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CLINICAL STUDIES

Complications of endomyocardial biopsy in children

^a Division of Pediatric Cardiology, Children’s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA

Manuscript received February 2, 1998; revised manuscript received July 2, 1999, accepted August 27, 1999.

Reprint requests and correspondence: Dr. Stephen G. Pophal, Division of Pediatric Cardiology, Rush Children’s Heart Center, 1653 West Congress Parkway, Chicago, Illinois 60612
spophal{at}rush.edu

OBJECTIVES

To evaluate the incidence of, and risk factors for, complications of endomyocardial biopsy in children.

BACKGROUND

Endomyocardial biopsy (EMB) is a low risk procedure in adults, but there is a paucity of data with regard to performing this procedure in children.

METHODS

Retrospective review of the morbidity and mortality of 1,000 consecutive EMB procedures.

RESULTS

One thousand EMB procedures (right ventricle 986, left ventricle 14) were performed on 194 patients from July 1987 through March 1996. Indications for EMB included heart transplant rejection surveillance (846) and the evaluation of cardiomyopathy or arrhythmia for possible myocarditis (154). Thirty-seven (4%) procedures were performed on patients receiving intravenous inotropic support. There was one biopsy related death, secondary to cardiac perforation, in a two-week-old infant with dilated cardiomyopathy. There were nine perforations of the right ventricle, eight occurring in patients with dilated cardiomyopathy and one in a transplant recipient. The transplant patient did not require immediate intervention; two patients required pericardiocentesis alone, and six underwent pericardiocentesis and surgical intervention. All nine perforations were from the femoral venous approach (p < 0.01). Multivariate analysis demonstrated that the greatest risk of perforation occurred in children being evaluated for possible myocarditis (p = 0.01) and in those requiring inotropic support (p < 0.01). Other complications included arrhythmia (5) and single cases of coronary-cardiac fistula, flail tricuspid leaflet, pneumothorax, hemothorax, endocardial stripping and seizure.

CONCLUSIONS

Risk of endomyocardial biopsy is highest in sick children with suspected myocarditis on inotropic support. However, EMB can be performed safely with very low morbidity in pediatric heart transplant recipients.

Abbreviations and Acronyms   EMB = endomyocardial biopsy   F = French (catheter size)

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