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CLINICAL STUDIES

Human atrial repolarization: effects of sinus rate, pacing and drugs on the surface electrocardiogram

Nadia M. G. Debbas, MD, PhD, FESC, FACC^a, Steve H. D. Jackson, MD, Daniel de Jonghe, MD^a, Annie Robert and A. John Camm, MD, PhD, FESC, FACC

^a Department of Cardiology, Cliniques Universitaires St Luc, UCL, Brussels, Belgium
Department of Epidemiology, Cliniques Universitaires St Luc, UCL, Brussels, Belgium
Department of Cardiological Sciences, St George’s Hospital Medical School, London, England, United Kingdom

Manuscript received March 20, 1998; revised manuscript received August 4, 1998, accepted October 2, 1998.

Reprint requests and correspondence: Dr. Nadia M.G. Debbas, Department of Cardiology, Cliniques Universitaires St Luc, 1200 Bruxelles, Belgium
debbas{at}card.ucl.ac.be

Objectives

We studied the effects of rate and some cardioactive drugs on the atrial surface electrocardiogram (ECG).

Background

In atrioventricular block, atrial surface ECG is unmasked. The effect of rate alone permits detection of the effect of other exogenous stimulations such as drugs in the presence of rate alterations.

Methods

High fidelity, high gain ECG leads I, II and III were recorded from 51 patients with heart block. Durations of P and Ta waves and the total PTa interval were measured from nonconducted atrial events.

Results

No relationship was found between sinus cycle length and PTa, P or Ta in 31 patients. In 20 patients, progressively decreasing the atrial pacing cycle length from 853 ms to 381 ms resulted in a linear reduction of the PTa interval from 444 to 291 ms (rho = 0.76, slope = 0.24). This was largely due to shortening of Ta. A linear rate correction formula was derived: corrected PTa = PTa – 0.24 (PP – 1000). Atropine (0.02 mg/kg) shortened the PP interval (p < 0.001) and the PTa interval (p < 0.01). Propranolol (0.1 mg/kg) prolonged the PP interval (p < 0.001) but did not alter the PTa interval. Neither disopyramide (2.0 mg/kg) nor flecainide acetate (2.0 mg/kg) altered the PP interval, but both prolonged the PTa interval (p < 0.001). This was largely due to P wave lengthening after flecainide (p < 0.001) and to Ta prolongation after disopyramide (p < 0.001).

Conclusions

In heart block, PTa, P and Ta waves can be measured reliably. The effects of pacing and some antiarrhythmic drugs on the atrial myocardium are similar to those known at the ventricular level.

Abbreviations and Acronyms   AV = atrioventricular   CV = coefficient of variation   ECG = electrocardiogram/electrocardiographic   MAP = monophasic action potential

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