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CLINICAL STUDIES

Mechanical debulking versus balloon angioplasty for the treatment of true bifurcation lesions

^a Cardiovascular Division, Beth Israel–Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
^* Cardiovascular Division, West Roxbury Veterans Administration Medical Center, and Harvard Medical School, Boston, Massachusetts, USA

Manuscript received February 12, 1998; revised manuscript received June 22, 1998, accepted August 6, 1998.

Address for correspondence: Dr. David J. Cohen, Cardiovascular Division, Beth Israel–Deaconess Medical Center, 330 Brookline Avenue, Boston, Massachusetts 02215
djc{at}hsph.harvard.edu

Objectives. The purpose of this study was to compare the immediate angiographic and long-term results of debulking versus balloon angioplasty for treatment of true bifurcation lesions.

Background. Previous studies have shown true bifurcation lesions to be a high risk morphological subset for percutaneous transluminal coronary angioplasty (PTCA). Although atherectomy devices have been used to treat bifurcation lesions, no studies have compared the outcomes of these alternative treatment modalities.

Methods. Between January 1992 and May 1997, we treated 70 consecutive patients with true bifurcation lesions (defined as a greater than 50% stenosis in both the parent vessel and contiguous side branch) with conventional PTCA (n = 30) or debulking (with rotational or directional atherectomy) plus adjunctive PTCA (n = 40). Paired angiograms were analyzed by quantitative angiography, and clinical follow-up was obtained in all patients.

Results. Acute procedural success was 73% in the PTCA group and 97% in the debulking group (p = 0.01). Major in-hospital complications occurred in two patients in the PTCA group and one in the debulking group. Treatment with atherectomy plus PTCA resulted in lower postprocedure residual stenoses than PTCA alone (16 ± 15% vs. 33 ± 17% in the parent vessel, and 6 ± 15% vs. 39 ± 22% in the side branch; p < 0.001 for both comparisons). At 1 year follow-up, the incidence of target vessel revascularization (TVR) was 53% in the PTCA group as compared with 28% in the debulking group (p = 0.05). Independent predictors of the need for repeat TVR were side branch diameter >2.3 mm, longer lesion lengths, and treatment with PTCA alone.

Conclusions. For the treatment of true bifurcation lesions, atherectomy with adjunctive PTCA is safe, improves acute angiographic results, and decreases target vessel revascularization compared to PTCA alone. The benefits of debulking for bifurcation lesions were especially seen in lesions involving large side branches.

Abbreviations and Acronyms   CABG = coronary artery bypass grafting   DCA = directional atherectomy   MI = myocardial infarction   MLD = minimum lumen diameter   PTCA = percutaneous transluminal coronary angioplasty   TVR = target vessel revascularization

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