Advertisement

Submit Manuscripts
Author Information
Subscribe/Renew
Order Reprints
Email Alerts
Feedback
RSS Feed
CME

About the Journal
Editorial Board & Staff

JACC Imaging Homepage JACC Interventions Homepage
Still not a subscriber to JACC Imaging or JACC Interventions?
Click here
to sign up now!

ACC.org
Cardiosmart
Cardiosource
CVN
Imaging Library
JACC Imaging
JACC Interventions

Click here for more guidelines.
ACCF/ASNC/ACR/
AHA/ASE/SCCT/
SCMR/SNM 2009 Appropriate Use Criteria for Cardiac Radionuclide Imaging
SCIENCE ADVISORY: Percutaneous Device Closure of Patent Foramen Ovale for Secondary Stroke Prevention
ACCF/AHA 2009 Expert Consensus Document on Pulmonary Hypertension
CME Topic Collections Past Issues Search Current Issue Home
     

J Am Coll Cardiol, 1998; 32:2072-2079
© 1998 by the American College of Cardiology Foundation
This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kwon, H. M.
Right arrow Articles by Schwartz, R. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kwon, H. M.
Right arrow Articles by Schwartz, R. S.

EXPERIMENTAL STUDIES

Adventitial vasa vasorum in balloon-injured coronary arteries

Visualization and quantitation by a microscopic three-dimensional computed tomography technique

Hyuck Moon Kwon, MDa, Giuseppe Sangiorgi, MDa, Erik L. Ritman, MD, PhD*, Amir Lerman, MDa, Charles McKenna, MDa, Renu Virmani, MD{ddagger}, William D. Edwards, MD{dagger}, David R. Holmes, MDa and Robert S. Schwartz, MDa

a Department of Internal Medicine and Cardiovascular Diseases, Mayo Clinic and Mayo Foundation, Rochester, Minnesota, USA
* Department of Physiology and Biophysics, Mayo Clinic and Mayo Foundation, Rochester, Minnesota, USA
{dagger} Division of Medical Pathology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota, USA
{ddagger} Department of Cardiovascular Pathology, Armed Force Institute of Pathology, Washington, DC, USA

Manuscript received October 28, 1997; revised manuscript received July 1, 1998, accepted August 20, 1998.

Address for correspondence: Robert S. Schwartz, MD, Department of Cardiovascular Diseases, Mayo Clinic, 200 First St., SW, Rochester, MN 55905
schwartzr{at}mayo.edu

Objectives. The objective of this study was to examine the quantitative response of the adventitial vasa vasorum to balloon-induced coronary injury.

Background. Recent attention has focused on the role of vasa vasorum in atherosclerotic and restenotic coronary artery disease. However, the three-dimensional anatomy of these complex vessels is largely unknown, especially after angioplasty injury. The purpose of this study was to visualize and quantitate three-dimensional spatial patterns of vasa vasorum in normal and balloon injured porcine coronary arteries. We also studied the spatial growth of vasa vasorum in regions of neointimal formation. A novel imaging technique, microscopic computed tomography, was used for these studies.

Methods. Four pigs were killed 28 d after coronary balloon injury, and four pigs with uninjured coronary arteries served as normal controls. The coronary arteries were injected with a low-viscosity, radiopaque liquid polymer compound. Normal and injured coronary segments were scanned using a microscopic computed tomography technique. Three-dimensional reconstructed maximum intensity projection and voxel gradient shading images were displayed at different angles and voxel threshold values, using image analysis software. For quantitation, seven to 10 cross-sectional images (40 normal and 32 balloon injured cross-sections) were captured from each specimen at a voxel size of 21 µm.

Results. Normal vasa vasorum originated from the coronary artery lumen, principally at large branch points. Two different types of vasa were found and classified as first-order or second-order according to location and direction. In balloon-injured coronary arteries, adventitial vasa vasorum density was increased (3.16 ± 0.17/mm2 vs. 1.90 ± 0.06/mm2, p = 0.0001; respectively), suggesting neovascularization by 28 d after vessel injury. Also, in these injured arteries, the vasa spatial distribution was disrupted compared with normal vessels, with proportionally more second-order vasa vasorum. The diameters of first-order and second-order vasa were smaller in normal compared with balloon-treated coronary arteries (p = 0.012 first-order; p < 0.001, second-order; respectively). The density of newly formed vasa vasorum was proportional to vessel stenosis (r = 0.81, p = 0.0001). Although the total number of vasa was increased after injury, the total vascular area comprised of vasa was significantly reduced in injured vessels compared with normals (3.83 ± 0.20% to 5.42 ± 0.56%, p = 0.0185).

Conclusions. Adventitial neovascularization occurs after balloon injury. The number of new vessels is proportional to vessel stenosis. These findings may hold substantial implications for the therapy of vascular disease and restenosis.

Abbreviations and Acronyms
  CT = computed tomography
  PTCA = coronary angioplasty
  3D = three-dimensional




This article has been cited by other articles:


Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
M. Simons
VEGF and Restenosis: The Rest of the Story
Arterioscler. Thromb. Vasc. Biol., April 1, 2009; 29(4): 439 - 440.
[Full Text] [PDF]

Home page
 J CARDIOVASC PHARMACOL THERHome page
M. K. Reddy, J. K. Vasir, G. V. Hegde, S. S. Joshi, and V. Labhasetwar
Erythropoietin Induces Excessive Neointima Formation: A Study in a Rat Carotid Artery Model of Vascular Injury
Journal of Cardiovascular Pharmacology and Therapeutics, September 1, 2007; 12(3): 237 - 247.
[Abstract] [PDF]

Home page
 Cardiovasc ResHome page
E. L. Ritman and A. Lerman
The dynamic vasa vasorum
Cardiovasc Res, September 1, 2007; 75(4): 649 - 658.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
S. Kawatsu, K. Oda, Y. Saiki, Y. Tabata, and K. Tabayashi
External Application of Rapamycin-Eluting Film at Anastomotic Sites Inhibits Neointimal Hyperplasia in a Canine Model
Ann. Thorac. Surg., August 1, 2007; 84(2): 560 - 567.
[Abstract] [Full Text] [PDF]

Home page
 Eur J EchocardiogrHome page
O. Gulel, I. Sipahi, E. Murat Tuzcu, and S. Kapadia
Coronary artery wall enhances with intracoronary injection of echocontrast media during in vivo intravascular ultrasound
Eur J Echocardiogr, June 1, 2007; 8(3): 234 - 236.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
J.-B. Michel, O. Thaunat, X. Houard, O. Meilhac, G. Caligiuri, and A. Nicoletti
Topological Determinants and Consequences of Adventitial Responses to Arterial Wall Injury
Arterioscler. Thromb. Vasc. Biol., June 1, 2007; 27(6): 1259 - 1268.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
J. Herrmann and A. Lerman
Atherosclerosis in the Back Yard
J. Am. Coll. Cardiol., May 29, 2007; 49(21): 2102 - 2104.
[Abstract] [Full Text] [PDF]

Home page
 Nephrol Dial TransplantHome page
B. Kelly, M. Melhem, J. Zhang, G. Kasting, J. Li, M. Krishnamoorthy, S. Heffelfinger, S. Rudich, P. Desai, and P. Roy-Chaudhury
Perivascular paclitaxel wraps block arteriovenous graft stenosis in a pig model
Nephrol. Dial. Transplant., September 1, 2006; 21(9): 2425 - 2431.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
J. Herrmann, L. O. Lerman, D. Mukhopadhyay, C. Napoli, and A. Lerman
Angiogenesis in Atherogenesis
Arterioscler. Thromb. Vasc. Biol., September 1, 2006; 26(9): 1948 - 1957.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
A. N. Cheema, T. Hong, N. Nili, A. Segev, J. G. Moffat, K. E. Lipson, A. R. Howlett, D. W. Holdsworth, M. J. Cole, B. Qiang, et al.
Adventitial Microvessel Formation After Coronary Stenting and the Effects of SU11218, a Tyrosine Kinase Inhibitor
J. Am. Coll. Cardiol., March 7, 2006; 47(5): 1067 - 1075.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart JHome page
A. Lerman and E. Eeckhout
Coronary endothelial dysfunction following sirolimus-eluting stent placement: should we worry about it?
Eur. Heart J., January 2, 2006; 27(2): 125 - 126.
[Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
R. Savai, J. C. Wolf, S. Greschus, B. G. Eul, R. T. Schermuly, J. Hanze, R. Voswinckel, A. C. Langheinrich, F. Grimminger, H. Traupe, et al.
Analysis of Tumor Vessel Supply in Lewis Lung Carcinoma in Mice by Fluorescent Microsphere Distribution and Imaging with Micro- and Flat-Panel Computed Tomography
Am. J. Pathol., October 1, 2005; 167(4): 937 - 946.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
R. Khurana, M. Simons, J. F. Martin, and I. C. Zachary
Role of Angiogenesis in Cardiovascular Disease: A Critical Appraisal
Circulation, September 20, 2005; 112(12): 1813 - 1824.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
A. Lerman
Restenosis: Another "Dysfunction" of the Endothelium
Circulation, January 4, 2005; 111(1): 8 - 10.
[Full Text] [PDF]

Home page
 CirculationHome page
I. Shiojima and K. Walsh
The Role of Vascular Endothelial Growth Factor in Restenosis: The Controversy Continues
Circulation, October 19, 2004; 110(16): 2283 - 2286.
[Full Text] [PDF]

Home page
 CirculationHome page
R. Khurana, Z. Zhuang, S. Bhardwaj, M. Murakami, E. De Muinck, S. Yla-Herttuala, N. Ferrara, J. F. Martin, I. Zachary, and M. Simons
Angiogenesis-Dependent and Independent Phases of Intimal Hyperplasia
Circulation, October 19, 2004; 110(16): 2436 - 2443.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
R. S. Schwartz, N. A. Chronos, and R. Virmani
Preclinical restenosis models and drug-eluting stents: Still important, still much to learn
J. Am. Coll. Cardiol., October 6, 2004; 44(7): 1373 - 1385.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
X. Lu, A. Pandit, and G. S. Kassab
Biaxial incremental homeostatic elastic moduli of coronary artery: two-layer model
Am J Physiol Heart Circ Physiol, October 1, 2004; 287(4): H1663 - H1669.
[Abstract] [Full Text] [PDF]

Home page
 ANGIOLOGYHome page
M. R. Dashwood, R. Anand, A. Loesch, and D. S.R. Souza
Hypothesis: A Potential Role for the Vasa Vasorum in the Maintenance of Vein Graft Patency
Angiology, July 1, 2004; 55(4): 385 - 395.
[Abstract] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
N. J. Davie, J. T. Crossno Jr., M. G. Frid, S. E. Hofmeister, J. T. Reeves, D. M. Hyde, T. C. Carpenter, J. A. Brunetti, I. K. McNiece, and K. R. Stenmark
Hypoxia-induced pulmonary artery adventitial remodeling and neovascularization: contribution of progenitor cells
Am J Physiol Lung Cell Mol Physiol, April 1, 2004; 286(4): L668 - L678.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
P. Delafontaine, Y.-H. Song, and Y. Li
Expression, Regulation, and Function of IGF-1, IGF-1R, and IGF-1 Binding Proteins in Blood Vessels
Arterioscler. Thromb. Vasc. Biol., March 1, 2004; 24(3): 435 - 444.
[Abstract] [Full Text]

Home page
 Cardiovasc ResHome page
C. Monaco and E. Paleolog
Nuclear factor {kappa}B: a potential therapeutic target in atherosclerosis and thrombosis
Cardiovasc Res, March 1, 2004; 61(4): 671 - 682.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
K. Pels, C. Deiner, S. E Coupland, M. Noutsias, A. P Sutter, H.-P. Schultheiss, S. Yla-Herttuala, and P. L Schwimmbeck
Effect of adventitial VEGF165 gene transfer on vascular thickening after coronary artery balloon injury
Cardiovasc Res, December 1, 2003; 60(3): 664 - 672.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
X. Lu, J. Yang, J. B. Zhao, H. Gregersen, and G. S. Kassab
Shear modulus of porcine coronary artery: contributions of media and adventitia
Am J Physiol Heart Circ Physiol, November 1, 2003; 285(5): H1966 - H1975.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
A. Farb, D. K. Weber, F. D. Kolodgie, A. P. Burke, and R. Virmani
Morphological Predictors of Restenosis After Coronary Stenting in Humans
Circulation, June 25, 2002; 105(25): 2974 - 2980.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
P. R. Moreno, K. R. Purushothaman, V. Fuster, and W. N. O'Connor
Intimomedial Interface Damage and Adventitial Inflammation Is Increased Beneath Disrupted Atherosclerosis in the Aorta: Implications for Plaque Vulnerability
Circulation, May 28, 2002; 105(21): 2504 - 2511.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
J. Herrmann, P. J. Best, E. L. Ritman, D. R. Holmes Jr, L. O. Lerman, and A. Lerman
Chronic endothelin receptor antagonism prevents coronary vasa vasorum neovascularization in experimental hypercholesterolemia
J. Am. Coll. Cardiol., May 1, 2002; 39(9): 1555 - 1561.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
M. D. Bentley, M. C. Ortiz, E. L. Ritman, and J. C. Romero
The use of microcomputed tomography to study microvasculature in small rodents
Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2002; 282(5): R1267 - R1279.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
S. H. Wilson, J. Herrmann, L. O. Lerman, D. R. Holmes Jr, C. Napoli, E. L. Ritman, and A. Lerman
Simvastatin Preserves the Structure of Coronary Adventitial Vasa Vasorum in Experimental Hypercholesterolemia Independent of Lipid Lowering
Circulation, January 29, 2002; 105(4): 415 - 418.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
I. Fishbein, M. Chorny, S. Banai, A. Levitzki, H. D. Danenberg, J. Gao, X. Chen, E. Moerman, I. Gati, V. Goldwasser, et al.
Formulation and Delivery Mode Affect Disposition and Activity of Tyrphostin-Loaded Nanoparticles in the Rat Carotid Model
Arterioscler. Thromb. Vasc. Biol., September 1, 2001; 21(9): 1434 - 1439.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
J. Herrmann, L. O Lerman, M. Rodriguez-Porcel, D. R Holmes Jr., D. M Richardson, E. L Ritman, and A. Lerman
Coronary vasa vasorum neovascularization precedes epicardial endothelial dysfunction in experimental hypercholesterolemia
Cardiovasc Res, September 1, 2001; 51(4): 762 - 766.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
E. F Unger
Experimental evaluation of coronary collateral development
Cardiovasc Res, February 16, 2001; 49(3): 497 - 506.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
R. S. Scotland, P. J.T. Vallance, and A. Ahluwalia
Endogenous factors involved in regulation of tone of arterial vasa vasorum: implications for conduit vessel physiology
Cardiovasc Res, June 1, 2000; 46(3): 403 - 411.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
M. Hoher, J. Wohrle, M. Wohlfrom, H. Hanke, R. Voisard, H. H. Osterhues, M. Kochs, S. N. Reske, V. Hombach, and J. Kotzerke
Intracoronary {beta}-Irradiation With a Liquid 188Re-Filled Balloon : Six-Month Results From a Clinical Safety and Feasibility Study
Circulation, May 23, 2000; 101(20): 2355 - 2360.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
A. Bayes-Genis, C. A. Conover, and R. S. Schwartz
The Insulin-Like Growth Factor Axis : A Review of Atherosclerosis and Restenosis
Circ. Res., February 4, 2000; 86(2): 125 - 130.
[Abstract] [Full Text] [PDF]

Home page
 J CARDIOVASC PHARMACOL THERHome page
B. D. Klugherz, N. Meneveau, W. Chen, F. Wade-Whittaker, G. Papandreou, R. Levy, and R. L. Wilensky
Sustained Intramural Retention and Regional Redistribution Following Local Vascular Delivery of Polylactic-Coglycolic Acid and Liposomal Nanoparticulate Formulations Containing Probucol
Journal of Cardiovascular Pharmacology and Therapeutics, January 1, 1999; 4(3): 167 - 174.
[Abstract] [PDF]


 
  CME Topic Collections Past Issues Search Current Issue Home

Advertisement