. Bio.Home page
N. M. de Roos, M. L. Bots, and M. B. Katan
Replacement of Dietary Saturated Fatty Acids by Trans Fatty Acids Lowers Serum HDL Cholesterol and Impairs Endothelial Function in Healthy Men and Women
Arterioscler. Thromb. Vasc. Biol., July 1, 2001; 21(7): 1233 - 1237.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Clin. Nutr.Home page
A. A Brown and F. B Hu
Dietary modulation of endothelial function: implications for cardiovascular disease
Am. J. Clinical Nutrition, April 1, 2001; 73(4): 673 - 686.
[Abstract] [Full Text] [PDF]


Home page
Endocr. Rev.Home page
J. Calles-Escandon and M. Cipolla
Diabetes and Endothelial Dysfunction: A Clinical Perspective
Endocr. Rev., February 1, 2001; 22(1): 36 - 52.
[Abstract] [Full Text]




HOME SUBSCRIPTIONS CURRENT ISSUE PAST ISSUES CARDIOSOURCE SEARCH HELP FEEDBACK
Copyright © 2000 by the American College of Cardiology Foundation.