JACC
HOME SUBSCRIPTIONS CURRENT ISSUE PAST ISSUES CARDIOSOURCE SEARCH HELP FEEDBACK
QUICK SEARCH:   [advanced]


     

J Am Coll Cardiol, 2000; 35:112-118
© 2000 by the American College of Cardiology Foundation
This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hoffmeister, A.
Right arrow Articles by Koenig, W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hoffmeister, A.
Right arrow Articles by Koenig, W.

CLINICAL STUDIES

Seropositivity to chlamydial lipopolysaccharide and chlamydia pneumoniae, systemic inflammation and stable coronary artery disease

Negative results of a case-control study

Albrecht Hoffmeister, MD*, Dietrich Rothenbacher, MD, MPH{dagger}, Peter Wanner, MS*, Guenter Bode, PhD§, Kenneth Persson, MD, PhD{ddagger}, Hermann Brenner, MD, MPH{dagger}, Vinzenz Hombach, MD* and Wolfgang Koenig, MD, FACC*

* Department of Internal Medicine II–Cardiology, University of Ulm, Ulm, Germany
{dagger} Department of Epidemiology, University of Ulm, Ulm, Germany
{ddagger} Department of Clinical Microbiology, Malmö General Hospital, University of Lund, Malmö, Sweden
§ Department of Internal Medicine I–Gastroenterology, University of Ulm, Ulm, Germany

Manuscript received March 9, 1999; revised manuscript received July 22, 1999, accepted September 21, 1999.

Reprint requests and correspondence: Dr. A. Hoffmeister, Abteilung Innere Medizin II, Medizinische Universitätsklinik, Robert-Koch Str. 8, D-89081 Ulm, Germany.
albrecht.hoffmeister{at}medizin.uni-ulm.de

OBJECTIVES

We investigated the association between seropositivity to chlamydial lipopolysaccharide (cLPS) or Chlamydia pneumoniae (CP) and angiographically documented coronary artery disease (CAD), and we examined the relationship between serostatus and markers of systemic inflammation.

BACKGROUND

The potential contribution of CP to atherogenesis is still a matter of debate, and inflammation has been suggested to represent the link between infection and atherosclerotic disease.

METHODS

Subjects age 40 to 68 years were recruited for this case-control study between October 1996 and November 1997: 312 patients with at least one coronary stenosis >50% and 479 age- and sex-matched blood donors without manifest CAD or history of angina. Antibodies against cLPS and CP, C-reactive protein (CRP), fibrinogen, plasma viscosity, leukocytes and neutrophils were determined. The study had a power of >80% to detect an odds ratio (OR) of 1.55 or above for the prevalence of immunoglobulin (IgG) antibodies against cLPS at a significance level of alpha = 0.05.

RESULTS

Prevalence of IgG antibodies against cLPS was not different between cases and controls (61% vs. 62%; p = 0.7). The adjusted OR for the presence of CAD given positive IgG serostatus against cLPS was 0.9 (95% CI; 0.6 to 1.3). Similarly, no difference in the prevalence of IgG antibodies against CP was seen (88% vs. 87%; p = 0.6); the adjusted OR was 1.0 (95% CI; 0.6 to 1.6). Markers of inflammation did not show any statistically significant difference between cLPS seropositives and seronegatives.

CONCLUSIONS

Our results indicate no strong association between CP and CAD, and increased systemic inflammation in patients with CAD does not seem to be due to seropositivity to cLPS or CP.

Abbreviations and Acronyms
  BMI = body mass index
  CAD = coronary artery disease
  cLPS = chlamydial lipopolysaccharide
  CP = Chlamydia pneumoniae
  CRP = C-reactive protein
  ELISA = enzyme linked immunoassay
  IgG/A/M = immunoglobulin G/A/M
  MIF = microimmunofluorescence




This article has been cited by other articles:


Home page
 Arch Intern MedHome page
A. Spahr, E. Klein, N. Khuseyinova, C. Boeckh, R. Muche, M. Kunze, D. Rothenbacher, G. Pezeshki, A. Hoffmeister, and W. Koenig
Periodontal Infections and Coronary Heart Disease: Role of Periodontal Bacteria and Importance of Total Pathogen Burden in the Coronary Event and Periodontal Disease (CORODONT) Study.
Arch Intern Med, March 13, 2006; 166(5): 554 - 559.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
D. Rothenbacher, S. Muller-Scholze, C. Herder, W. Koenig, and H. Kolb
Differential Expression of Chemokines, Risk of Stable Coronary Heart Disease, and Correlation with Established Cardiovascular Risk Markers
Arterioscler. Thromb. Vasc. Biol., January 1, 2006; 26(1): 194 - 199.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
C. Monaco, E. Rossi, D. Milazzo, F. Citterio, F. Ginnetti, G. D'Onofrio, D. Cianflone, F. Crea, L. M. Biasucci, and A. Maseri
Persistent systemic inflammation in unstable angina is largely unrelated to the atherothrombotic burden
J. Am. Coll. Cardiol., January 18, 2005; 45(2): 238 - 243.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
D. J. Angiolillo, G. Liuzzo, S. Pelliccioni, E. De Candia, R. Landolfi, F. Crea, A. Maseri, and L. M. Biasucci
Combined role of the Lewis antigenic system, Chlamydia pneumoniae, and C-reactive protein in unstable angina
J. Am. Coll. Cardiol., February 19, 2003; 41(4): 546 - 550.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
W. Koenig, N. Khuseyinova, M. M. Hoffmann, W. Marz, M. Frohlich, A. Hoffmeister, H. Brenner, and D. Rothenbacher
CD14 C(-260)->T polymorphism, plasma levels of the soluble endotoxin receptor CD14, their association with chronic infections and risk of stable coronary artery disease
J. Am. Coll. Cardiol., July 3, 2002; 40(1): 34 - 42.
[Abstract] [Full Text] [PDF]

Home page
 CVIHome page
C. Stollberger and J. Finsterer
Role of Infectious and Immune Factors in Coronary and Cerebrovascular Arteriosclerosis
Clin. Vaccine Immunol., March 1, 2002; 9(2): 207 - 215.
[Full Text] [PDF]

Home page
 Eur Heart J SupplHome page
A. Maseri and D. Cianflone
Inflammation in acute coronary syndromes
Eur. Heart J. Suppl., March 1, 2002; 4(suppl_B): B8 - B13.
[Abstract] [PDF]

Home page
 StrokeHome page
S. C. Johnston, L. M. Messina, W. S. Browner, M. T. Lawton, C. Morris, and D. Dean
C-Reactive Protein Levels and Viable Chlamydia pneumoniae in Carotid Artery Atherosclerosis
Stroke, December 1, 2001; 32(12): 2748 - 2752.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
Y. Momiyama, R. Hirano, H. Taniguchi, H. Nakamura, and F. Ohsuzu
Effects of interleukin-1 gene polymorphisms on the development of coronary artery disease associated with Chlamydia pneumoniae infection
J. Am. Coll. Cardiol., September 1, 2001; 38(3): 712 - 717.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
G. Liuzzo, D. J. Angiolillo, A. Buffon, V. Rizzello, C. Colizzi, F. Ginnetti, L. M. Biasucci, and A. Maseri
Enhanced Response of Blood Monocytes to In Vitro Lipopolysaccharide-Challenge in Patients With Recurrent Unstable Angina
Circulation, May 8, 2001; 103(18): 2236 - 2241.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Microbiol.Home page
A. Schumacher, A. B. Lerkerød, I. Seljeflot, L. Sommervoll, I. Holme, J. E. Otterstad, and H. Arnesen
Chlamydia pneumoniae Serology: Importance of Methodology in Patients with Coronary Heart Disease and Healthy Individuals
J. Clin. Microbiol., May 1, 2001; 39(5): 1859 - 1864.
[Abstract] [Full Text]

Home page
 JWatch GeneralHome page
Unrecognized MI Remains Common Among Elderly
Journal Watch (General), January 18, 2000; 2000(118): 7 - 7.
[Full Text]


HOME SUBSCRIPTIONS CURRENT ISSUE PAST ISSUES CARDIOSOURCE SEARCH HELP FEEDBACK
Copyright © 2000 by the American College of Cardiology Foundation.