CLINICAL STUDIES
Noninvasive assessment of coronary flow velocity and coronary flow velocity reserve in the left anterior descending coronary artery by Doppler echocardiography
Comparison with invasive technique
Takeshi Hozumi, MDa,
Kiyoshi Yoshida, MD, FACCa,
Takashi Akasaka, MDa,
Yoshio Asami, MDa,
Yumiko Ogata, MDa,
Tsutomu Takagi, MDa,
Shuichiro Kaji, MDa,
Takahiro Kawamoto, MDa,
Yoshiaki Ueda, MDa and
Shigefumi Morioka, MDa
a Division of Cardiology, Kobe General Hospital, Kobe, Japan
Manuscript received March 27, 1998;
revised manuscript received June 25, 1998,
accepted July 15, 1998.
Address for correspondence: Dr. Takeshi Hozumi, Division of Cardiology, Kobe General Hospital, 4-6 Minatojima-nakamachi, Chuo-ku, Kobe 650, Japan
jse{at}warp.or.jp
Objectives. The purpose of this study was to evaluate whether transthoracic Doppler echocardiography (TTDE) can reliably measure coronary flow velocity (CFV) and coronary flow velocity reserve (CFVR) in the left anterior descending coronary artery (LAD) in the clinical setting.
Background. Coronary flow velocity measurement has provided useful clinical and physiologic information. Advancement in TTDE provides noninvasive measurement of CFV and CFVR in the distal LAD.
Methods. In 23 patients, CFV in the distal LAD was measured by TTDE (5 or 3.5 MHz) under the guidance of color Doppler flow mapping at the time of Doppler guide wire (DGW) examination. Coronary flow velocity in the distal LAD were measured at baseline and hyperemic conditions (intravenous administration of adenosine 0.14 mg/kg/min) by both TTDE and DGW techniques. Coronary flow velocity reserve was defined as the ratio of peak hyperemic to basal averaged peak velocity in the distal LAD.
Results. Clear envelopes of basal and hyperemic CFV in the distal LAD were obtained in 18 (78%) of 23 study patients by TTDE. There were excellent correlations between TTDE and DGW methods for the measurements of CFV (averaged peak velocity: r = 0.97, y = 0.94x + 0.40; averaged diastolic peak velocity: r = 0.97, y = 0.94x + 0.69; systolic peak velocities: r = 0.97, y = 0.91x + 0.87; diastolic peak velocity: r = 0.98, y = 0.95x + 1.10). Coronary flow velocity reserve from TTDE correlated highly with those from DGW examinations (r = 0.94, y = 0.95x + 0.21).
Conclusions. Noninvasive measurement of CFV and CFVR in the distal LAD using TTDE accurately reflects invasive measurement of CFV and CFVR by DGW method.
|
Abbreviations and Acronyms
| | ADPV | = averaged diastolic peak velocity | | APV | = averaged peak velocity | | ASPV | = averaged systolic peak velocity | | CFV | = coronary flow velocity | | CFVR | = coronary flow velocity reserve | | DGW | = Doppler guide wire | | DPV | = diastolic peak velocity | | LAD | = left anterior descending coronary artery | | TTDE | = transthoracic Doppler echocardiography |
|
This article has been cited by other articles:
|
|
|
|
 
A. Cassar, P. Chareonthaitawee, C. S. Rihal, A. Prasad, R. J. Lennon, L. O. Lerman, and A. Lerman
Lack of Correlation Between Noninvasive Stress Tests and Invasive Coronary Vasomotor Dysfunction in Patients With Nonobstructive Coronary Artery Disease
Circ Cardiovasc Interv,
June 1, 2009;
2(3):
237 - 244.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Sicari
Risk stratification by stress echocardiography beyond wall motion analysis.
J. Am. Coll. Cardiol. Img.,
March 1, 2009;
2(3):
260 - 262.
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Momen, V. Mascarenhas, A. Gahremanpour, Z. Gao, R. Moradkhan, A. Kunselman, J. P. Boehmer, L. I. Sinoway, and U. A. Leuenberger
Coronary blood flow responses to physiological stress in humans
Am J Physiol Heart Circ Physiol,
March 1, 2009;
296(3):
H854 - H861.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Meimoun and C. Tribouilloy
Non-invasive assessment of coronary flow and coronary flow reserve by transthoracic Doppler echocardiography: a magic tool for the real world
Eur J Echocardiogr,
July 1, 2008;
9(4):
449 - 457.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M Saito, H Okayama, K Nishimura, A Ogimoto, T Ohtsuka, K Inoue, G Hiasa, T Sumimoto, and J Higaki
Possible link between large artery stiffness and coronary flow velocity reserve
Heart,
June 1, 2008;
94(6):
e20 - e20.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Valzania, F. Gadler, R. Winter, F. Braunschweig, L.-A. Brodin, P. Gudmundsson, G. Boriani, and M. J. Eriksson
Effects of cardiac resynchronization therapy on coronary blood flow: Evaluation by transthoracic Doppler echocardiography
Eur J Heart Fail,
May 1, 2008;
10(5):
514 - 520.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H Oe, T Hozumi, E Murata, H Matsuura, K Negishi, Y Matsumura, S Iwata, K Ogawa, K Sugioka, Y Takemoto, et al.
Arachidonic acid and docosahexaenoic acid supplementation increases coronary flow velocity reserve in Japanese elderly individuals
Heart,
March 1, 2008;
94(3):
316 - 321.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Rigo, R. Sicari, S. Gherardi, A. Djordjevic-Dikic, L. Cortigiani, and E. Picano
The additive prognostic value of wall motion abnormalities and coronary flow reserve during dipyridamole stress echo
Eur. Heart J.,
January 1, 2008;
29(1):
79 - 88.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. Ikonomidis, J. T. Parissis, I. Paraskevaidis, K. Kourea, V. Bistola, J. Lekakis, G. Filippatos, and D. Th. Kremastinos
Effects of levosimendan on coronary artery flow and cardiac performance in patients with advanced heart failure
Eur J Heart Fail,
December 1, 2007;
9(12):
1172 - 1177.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. M. Vigano, M. Turiel, V. Martina, E. Meregalli, L. Tomasoni, G. De Blasio, L. Delfino, A. Edefonti, P. Grillo, M. Procaccio, et al.
Reduced coronary flow reserve in young adults with renal transplant
Nephrol. Dial. Transplant.,
August 1, 2007;
22(8):
2328 - 2333.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. H. Aburawi, A. Berg, P. Liuba, and E. Pesonen
Effects of cardiopulmonary bypass surgery on coronary flow in children assessed with transthoracic Doppler echocardiography
Am J Physiol Heart Circ Physiol,
August 1, 2007;
293(2):
H1138 - H1143.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Erdogan, H. Gullu, M. Caliskan, O. Ciftci, S. Baycan, A. Yildirir, and H. Muderrisoglu
Nebivolol improves coronary flow reserve in patients with idiopathic dilated cardiomyopathy
Heart,
March 1, 2007;
93(3):
319 - 324.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Momen, A. Gahremanpour, A. Mansoor, A. Kunselman, C. Blaha, W. Pae, U. A. Leuenberger, and L. I. Sinoway
Vasoconstriction seen in coronary bypass grafts during handgrip in humans
J Appl Physiol,
February 1, 2007;
102(2):
735 - 739.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Leschka, S. Wildermuth, T. Boehm, L. Desbiolles, L. Husmann, A. Plass, P. Koepfli, T. Schepis, B. Marincek, P. A. Kaufmann, et al.
Noninvasive Coronary Angiography with 64-Section CT: Effect of Average Heart Rate and Heart Rate Variability on Image Quality
Radiology,
November 1, 2006;
241(2):
378 - 385.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D Erdogan, H Gullu, M Caliskan, I Yildirim, D Tok, and H Muderrisoglu
Coronary flow reserve is preserved in white-coat hypertension
Heart,
August 1, 2006;
92(8):
1109 - 1112.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. O. Kiviniemi, A. Snapir, M. Saraste, J. O. Toikka, O. T. Raitakari, M. Ahotupa, J. J. Hartiala, M. Scheinin, and J. W. Koskenvuo
Determinants of coronary flow velocity reserve in healthy young men
Am J Physiol Heart Circ Physiol,
August 1, 2006;
291(2):
H564 - H569.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Saraste, V. Kyto, M. Saraste, T. Vuorinen, J. Hartiala, and P. Saukko
Coronary flow reserve and heart failure in experimental coxsackievirus myocarditis. A transthoracic Doppler echocardiography study
Am J Physiol Heart Circ Physiol,
August 1, 2006;
291(2):
H871 - H875.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T Hozumi, K Sugioka, K Shimada, S H Kim, M Y Kuo, Y Miyake, K Fujimoto, R Otsuka, H Watanabe, K Hosoda, et al.
Beneficial effect of short term intake of red wine polyphenols on coronary microcirculation in patients with coronary artery disease.
Heart,
May 1, 2006;
92(5):
681 - 682.
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. A.L. Ahmari, K. Modesto, J. Bunch, V. Stussy, A. Dichak, J. Seward, P. Pellikka, and K. Chandrasekaran
Doppler derived coronary flow reserve during dobutamine stress echocardiography further improves detection of myocardial ischemia
Eur J Echocardiogr,
March 1, 2006;
7(2):
134 - 140.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T Kawata, M Daimon, R Hasegawa, K Teramoto, T Toyoda, T Sekine, K Yamamoto, D Uchida, T Himi, K Yoshida, et al.
Serum asymmetric dimethylarginine as a marker of coronary microcirculation in patients with non-insulin dependent diabetes mellitus: correlation with coronary flow reserve
Heart,
December 1, 2005;
91(12):
1607 - 1608.
[Full Text]
[PDF]
|
|
|
|
|
|
|
H Yoshitani, M Takeuchi, K Sakamoto, T Akasaka, K Yoshida, and J Yoshikawa
Effect of one or more co-morbid conditions on diagnostic accuracy of coronary flow velocity reserve for detecting significant left anterior descending coronary stenosis
Heart,
October 1, 2005;
91(10):
1294 - 1298.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
U. Hagg, B. Wandt, G. Bergstrom, R. Volkmann, and L.-m. Gan
Physical exercise capacity is associated with coronary and peripheral vascular function in healthy young adults
Am J Physiol Heart Circ Physiol,
October 1, 2005;
289(4):
H1627 - H1634.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M Turiel, R Peretti, P Sarzi-Puttini, F Atzeni, and A Doria
Cardiac imaging techniques in systemic autoimmune diseases
Lupus,
September 1, 2005;
14(9):
727 - 731.
[Abstract]
[PDF]
|
|
|
|
|
|
|
R. Florenciano-Sanchez, G. de la Morena-Valenzuela, M. Villegas-Garcia, F. Soria-Arcos, R. Rubio-Paton, F. Teruel-Carrillo, J. Hurtado, and M. Valdes-Chavarri
Noninvasive assessment of coronary flow velocity reserve in left anterior descending artery adds diagnostic value to both clinical variables and dobutamine echocardiography: a study based on clinical practice
Eur J Echocardiogr,
August 1, 2005;
6(4):
251 - 259.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Sugioka, T. Hozumi, Y. Takemoto, K. Ujino, Y. Matsumura, H. Watanabe, K. Fujimoto, M. Yoshiyama, and J. Yoshikawa
Early recovery of impaired coronary flow reserve by carvedilol therapy in patients with idiopathic dilated cardiomyopathy: A serial transthoracic Doppler echocardiographic study
J. Am. Coll. Cardiol.,
January 18, 2005;
45(2):
318 - 319.
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Voci, F. Pizzuto, and F. Romeo
Coronary flow: a new asset for the echo lab?
Eur. Heart J.,
November 1, 2004;
25(21):
1867 - 1879.
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Iwakura, H. Ito, S. Kawano, A. Okamura, K. Tanaka, Y. Nishida, Y. Maekawa, and K. Fujii
Assessing myocardial perfusion with the transthoracic Doppler technique in patients with reperfused anterior myocardial infarction: comparison with angiographic, enzymatic and electrocardiographic indices
Eur. Heart J.,
September 1, 2004;
25(17):
1526 - 1533.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A Hagendorff, A Werner, D Pfeiffer, and H Becher
Estimation of vasodilator response by analysis of Doppler intensity kinetics with myocardial contrast echocardiography using an intravenous standardized bolus administration
Eur J Echocardiogr,
August 1, 2004;
5(4):
272 - 283.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. O. Kiviniemi, M. Saraste, J. W. Koskenvuo, K. E. J. Airaksinen, J. O. Toikka, A. Saraste, J. P. Parkka, and J. J. Hartiala
Coronary artery diameter can be assessed reliably with transthoracic echocardiography
Am J Physiol Heart Circ Physiol,
April 1, 2004;
286(4):
H1515 - H1520.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Hirata, N. Asaoka, A. Amemiya, S. Hatsuoka, T. Ueno, and Y. Kosakai
Noninvasive evaluation of internal thoracic artery and left anterior descending coronary artery anastomotic sites using transthoracic Doppler echocardiography: comparison with coronary arteriography
J. Thorac. Cardiovasc. Surg.,
October 1, 2003;
126(4):
1080 - 1086.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T Hozumi, Y Kanzaki, Y Ueda, A Yamamuro, T Takagi, T Akasaka, S Homma, K Yoshida, and J Yoshikawa
Coronary flow velocity analysis during short term follow up after coronary reperfusion: use of transthoracic Doppler echocardiography to predict regional wall motion recovery in patients with acute myocardial infarction
Heart,
October 1, 2003;
89(10):
1163 - 1168.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Lethen, H. P. Tries, S. Kersting, and H. Lambertz
Validation of noninvasive assessment of coronary flow velocity reserve in the right coronary artery: A comparison of transthoracic echocardiographic results with intracoronary Doppler flow wire measurements
Eur. Heart J.,
September 1, 2003;
24(17):
1567 - 1575.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Ruscazio, R. Montisci, and S. Iliceto
Expanding the noninvasive coronary physiology assessment with transthoracic Doppler echocardiography
Eur J Echocardiogr,
September 1, 2003;
4(3):
159 - 161.
[Full Text]
[PDF]
|
|
|
|
|
|
|
N Watanabe, T Akasaka, Y Yamaura, M Akiyama, S Kaji, Y Saito, and K Yoshida
Intramyocardial coronary flow characteristics in patients with hypertrophic cardiomyopathy: non-invasive assessment by transthoracic Doppler echocardiography
Heart,
June 1, 2003;
89(6):
657 - 658.
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y Nohtomi, M Takeuchi, K Nagasawa, K Arimura, K Miyata, K Kuwata, T Yamawaki, S Kondo, A Yamada, and S Okamatsu
Persistence of systolic coronary flow reversal predicts irreversible dysfunction after reperfused anterior myocardial infarction
Heart,
April 1, 2003;
89(4):
382 - 388.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Ruscazio, R. Montisci, P. Colonna, C. Caiati, L. Chen, G. Lai, M. Cadeddu, R. Pirisi, and S. Iliceto
Detection of coronary restenosis aftercoronary angioplasty by contrast-enhanced transthoracic echocardiographic Doppler assessment of coronary flow velocity reserve
J. Am. Coll. Cardiol.,
September 4, 2002;
40(5):
896 - 903.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Hozumi, M. Eisenberg, K. Sugioka, A. R. Kokkirala, H. Watanabe, M. Teragaki, J. Yoshikawa, and S. Homma
Change in Coronary Flow Reserve on Transthoracic Doppler Echocardiography after a Single High-Fat Meal in Young Healthy Men
Ann Intern Med,
April 2, 2002;
136(7):
523 - 528.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Hirata, K. Shimada, H. Watanabe, T. Muro, M. Yoshiyama, K. Takeuchi, T. Hozumi, and J. Yoshikawa
Modulation of coronary flow velocity reserve by gender, menstrual cycle and hormone replacement therapy
J. Am. Coll. Cardiol.,
December 1, 2001;
38(7):
1879 - 1884.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Watanabe, T. Akasaka, Y. Yamaura, M. Akiyama, Y. Koyama, N. Kamiyama, Y. Neishi, S. Kaji, Y. Saito, and K. Yoshida
Noninvasive detection of total occlusion of the left anterior descending coronary artery with transthoracic Doppler echocardiography
J. Am. Coll. Cardiol.,
November 1, 2001;
38(5):
1328 - 1332.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Takeuchi, C. Miyazaki, H. Yoshitani, S. Otani, K. Sakamoto, and J. Yoshikawa
Assessment of coronary flow velocity with transthoracic Doppler echocardiography during dobutamine stress echocardiography
J. Am. Coll. Cardiol.,
July 1, 2001;
38(1):
117 - 123.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Pizzuto, P. Voci, E. Mariano, P. Emilio Puddu, G. Sardella, and A. Nigri
Assessment of flow velocity reserve by transthoracic Doppler echocardiography and venous adenosine infusion before and after left anterior descending coronary artery stenting
J. Am. Coll. Cardiol.,
July 1, 2001;
38(1):
155 - 162.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Daimon, H. Watanabe, H. Yamagishi, T. Muro, K. Akioka, K. Hirata, K. Takeuchi, and J. Yoshikawa
Physiologic assessment of coronary artery stenosis by coronary flow reserve measurements with transthoracic doppler echocardiography: comparison with exercise thallium-201 single-photon emission computed tomography
J. Am. Coll. Cardiol.,
April 1, 2001;
37(5):
1310 - 1315.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Leistad, K. Ohmori, T. A. Peterson, G. Christensen, and A. N. DeMaria
Quantitative assessment of myocardial perfusion during graded coronary artery stenoses by intravenous myocardial contrast echocardiography
J. Am. Coll. Cardiol.,
February 1, 2001;
37(2):
624 - 631.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. J. R. Hildick-Smith and L. M. Shapiro
Coronary flow reserve improves after aortic valve replacement for aortic stenosis: an adenosine transthoracic echocardiography study
J. Am. Coll. Cardiol.,
November 15, 2000;
36(6):
1889 - 1896.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D J R Hildick-Smith, P J Johnson, C R Wisbey, E M Winter, and L M Shapiro
Coronary flow reserve is supranormal in endurance athletes: an adenosine transthoracic echocardiographic study
Heart,
October 1, 2000;
84(4):
383 - 389.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
T. Hozumi, K. Yoshida, T. Akasaka, Y. Asami, Y. Kanzaki, Y. Ueda, A. Yamamuro, T. Takagi, and J. Yoshikawa
Value of acceleration flow and the prestenotic to stenotic coronary flow velocity ratio by transthoracic color doppler echocardiography in noninvasive diagnosis of restenosis after percutaneous transluminal coronary angioplasty
J. Am. Coll. Cardiol.,
January 1, 2000;
35(1):
164 - 168.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Voci, G. Testa, G. Plaustro, and Q. Caretta
Coronary Doppler intensity changes during handgrip: a new method to detect coronary vasomotor tone in coronary artery disease
J. Am. Coll. Cardiol.,
August 1, 1999;
34(2):
428 - 434.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
