Advertisement

Submit Manuscripts
Author Information
Subscribe/Renew
Order Reprints
Email Alerts
Feedback
RSS Feed
CME

About the Journal
Editorial Board & Staff

About JACC CME
Hardware/Software Requirements
Contact Us
Policy on Privacy and Confidentiality
Copyright Information

JACC Imaging Homepage JACC Interventions Homepage
Still not a subscriber to JACC Imaging or JACC Interventions?
Click here
to sign up now!

ACC.org
Cardiosmart
Cardiosource
CVN
Imaging Library
JACC Imaging
JACC Interventions

Click here for more guidelines.
2009 Focused Updates: ACC/AHA Guidelines for STEMI and ACC/AHA/SCAI Guidelines for PCI
2009 ACCF/AHA Focused Update on Perioperative Beta Blockade Incorporated Into the ACC/AHA 2007 Guidelines on Perioperative Cardiovascular Evaluation and Care for Noncardiac Surgery
ACC 2009 Advocacy Position Statement: Principles for Comparative Effectiveness Research
CME Topic Collections Past Issues Search Current Issue Home
     

J Am Coll Cardiol, 1999; 33:1506-1511
© 1999 by the American College of Cardiology Foundation
This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by O’Driscoll, G.
Right arrow Articles by Taylor, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by O’Driscoll, G.
Right arrow Articles by Taylor, R.

CLINICAL STUDIES

Improvement in endothelial function by angiotensin-converting enzyme inhibition in non–insulin-dependent diabetes mellitus

Gerard O’Driscoll, MB, BCh, BAO, FRACPa, Daniel Green, PhD{dagger}, Andrew Maiorana, MSc{dagger}, Kim Stanton, MB, BS, FRACP*, Frances Colreavy, MB, BCh, BAO, FFARCSIa and Roger Taylor, MB, BS, FRACP{ddagger}

a Departments of Cardiology and Endocrinology, Royal Perth Hospital, Nedlands, Australia
* Department of Diabetes, Royal Perth Hospital, Nedlands, Australia
{dagger} Department of Human Movement, The University of Western Australia, Nedlands, Australia
{ddagger} Department of Medicine, The University of Western Australia, Nedlands, Australia

Manuscript received August 18, 1998; revised manuscript received January 5, 1999, accepted January 21, 1999.

Reprint requests and correspondence: Dr. Danny Green, Department of Human Movement, The University of Western Australia, Nedlands 6907, Western Australia, Australia
brevis{at}cyllene.uwa.edu.au

OBJECTIVES

The aim of this study was to assess the effect of angiotensin-converting enzyme (ACE) inhibition with enalapril on forearm endothelial function in subjects with type II diabetes mellitus.

BACKGROUND

Endothelial function is depressed in the presence of conventional risk factors for atherosclerosis, and various therapies, such as lipid-lowering therapy in hypercholesterolemia, can improve endothelial-mediated vasodilation. ACE inhibition has improved such function in several conditions including type I diabetes, but there is no evidence for a beneficial effect in type II diabetes.

METHODS

The influence of enalapril (10 mg twice daily for 4 weeks) on endothelium-dependent and -independent vasodilator function was determined in 10 type II diabetic subjects using a double-blinded placebo-controlled crossover protocol. Forearm blood flow was measured using strain-gage plethysmography and graded intrabrachial infusion of acetylcholine (ACh), NG-monomethyl-L-arginine (LNMMA) and sodium nitroprusside (SNP).

RESULTS

Enalapril increased the response to the endothelium-dependent vasodilator, ACh (p < 0.02) and the vasoconstrictor response to the nitric oxide (NO) synthase inhibitor, LNMMA (p < 0.002). No difference was evident in the response to SNP.

CONCLUSIONS

In type II diabetic subjects without evidence of vascular disease, the ACE inhibitor enalapril improved stimulated and basal NO-dependent endothelial function. The study extends the spectrum of beneficial effects demonstrated to result from ACE inhibition in diabetes.

Abbreviations and Acronyms
  ACE = angiotensin-converting enzyme
  ACh = acetylcholine
  FBF = forearm blood flow
  FVR = forearm vascular resistance
  LNMMA = NG-monomethyl-L-arginine
  NO = nitric oxide
  SNP = sodium nitroprusside
  TREND = Trial on Reversing Endothelial Dysfunction




This article has been cited by other articles:


Home page
 Diabetes CareHome page
J. Dawson, T. Quinn, C. Harrow, K. R. Lees, C. J. Weir, S. J. Cleland, and M. R. Walters
Allopurinol and Nitric Oxide Activity in the Cerebral Circulation of Those With Diabetes: A randomized trial
Diabetes Care, January 1, 2009; 32(1): 135 - 137.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
A. J. Flammer, I. Sudano, F. Hermann, S. Gay, A. Forster, M. Neidhart, P. Kunzler, F. Enseleit, D. Periat, M. Hermann, et al.
Angiotensin-Converting Enzyme Inhibition Improves Vascular Function in Rheumatoid Arthritis
Circulation, April 29, 2008; 117(17): 2262 - 2269.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
F. Palm, M. L. Onozato, Z. Luo, and C. S. Wilcox
Dimethylarginine dimethylaminohydrolase (DDAH): expression, regulation, and function in the cardiovascular and renal systems
Am J Physiol Heart Circ Physiol, December 1, 2007; 293(6): H3227 - H3245.
[Abstract] [Full Text] [PDF]

Home page
 Diabetes and Vascular Disease ResearchHome page
S. J Hamilton, G. T Chew, and G. F Watts
Therapeutic regulation of endothelial dysfunction in type 2 diabetes mellitus
Diabetes and Vascular Disease Research, June 1, 2007; 4(2): 89 - 102.
[Abstract] [PDF]

Home page
 Diabetes and Vascular Disease ResearchHome page
J. M. Lee, C. Shirodaria, C. E Jackson, M. D Robson, C. Antoniades, J. M Francis, F. Wiesmann, K. M Channon, S. Neubauer, and R. P Choudhury
Multi-modal magnetic resonance imaging quantifies atherosclerosis and vascular dysfunction in patients with type 2 diabetes mellitus
Diabetes and Vascular Disease Research, March 1, 2007; 4(1): 44 - 48.
[Abstract] [PDF]

Home page
 British Journal of Diabetes & Vascular DiseaseHome page
E. Gkaliagkousi, A. Shah, and A. Ferro
Review: Pharmacological and non-pharmacological treatment of endothelial dysfunction: relevance to diabetes
The British Journal of Diabetes & Vascular Disease, January 1, 2007; 7(1): 5 - 10.
[Abstract] [PDF]

Home page
 DiabetesHome page
J.-H. Oak and H. Cai
Attenuation of Angiotensin II Signaling Recouples eNOS and Inhibits Nonendothelial NOX Activity in Diabetic Mice
Diabetes, January 1, 2007; 56(1): 118 - 126.
[Abstract] [Full Text] [PDF]

Home page
 Diabetes and Vascular Disease ResearchHome page
I. L Williams, P. J Chowienczyk, S. B Wheatcroft, A. G Patel, R. A Sherwood, A. M Shah, and M. T Kearney
Divergent effects of angiotensin-converting enzyme inhibition on blood pressure and endothelial function in obese humans
Diabetes and Vascular Disease Research, May 1, 2006; 3(1): 34 - 38.
[Abstract] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
T. S. Hermann, W. Li, H. Dominguez, N. Ihlemann, C. Rask-Madsen, A. Major-Pedersen, D. B. Nielsen, K. W. Hansen, M. Hawkins, L. Kober, et al.
Quinapril Treatment Increases Insulin-Stimulated Endothelial Function and Adiponectin Gene Expression in Patients with Type 2 Diabetes
J. Clin. Endocrinol. Metab., March 1, 2006; 91(3): 1001 - 1008.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
J. B. Meigs, C. J. O'Donnell, G. H. Tofler, E. J. Benjamin, C. S. Fox, I. Lipinska, D. M. Nathan, L. M. Sullivan, R. B. D'Agostino, and P. W.F. Wilson
Hemostatic Markers of Endothelial Dysfunction and Risk of Incident Type 2 Diabetes: The Framingham Offspring Study
Diabetes, February 1, 2006; 55(2): 530 - 537.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
S. Watanabe, T. Tagawa, K. Yamakawa, M. Shimabukuro, and S. Ueda
Inhibition of the Renin-Angiotensin System Prevents Free Fatty Acid-Induced Acute Endothelial Dysfunction in Humans
Arterioscler Thromb Vasc Biol, November 1, 2005; 25(11): 2376 - 2380.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
Y. Taniyama, H. Hitomi, A. Shah, R. W. Alexander, and K. K. Griendling
Mechanisms of Reactive Oxygen Species-Dependent Downregulation of Insulin Receptor Substrate-1 by Angiotensin II
Arterioscler Thromb Vasc Biol, June 1, 2005; 25(6): 1142 - 1147.
[Abstract] [Full Text] [PDF]

Home page
 Eur J Heart FailHome page
D. R. Morgan, L. J. Dixon, C. G. Hanratty, S. M.T. Hughes, W. J. Leahey, K. P. Rooney, G. D. Johnston, and G. E. McVeigh
Impaired endothelium-dependent and -independent vasodilation in elderly patients with chronic heart failure
Eur J Heart Fail, December 1, 2004; 6(7): 901 - 908.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
D. J Green, A. Maiorana, G. O'Driscoll, and R. Taylor
Effect of exercise training on endothelium-derived nitric oxide function in humans
J. Physiol., November 15, 2004; 561(1): 1 - 25.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
K. Watts, P. Beye, A. Siafarikas, E. A. Davis, T. W. Jones, G. O'Driscoll, and D. J. Green
Exercise training normalizes vascular dysfunction and improves central adiposity in obese adolescents
J. Am. Coll. Cardiol., May 19, 2004; 43(10): 1823 - 1827.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
F. Andreozzi, E. Laratta, A. Sciacqua, F. Perticone, and G. Sesti
Angiotensin II Impairs the Insulin Signaling Pathway Promoting Production of Nitric Oxide by Inducing Phosphorylation of Insulin Receptor Substrate-1 on Ser312 and Ser616 in Human Umbilical Vein Endothelial Cells
Circ. Res., May 14, 2004; 94(9): 1211 - 1218.
[Abstract] [Full Text] [PDF]

Home page
 JAMAHome page
J. B. Meigs, F. B. Hu, N. Rifai, and J. E. Manson
Biomarkers of Endothelial Dysfunction and Risk of Type 2 Diabetes Mellitus
JAMA, April 28, 2004; 291(16): 1978 - 1986.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
F. B. Hu, J. B. Meigs, T. Y. Li, N. Rifai, and J. E. Manson
Inflammatory Markers and Risk of Developing Type 2 Diabetes in Women
Diabetes, March 1, 2004; 53(3): 693 - 700.
[Abstract] [Full Text] [PDF]

Home page
 ANN INTERN MEDHome page
R. T. Hurst and R. W. Lee
Increased Incidence of Coronary Atherosclerosis in Type 2 Diabetes Mellitus: Mechanisms and Management
Ann Intern Med, November 18, 2003; 139(10): 824 - 834.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
A. K. Trauernicht, H. Sun, K. P. Patel, and W. G. Mayhan
Enalapril Prevents Impaired Nitric Oxide Synthase-Dependent Dilatation of Cerebral Arterioles in Diabetic Rats
Stroke, November 1, 2003; 34(11): 2698 - 2703.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart JHome page
J. H. Walsh, G. Yong, C. Cheetham, G. F. Watts, G. J. O'Driscoll, R. R. Taylor, and D. J. Green
Effects of exercise training on conduit and resistance vessel function in treated and untreated hypercholesterolaemic subjects
Eur. Heart J., September 2, 2003; 24(18): 1681 - 1689.
[Abstract] [Full Text] [PDF]

Home page
 Nephrol Dial TransplantHome page
F. Locatelli, B. Canaud, K.-U. Eckardt, P. Stenvinkel, C. Wanner, and C. Zoccali
The importance of diabetic nephropathy in current nephrological practice
Nephrol. Dial. Transplant., September 1, 2003; 18(9): 1716 - 1725.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. H. Walsh, W. Bilsborough, A. Maiorana, M. Best, G. J. O'Driscoll, R. R. Taylor, and D. J. Green
Exercise training improves conduit vessel function in patients with coronary artery disease
J Appl Physiol, July 1, 2003; 95(1): 20 - 25.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
J. T. Kuvin and R. H. Karas
Clinical Utility of Endothelial Function Testing: Ready for Prime Time?
Circulation, July 1, 2003; 107(25): 3243 - 3247.
[Full Text] [PDF]

Home page
 Journal of Renin-Angiotensin-Aldosterone SystemHome page
H. Tezcan, D. Yavuz, A. Toprak, I. Akpmar, M. Koc, O. Deyneli, and S. Akalm
Effect of angiotensin-converting enzyme inhibition on endothelial function and insulin sensitivity in hypertensive patients
Journal of Renin-Angiotensin-Aldosterone System, June 1, 2003; 4(2): 119 - 123.
[Abstract] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
P. O. Bonetti, L. O. Lerman, and A. Lerman
Endothelial Dysfunction: A Marker of Atherosclerotic Risk
Arterioscler Thromb Vasc Biol, February 1, 2003; 23(2): 168 - 175.
[Abstract] [Full Text] [PDF]

Home page
 JNMHome page
A. Kjaer, C. Meyer, F. S. Nielsen, H.-H. Parving, and B. Hesse
Dipyridamole, Cold Pressor Test, and Demonstration of Endothelial Dysfunction: A PET Study of Myocardial Perfusion in Diabetes
J. Nucl. Med., January 1, 2003; 44(1): 19 - 23.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart J SupplHome page
F. Enseleit, T.F. Luscher, and F. Ruschitzka
Angiotensin-converting enzyme inhibition and endothelial dysfunction: focus on ramipril
Eur. Heart J. Suppl., January 1, 2003; 5(suppl_A): A31 - A36.
[Abstract] [PDF]

Home page
 British Journal of Diabetes & Vascular DiseaseHome page
S. P Marso
Review: The pathogenesis of type 2 diabetes and cardiovascular disease
The British Journal of Diabetes & Vascular Disease, September 1, 2002; 2(5): 350 - 356.
[Abstract] [PDF]

Home page
 Journal of Renin-Angiotensin-Aldosterone SystemHome page
J. Davies and A. Struthers
Review: The potential benefits of aldosterone antagonism in Type 2 diabetes mellitus
Journal of Renin-Angiotensin-Aldosterone System, September 1, 2002; 3(3): 150 - 155.
[Abstract] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
D. Green, C. Cheetham, L. Mavaddat, K. Watts, M. Best, R. Taylor, and G. O'Driscoll
Effect of lower limb exercise on forearm vascular function: contribution of nitric oxide
Am J Physiol Heart Circ Physiol, September 1, 2002; 283(3): H899 - H907.
[Abstract] [Full Text] [PDF]

Home page
 British Journal of Diabetes & Vascular DiseaseHome page
E. Nicolaides and C. J. Jones
Review: Type 2 diabetes -- implications for macrovascular mechanics and disease
The British Journal of Diabetes & Vascular Disease, January 1, 2002; 2(1): 9 - 12.
[Abstract] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
Y. Arad, D. Newstein, F. Cadet, M. Roth, and A. D. Guerci
Association of Multiple Risk Factors and Insulin Resistance With Increased Prevalence of Asymptomatic Coronary Artery Disease by an Electron-Beam Computed Tomographic Study
Arterioscler Thromb Vasc Biol, December 1, 2001; 21(12): 2051 - 2058.
[Abstract] [Full Text] [PDF]

Home page
 HeartHome page
R D Rakhit and M S Marber
Nitric oxide: an emerging role in cardioprotection?
Heart, October 1, 2001; 86(4): 368 - 372.
[Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
A. Maiorana, G. O'Driscoll, C. Cheetham, L. Dembo, K. Stanton, C. Goodman, R. Taylor, and D. Green
The effect of combined aerobic and resistance exercise training on vascular function in type 2 diabetes
J. Am. Coll. Cardiol., September 1, 2001; 38(3): 860 - 866.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
R. J. Woodman, D. A. Playford, G. F. Watts, C. Cheetham, C. Reed, R. R. Taylor, I. B. Puddey, L. J. Beilin, V. Burke, T. A. Mori, et al.
Improved analysis of brachial artery ultrasound using a novel edge-detection software system
J Appl Physiol, August 1, 2001; 91(2): 929 - 937.
[Abstract] [Full Text] [PDF]

Home page
 Nephrol Dial TransplantHome page
A. Asberg, K. Midtvedt, T. Vassbotn, and A. Hartmann
Better microvascular function on long-term treatment with lisinopril than with nifedipine in renal transplant recipients
Nephrol. Dial. Transplant., July 1, 2001; 16(7): 1465 - 1470.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
J. Calles-Escandon and M. Cipolla
Diabetes and Endothelial Dysfunction: A Clinical Perspective
Endocr. Rev., February 1, 2001; 22(1): 36 - 52.
[Abstract] [Full Text]

Home page
 HypertensionHome page
J. M. A. van Ampting, M. L. Hijmering, J. J. Beutler, R. E. van Etten, H. A. Koomans, T. J. Rabelink, and E. S. G. Stroes
Vascular Effects of ACE Inhibition Independent of the Renin-Angiotensin System in Hypertensive Renovascular Disease : A Randomized, Double-Blind, Crossover Trial
Hypertension, January 1, 2001; 37(1): 40 - 45.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
C. Cheetham, J. Collis, G. O'Driscoll, K. Stanton, R. Taylor, and D. Green
Losartan, an angiotensin type 1 receptor antagonist, improves endothelial function in non-insulin-dependent diabetes
J. Am. Coll. Cardiol., November 1, 2000; 36(5): 1461 - 1466.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
A. Maiorana, G. O'Driscoll, L. Dembo, C. Cheetham, C. Goodman, R. Taylor, and D. Green
Effect of aerobic and resistance exercise training on vascular function in heart failure
Am J Physiol Heart Circ Physiol, October 1, 2000; 279(4): H1999 - H2005.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
D.W. Laight, M.J. Carrier, and E.E. Anggard
Antioxidants, diabetes and endothelial dysfunction
Cardiovasc Res, August 18, 2000; 47(3): 457 - 464.
[Abstract] [Full Text] [PDF]


 
  CME Topic Collections Past Issues Search Current Issue Home

Advertisement