|
| HOME | SUBSCRIPTIONS | CURRENT ISSUE | PAST ISSUES | CARDIOSOURCE | SEARCH | HELP | FEEDBACK |
|
|
|
|||||||||
|
|||||||||||
|
J Am Coll Cardiol, 1998; 32:921-926 © 1998 by the American College of Cardiology Foundation |
* Division of Cardiology University of Texas Southwestern Medical Center, Dallas, Texas, USA
Division of Cardiology, National Institutes of Health, Bethesda, Maryland, USA
Division of Cardiology, Mayo Clinic, Rochester, Minnesota, USA
Division of Cardiology, Baylor College of Medicine, Houston, Texas, USA
|| Division of Cardiology, Cleveland Clinic, Cleveland, Ohio, USA
Manuscript received May 21, 1998; accepted June 4, 1998.
Address for correspondence: Dr. Imran Afridi, Section of Cardiology (111-A), Veterans Affairs Hospital, 4500 S. Lancaster Road, Dallas, Texas 75216
Afridi{at}ryburn.swmed.edu
Objectives. The purpose of this study was to assess whether the presence or absence of myocardial viability during dobutamine echocardiography (DE) predicts survival in patients with coronary artery disease (CAD) and severe left ventricular (LV) dysfunction.
Background. In patients with CAD, the presence of myocardial viability during DE identifies viable myocardium and predicts recovery of LV systolic function after revascularization. However, there is little data on the relation between myocardial viability and clinical outcome in patients with CAD and severe LV dysfunction.
Methods. We studied 318 patients with CAD and a LV ejection fraction (EF) 
35% who underwent DE and were followed for 18 ± 10 months. Patients were classified into four groups. Group I (n = 85) consisted of patients who had evidence of myocardial viability and subsequently underwent revascularization. Group II (n = 119) consisted of patients with myocardial viability who did not undergo revascularization. Group III (n = 30) consisted of patients who did not have myocardial viability and underwent revascularization. Finally, group IV (n = 84) patients lacked myocardial viability and did not undergo revascularization.
Results. The four groups had similar baseline characteristics and rest LVEF. During follow-up there were 51 deaths (16%). The mortality rate was 6% in group I, 20% in group II, 17% in group III and 20% in group IV (p = 0.01, group I vs. other groups).
Conclusions. In patients with CAD and severe LV dysfunction who demonstrated myocardial viability during DE, revascularization improved survival compared with medical therapy.
| ||||||||||
This article has been cited by other articles:
|
|
 |
|
  J. Chan, F. Khafagi, A. A. Young, B. R. Cowan, C. Thompson, and T. H. Marwick Impact of coronary revascularization and transmural extent of scar on regional left ventricular remodelling Eur. Heart J., July 1, 2008; 29(13): 1608 - 1617. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Sicari, P. Nihoyannopoulos, A. Evangelista, J. Kasprzak, P. Lancellotti, D. Poldermans, J.-U. Voigt, J. L. Zamorano, and on behalf of the European Association of Echocardi Stress echocardiography expert consensus statement: European Association of Echocardiography (EAE) (a registered branch of the ESC) Eur J Echocardiogr, July 1, 2008; 9(4): 415 - 437. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. G. Camici, S. K. Prasad, and O. E. Rimoldi Stunning, Hibernation, and Assessment of Myocardial Viability Circulation, January 1, 2008; 117(1): 103 - 114. [Full Text] [PDF]
|
|
|
|
 |
|
 E. J. Velazquez, K. L. Lee, C. M. O'Connor, J. K. Oh, R. O. Bonow, G. M. Pohost, A. M. Feldman, D. B. Mark, J. A. Panza, G. Sopko, et al. The rationale and design of the Surgical Treatment for Ischemic Heart Failure (STICH) trial. J. Thorac. Cardiovasc. Surg., December 1, 2007; 134(6): 1540 - 1547.e4. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. F.L. Schinkel, D. Poldermans, A. Elhendy, and J. J. Bax Assessment of Myocardial Viability in Patients with Heart Failure J. Nucl. Med., July 1, 2007; 48(7): 1135 - 1146. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A H Gershlick, M de Belder, J Chambers, D Hackett, R Keal, A Kelion, S Neubauer, D J Pennell, M Rothman, M Signy, et al. Role of non-invasive imaging in the management of coronary artery disease: an assessment of likely change over the next 10 years. A report from the British Cardiovascular Society Working Group Heart, April 1, 2007; 93(4): 423 - 431. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V Rizzello, D Poldermans, A F L Schinkel, E Biagini, E Boersma, A Elhendy, F B Sozzi, A Maat, F Crea, J R T C Roelandt, et al. Long term prognostic value of myocardial viability and ischaemia during dobutamine stress echocardiography in patients with ischaemic cardiomyopathy undergoing coronary revascularisation Heart, February 1, 2006; 92(2): 239 - 244. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J M A Swinburn and R Senior Myocardial viability assessed by dobutamine stress echocardiography predicts reduced mortality early after acute myocardial infarction: determining the risk of events after myocardial infarction (DREAM) study Heart, January 1, 2006; 92(1): 44 - 48. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Chareonthaitawee, B. J. Gersh, P. A. Araoz, and R. J. Gibbons Revascularization in Severe Left Ventricular Dysfunction: The Role of Viability Testing J. Am. Coll. Cardiol., August 16, 2005; 46(4): 567 - 574. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. F. Armstrong and W. A. Zoghbi Stress Echocardiography: Current Methodology and Clinical Applications J. Am. Coll. Cardiol., June 7, 2005; 45(11): 1739 - 1747. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R Senior, M Monaghan, H Becher, J Mayet, and P Nihoyannopoulos Stress echocardiography for the diagnosis and risk stratification of patients with suspected or known coronary artery disease: a critical appraisal. Supported by the British Society of Echocardiography Heart, April 1, 2005; 91(4): 427 - 436. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Garot, J. A. C. Lima, B. L. Gerber, S. Sampath, K. C. Wu, D. A. Bluemke, J. L. Prince, and N. F. Osman Spatially Resolved Imaging of Myocardial Function with Strain-encoded MR: Comparison with Delayed Contrast-enhanced MR Imaging after Myocardial Infarction Radiology, November 1, 2004; 233(2): 596 - 602. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J J Bax, E E van der Wall, and M Harbinson Radionuclide techniques for the assessment of myocardial viability and hibernation Heart, August 1, 2004; 90(suppl_5): v26 - v33. [Full Text] [PDF]
|
|
|
|
|
|
M. J Wood and M. H Picard Utility of echocardiography in the evaluation of individuals with cardiomyopathy Heart, June 1, 2004; 90(6): 707 - 712. [Full Text] [PDF]
|
|
|
|
|
|
S.R. Underwood, J. J Bax, J. v. Dahl, M. Y Henein, A. C van Rossum, E. R Schwarz, J.-L. Vanoverschelde, E. E.v. d. Wall, and W. Wijns Imaging techniques for the assessment of myocardial hibernation: Report of a Study Group of the European Society of Cardiology Eur. Heart J., May 2, 2004; 25(10): 815 - 836. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Pitt, D. Dutka, D. Pagano, P. Camici, and R. Bonser The natural history of myocardium awaiting revascularisation in patients with impaired left ventricular function Eur. Heart J., March 2, 2004; 25(6): 500 - 507. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Yang, M. Pu, D. Rodriguez, D. Underwood, B. P. Griffin, V. Kalahasti, J. D. Thomas, and R. C. Brunken Ischemic and viable myocardium in patients with Non-Q-Wave or Q-Wave myocardial infarction and left ventricular dysfunction: A clinical study using positron emission tomography, echocardiography, and electrocardiography J. Am. Coll. Cardiol., February 18, 2004; 43(4): 592 - 598. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Vahlhaus, H.-J. Bruns, J. Stypmann, T. D.T Tjan, F. Janssen, M. Schafers, H. H Scheld, O. Schober, G. Breithardt, and T. Wichter Direct epicardial mapping predicts the recovery of left ventricular dysfunction in chronic ischaemic myocardium Eur. Heart J., January 2, 2004; 25(2): 151 - 157. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Sawada, A. Bapat, D. Vaz, J. Weksler, N. Fineberg, A. Greene, I. Gradus-Pizlo, and H. Feigenbaum Incremental value of myocardial viability for prediction of Long-Term prognosis in surgically revascularized patients with left ventricular dysfunction J. Am. Coll. Cardiol., December 17, 2003; 42(12): 2099 - 2105. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. S. Bach Viability, prognosis, revascularization, and pascal J. Am. Coll. Cardiol., December 17, 2003; 42(12): 2106 - 2108. [Full Text] [PDF]
|
|
|
|
 |
|
 B. P. Griffith Surgical treatment of congestive heart failure: evolving options Ann. Thorac. Surg., December 1, 2003; 76(6): S2254 - 2259. [Full Text] [PDF]
|
|
|
|
|
|
E. J. Eichhorn, P. A. Grayburn, S. A. Mayer, M. St John Sutton, C. Appleton, J. Plehn, J. Oh, B. Greenberg, A. DeMaria, R. Frantz, et al. Myocardial Contractile Reserve by Dobutamine Stress Echocardiography Predicts Improvement in Ejection Fraction With {beta}-Blockade in Patients With Heart Failure: The {beta}-Blocker Evaluation of Survival Trial (BEST) Circulation, November 11, 2003; 108(19): 2336 - 2341. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. D. Cheitlin, W. F. Armstrong, G. P. Aurigemma, G. A. Beller, F. Z. Bierman, J. L. Davis, P. S. Douglas, D. P. Faxon, L. D. Gillam, T. R. Kimball, et al. ACC/AHA/ASE 2003 guideline update for the clinical application of echocardiography: summary article: a report of the American college of cardiology/American heart association task force on practice guidelines (ACC/AHA/ASE committee to update the 1997 guidelines for the clinical application of echocardiography) J. Am. Coll. Cardiol., September 3, 2003; 42(5): 954 - 970. [Full Text] [PDF]
|
|
|
|
|
|
M. D. Cheitlin, W. F. Armstrong, G. P. Aurigemma, G. A. Beller, F. Z. Bierman, J. L. Davis, P. S. Douglas, D. P. Faxon, L. D. Gillam, T. R. Kimball, et al. ACC/AHA/ASE 2003 Guideline Update for the Clinical Application of Echocardiography: Summary Article: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (ACC/AHA/ASE Committee to Update the 1997 Guidelines for the Clinical Application of Echocardiography) Circulation, September 2, 2003; 108(9): 1146 - 1162. [Full Text] [PDF]
|
|
|
|
|
|
J.-L. Monin, J.-P. Quere, M. Monchi, H. Petit, S. Baleynaud, C. Chauvel, C. Pop, P. Ohlmann, C. Lelguen, P. Dehant, et al. Low-Gradient Aortic Stenosis: Operative Risk Stratification and Predictors for Long-Term Outcome: A Multicenter Study Using Dobutamine Stress Hemodynamics Circulation, July 22, 2003; 108(3): 319 - 324. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. L. Mickleborough, N. Merchant, Y. Provost, S. Carson, and J. Ivanov Ventricular reconstruction for ischemic cardiomyopathy Ann. Thorac. Surg., June 1, 2003; 75(90060): S6 - 12. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P E Antunes, J M F. de Oliveira, and M J Antunes Coronary surgery with non-cardioplegic methods in patients with advanced left ventricular dysfunction: immediate and long term results Heart, April 1, 2003; 89(4): 427 - 431. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Balcells, E. R. Powers, W. Lepper, T. Belcik, K. Wei, M. Ragosta, H. Samady, and J. R. Lindner Detection of myocardial viability by contrast echocardiography in acute infarction predicts recovery of resting function and contractile reserve J. Am. Coll. Cardiol., March 5, 2003; 41(5): 827 - 833. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. G. Hundley, T. M. Morgan, C. M. Neagle, C. A. Hamilton, P. Rerkpattanapipat, and K. M. Link Magnetic Resonance Imaging Determination of Cardiac Prognosis Circulation, October 29, 2002; 106(18): 2328 - 2333. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. B. Jacklin, S. F. Barrington, J. C. Roxburgh, G. Jackson, D. Sariklis, P. A. West, and M. N. Maisey Cost-effectiveness of preoperative positron emission tomography in ischemic heart disease Ann. Thorac. Surg., May 1, 2002; 73(5): 1403 - 1409. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. C. Allman, L. J. Shaw, R. Hachamovitch, and J. E. Udelson Myocardial viability testing and impact of revascularization on prognosis in patients with coronary artery disease and left ventricular dysfunction: a meta-analysis J. Am. Coll. Cardiol., April 3, 2002; 39(7): 1151 - 1158. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C Anagnostopoulos, M Y Henein, and S R Underwood Non-invasive investigations: Ischaemic heart disease Br. Med. Bull., October 1, 2001; 59(1): 29 - 44. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Chello, P. Mastroroberto, F. Perticone, F. Cirillo, E. Bevacqua, S. Olivito, and E. Covino Plasma levels of atrial and brain natriuretic peptides as indicators of recovery of left ventricular systolic function after coronary artery bypass Eur. J. Cardiothorac. Surg., July 1, 2001; 20(1): 140 - 146. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R Sicari, A Ripoli, E Picano, A.C Borges, A Varga, W Mathias, L Cortigiani, R Bigi, J Heyman, S Polimeno, et al. The prognostic value of myocardial viability recognized by low dose dipyridamole echocardiography in patients with chronic ischaemic left ventricular dysfunction Eur. Heart J., May 2, 2001; 22(10): 837 - 844. [Abstract] [PDF]
|
|
|
|
|
|
L. L. Mickleborough, S. Carson, and J. Ivanov Repair of dyskinetic or akinetic left ventricular aneurysm: Results obtained with a modified linear closure J. Thorac. Cardiovasc. Surg., April 1, 2001; 121(4): 675 - 682. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Yong, S. F. Nagueh, S. Shimoni, K. Shan, Z.-X. He, M. J. Reardon, G. V. Letsou, J. F. Howell, M. S. Verani, M. A. Quinones, et al. Deceleration Time in Ischemic Cardiomyopathy : Relation to Echocardiographic and Scintigraphic Indices of Myocardial Viability and Functional Recovery After Revascularization Circulation, March 6, 2001; 103(9): 1232 - 1237. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. A. Beller Noninvasive Assessment of Myocardial Viability N. Engl. J. Med., November 16, 2000; 343(20): 1487 - 1490. [Full Text]
|
|
|
|
|
|
R. Sciagra, M. Pellegri, A. Pupi, L. Bolognese, G. Bisi, V. Carnovale, and G. M. Santoro Prognostic implications of Tc-99m sestamibi viability imaging and subsequent therapeutic strategy in patients with chronic coronary artery disease and left ventricular dysfunction J. Am. Coll. Cardiol., September 1, 2000; 36(3): 739 - 745. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G LaCanna, S.H Rahimtoola, O Visioli, R Giubbini, O Alfieri, M Zognio, E Milan, C Ceconi, M Gargano, R LoRusso, et al. Sensitivity, specificity, and predictive accuracies of non-invasive tests, singly and in combination, for diagnosis of hibernating myocardium Eur. Heart J., August 2, 2000; 21(16): 1358 - 1367. [Abstract] [PDF]
|
|
|
|
 |
|
 M E Lewis, M P. Pitt, and R S Bonser Surgical alternatives to mechanical support Perfusion, July 1, 2000; 15(4): 379 - 386. [PDF]
|
|
|
|
|
|
L. L. Mickleborough, S. Carson, M. Tamariz, and J. Ivanov RESULTS OF REVASCULARIZATION IN PATIENTS WITH SEVERE LEFT VENTRICULAR DYSFUNCTION J. Thorac. Cardiovasc. Surg., March 1, 2000; 119(3): 550 - 557. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D Pagano, M E Lewis, J N Townend, P Davies, P G Camici, and R S Bonser Coronary revascularisation for postischaemic heart failure: how myocardial viability affects survival Heart, December 1, 1999; 82(6): 684 - 688. [Abstract] [Full Text]
|
|
|
|
|
|
K. A. Eagle, R. A. Guyton, R. Davidoff, G. A. Ewy, J. Fonger, T. J. Gardner, J. P. Gott, H. C. Herrmann, R. A. Marlow, W. C. Nugent, et al. ACC/AHA guidelines for coronary artery bypass graft surgery: A report of the American College of Cardiology/ American Heart Association task force on Practice Guidelines (Committee to revise the 1991 Guidelines for Coronary Artery Bypass Graft Surgery) J. Am. Coll. Cardiol., October 1, 1999; 34(4): 1262 - 1347. [Full Text] [PDF]
|
|
|
|
|
|
A. Salustri, M. Ciavatti, F. Seccareccia, and A. Palamara Prediction of cardiac events after uncomplicated acute myocardial infarction by clinical variables and dobutamine stress test J. Am. Coll. Cardiol., August 1, 1999; 34(2): 435 - 440. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. J. Bax, D. Poldermans, A. Elhendy, J. H. Cornel, E. Boersma, R. Rambaldi, J. R. T. C. Roelandt, and P. M. Fioretti Improvement of left ventricular ejection fraction, heart failure symptoms and prognosis after revascularization in patients with chronic coronary artery disease and viable myocardium detected by dobutamine stress echocardiography J. Am. Coll. Cardiol., July 1, 1999; 34(1): 163 - 169. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Senior, S. Kaul, and A. Lahiri Myocardial viability on echocardiography predicts long-term survival after revascularization in patients with ischemic congestive heart failure J. Am. Coll. Cardiol., June 1, 1999; 33(7): 1848 - 1854. [Abstract] [Full Text] [PDF]
|
|
| HOME | SUBSCRIPTIONS | CURRENT ISSUE | PAST ISSUES | CARDIOSOURCE | SEARCH | HELP | FEEDBACK |
