CLINICAL STUDIES
Light-to-moderate alcohol consumption and mortality in the physicians’ health study enrollment cohort
J. Michael Gaziano, MD*   ||,
Thomas A. Gaziano, MD* ,
Robert J. Glynn, PhD* ¶,
Howard D. Sesso, MPH* #,
Umed A. Ajani, MBBS* ,
Meir J. Stampfer, MD # **,
JoAnn E. Manson, MD* #,
Charles H. Hennekens, MD and
Julie E. Buring, ScD* #
* Division of Preventive Medicine, Department of Medicine, Brigham and Women’s Hospital, Boston, Massachusetts, USA
Cardiovascular Division, Department of Medicine, Brigham and Women’s Hospital, Boston, Massachusetts, USA
Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital, Boston, Massachusetts, USA
Harvard Medical School, Boston, Massachusetts, USA
|| Massachusetts Veterans Epidemiology Research and Information Center, VA Boston Healthcare System, Boston, Massachusetts, USA
¶ Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, USA
# Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
** Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA
Department of Ambulatory Care and Prevention, Harvard Medical School, Boston, Massachusetts, USA. Dr. Hennekens is currently Visiting Professor of Medicine, and Epidemiology and Public Health, University of Miami School of Medicine, Miami, FL. Dr. Hennekens’ current address is 1415 West Camino Real, Boca Raton, Florida 33486
Manuscript received December 17, 1998;
revised manuscript received July 30, 1999,
accepted October 5, 1999.
Reprint requests and correspondence: Dr. J. Michael Gaziano, Brigham and Women’s Hospital, 900 Commonwealth Avenue East, Boston, Massachusetts 02215-1204
gaziano{at}maveric.org
OBJECTIVES
This study examined the relationship between light-to-moderate alcohol consumption and cause-specific mortality.
BACKGROUND
Previous studies suggest a J-shaped relation between alcohol and total mortality in men. A decrease in cardiovascular disease (CVD) mortality without a significant increase in other causes of mortality may explain the overall risk reduction at light-to-moderate levels.
METHODS
We conducted a prospective cohort study of 89,299 U.S. men from the Physicians’ Health Study enrollment cohort who were 40 to 84 years old in 1982 and free of known myocardial infarction, stroke, cancer or liver disease at baseline. Usual alcohol consumption was estimated by a limited food frequency questionnaire.
RESULTS
There were 3,216 deaths over 5.5 years of follow-up. We observed a U-shaped relationship between alcohol consumption and total mortality. Compared with rarely/never drinkers, consumers of 1, 2 to 4 and 5 to 6 drinks per week and 1 drink per day had significant reductions in risk of death (multivariate relative risks [RRs] of 0.74, 0.77, 0.78 and 0.82, respectively) with no overall benefit or harm detected at the  2 drinks per day level (RR = 0.95; 95% confidence interval (CI), 0.79 to 1.14). The relationship with CVD mortality was inverse or L-shaped with apparent risk reductions even in the highest category of 2 drinks per day (RR = 0.76; 95% CI, 0.57 to 1.01). We found no clear harm or benefit for total or common site-specific cancers. For remaining other cancers, there was a nonsignificant 28% increased risk for those consuming 2 drinks per day.
CONCLUSIONS
These data support a U-shaped relation between alcohol and total mortality among light-to-moderate drinking men. The U-shaped curve may reflect an inverse association for CVD mortality, no association for common site-specific cancers and a possible positive association for less common cancers.
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Abbreviations and Acronyms
| | CHD | = coronary heart disease | | CI | = confidence interval | | CVD | = cardiovascular disease | | MI | = myocardial infarction | | RR | = relative risk |
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