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CLINICAL STUDIES

Propensity and mechanisms of restenosis in different coronary stent designs

Complementary value of the analysis of the luminal gain-loss relationship

^a Interventional Cardiology Unit, San Carlos University Hospital, Madrid, Spain

Manuscript received October 5, 1998; revised manuscript received May 18, 1999, accepted June 29, 1999.

Reprint requests and correspondence: Dr. Javier Escaned, Unidad de Cardiología Intervencionista, Hospital Clinico Universitario San Carlos, Prof. Martin Lagos S/N, 28040 Madrid, Spain

OBJECTIVES

This study sought to investigate the influence of stent design on the long-term angiographic outcome.

BACKGROUND

The proportional relationship between vessel injury and late luminal loss in percutaneous revascularization should be best appreciated in coronary stenting, where recoil and shrinkage are theoretically minimal. It is unclear whether all stent designs can counterbalance this reactive loss by achieving a large initial luminal gain (bigger is better).

METHODS

In 523 lesions successfully stented, the long-term angiographic results of slotted-tube (n = 331), coil (n = 85), multicellular (n = 70) and self-expandable mesh (n = 37) stent designs were compared using the angiographic gain-loss relationship (GLR).

RESULTS

Restenosis rate was 10% for multicellular, 20% for slotted-tube, 46% for coil and 49% for self-expandable designs (p = 0.001). At a difference with other designs, no significant GLR was found in coil stents, suggesting additional mechanisms of luminal loss (i.e., plaque protrusion, stent compression) to neointimal proliferation. Significant differences in late loss between stents were found within each quartile of luminal gain, suggesting a specific role of design in luminal loss. Multivariate analysis identified use of coil and self-expandable stents, vessel size, minimal luminal diameter preintervention, luminal gain and stent length as variables with independent predictive value for several indices of angiographic long-term outcome.

CONCLUSIONS

The analysis of GLR: 1) demonstrates that stent design influences late luminal loss; 2) challenges the applicability of the widely accepted "bigger is better" approach to all stent designs; and 3) appears as a valuable tool in assessing long-term stent performance.

Abbreviations and Acronyms   MLD = minimal luminal diameter   PTCA = percutaneous transluminal coronary angioplasty

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