EXPERIMENTAL STUDIES
Hypertrophic remodeling: gender differences in the early response to left ventricular pressure overload
Pamela S. Douglas, MD, FACC*,
Sarah E. Katz, BA*,
Ellen O. Weinberg, PhD*,
Ming Hui Chen, MD*,
Sanford P. Bishop, PhD and
Beverly H. Lorell, MD, FACC*
* Cardiovascular Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, USA
Manuscript received March 3, 1998;
revised manuscript received June 2, 1998,
accepted June 12, 1998.
Address for Correspondence: Pamela S. Douglas, MD, Cardiovascular Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Harvard-Thorndike Laboratory, 330 Brookline Avenue, Boston, MA 02215
pdouglas{at}bidmc.harvard.edu
Objectives. To identify gender differences in left ventricular remodeling, hypertrophy, and function in response to pressure overload due to ascending aortic banding in rats.
Background. Gender may influence the adaptation to pressure overload, as women with aortic stenosis have greater degrees of left ventricular hypertrophy and better left ventricular function than men.
Methods. Fifty-two weanling rats underwent ascending aortic banding (16 males, 18 females), or sham surgery (9 males, 9 females). At 6 and 20 weeks, rats underwent transthoracic echo Doppler studies, and closed-chest left ventricular pressures with direct left ventricular puncture. Perfusion-fixed tissues from eight rats were examined morphometrically for myocyte cross-sectional area and percent collagen volume.
Results. At 6 weeks after aortic banding, left ventricular remodeling, extent of hypertrophy, and function appeared similar in male and female rats. At 20 weeks, male but not female rats showed an early transition to heart failure, with onset of cavity dilatation (left ventricular diameter = 155% vs. 121% of same-sex sham), loss of concentric remodeling (relative wall thickness = 102% vs. 139% of sham), elevated wall stress (systolic stress = 266% vs. 154% of sham), and diastolic dysfunction (deceleration of rapid filling = 251% vs. 190% of sham). Left ventricular systolic pressures were higher in female compared with male rats (186 ± 20 vs. 139 ± 13 mm Hg), while diastolic pressures tended to be lower (14 ± 4 vs. 17 ± 4 mm Hg).
Conclusions. Gender significantly influences the evolution of the early response to pressure overload, including the transition to heart failure in rats with aortic stenosis.
|
Abbreviations and Acronyms
| | LV | = left ventricular | | LVH | = left ventricular hypertrophy |
|
This article has been cited by other articles:
|
|
|
|
 
B. Ostadal, I. Netuka, J. Maly, J. Besik, and I. Ostadalova
Gender Differences in Cardiac Ischemic Injury and Protection--Experimental Aspects
Experimental Biology and Medicine,
September 1, 2009;
234(9):
1011 - 1019.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. M. Kawut, N. Al-Naamani, C. Agerstrand, E. Berman Rosenzweig, C. Rowan, R. J. Barst, S. Bergmann, and E. M. Horn
Determinants of Right Ventricular Ejection Fraction in Pulmonary Arterial Hypertension
Chest,
March 1, 2009;
135(3):
752 - 759.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. R. Fermin, A. Barac, S. Lee, S. P. Polster, S. Hannenhalli, T. L. Bergemann, S. Grindle, D. B. Dyke, F. Pagani, L. W. Miller, et al.
Sex and Age Dimorphism of Myocardial Gene Expression in Nonischemic Human Heart Failure
Circ Cardiovasc Genet,
December 1, 2008;
1(2):
117 - 125.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Schulz-Menger, H. Abdel-Aty, A. Rudolph, T. Elgeti, D. Messroghli, W. Utz, P. Boye, S. Bohl, A. Busjahn, B. Hamm, et al.
Gender-specific differences in left ventricular remodelling and fibrosis in hypertrophic cardiomyopathy: Insights from cardiovascular magnetic resonance
Eur J Heart Fail,
September 1, 2008;
10(9):
850 - 854.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. R. Rietzschel, M. Langlois, M. L. De Buyzere, P. Segers, D. De Bacquer, S. Bekaert, L. Cooman, P. Van Oostveldt, P. Verdonck, G. G. De Backer, et al.
Oxidized Low-Density Lipoprotein Cholesterol Is Associated With Decreases in Cardiac Function Independent of Vascular Alterations
Hypertension,
September 1, 2008;
52(3):
535 - 541.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. M. Shioura, D. L. Geenen, and P. H. Goldspink
Sex-related changes in cardiac function following myocardial infarction in mice
Am J Physiol Regulatory Integrative Comp Physiol,
August 1, 2008;
295(2):
R528 - R534.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Matyal
Newly Appreciated Pathophysiology of Ischemic Heart Disease in Women Mandates Changes in Perioperative Management: A Core Review
Anesth. Analg.,
July 1, 2008;
107(1):
37 - 50.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. C. Gillebert and N. R. Van de Veire
About left ventricular torsion, sex differences, shear strain, and diastolic heart failure
Eur. Heart J.,
May 2, 2008;
29(10):
1215 - 1217.
[Full Text]
[PDF]
|
|
|
|
|
|
|
U. H. Frey, W. Lieb, J. Erdmann, D. Savidou, G. Heusch, K. Leineweber, H. Jakob, H.-W. Hense, H. Lowel, N. H. Brockmeyer, et al.
Characterization of the GNAQ promoter and association of increased Gq expression with cardiac hypertrophy in humans
Eur. Heart J.,
April 1, 2008;
29(7):
888 - 897.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. P. Konhilas and L. A. Leinwand
The Effects of Biological Sex and Diet on the Development of Heart Failure
Circulation,
December 4, 2007;
116(23):
2747 - 2759.
[Full Text]
[PDF]
|
|
|
|
|
|
|
Md. S. Bhuiyan, N. Shioda, and K. Fukunaga
Ovariectomy augments pressure overload-induced hypertrophy associated with changes in Akt and nitric oxide synthase signaling pathways in female rats
Am J Physiol Endocrinol Metab,
December 1, 2007;
293(6):
E1606 - E1614.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
X. Loyer, P. Oliviero, T. Damy, E. Robidel, F. Marotte, C. Heymes, and J.-L. Samuel
Effects of sex differences on constitutive nitric oxide synthase expression and activity in response to pressure overload in rats
Am J Physiol Heart Circ Physiol,
November 1, 2007;
293(5):
H2650 - H2658.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. J. Paulus, C. Tschope, J. E. Sanderson, C. Rusconi, F. A. Flachskampf, F. E. Rademakers, P. Marino, O. A. Smiseth, G. De Keulenaer, A. F. Leite-Moreira, et al.
How to diagnose diastolic heart failure: a consensus statement on the diagnosis of heart failure with normal left ventricular ejection fraction by the Heart Failure and Echocardiography Associations of the European Society of Cardiology
Eur. Heart J.,
October 2, 2007;
28(20):
2539 - 2550.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. C. Barbato
Estrogen Receptor Activation--Good, Aldosterone Receptor Blockade--Beneficial, Communication Between Receptors...Priceless
Hypertension,
August 1, 2007;
50(2):
297 - 298.
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. F. Deschepper and B. Llamas
Hypertensive Cardiac Remodeling in Males and Females: From the Bench to the Bedside
Hypertension,
March 1, 2007;
49(3):
401 - 407.
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. K. Podesser, M. Jain, S. Ngoy, C. S. Apstein, and F. R. Eberli
Unveiling gender differences in demand ischemia: a study in a rat model of genetic hypertension
Eur. J. Cardiothorac. Surg.,
February 1, 2007;
31(2):
298 - 304.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. E. Petre, M. P. Quaile, E. I. Rossman, S. J. Ratcliffe, B. A. Bailey, S. R. Houser, and K. B. Margulies
Sex-based differences in myocardial contractile reserve
Am J Physiol Regulatory Integrative Comp Physiol,
February 1, 2007;
292(2):
R810 - R818.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Frielingsdorf, M. Genoni, O. M. Hess, and F. A. Flachskampf
Do women have impaired regional systolic function in hypertensive heart disease? A 3-dimensional echocardiography study
Eur J Echocardiogr,
January 1, 2007;
8(1):
42 - 47.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. K. Chung, S. R. Das, D. Leonard, R. M. Peshock, F. Kazi, S. M. Abdullah, R. M. Canham, B. D. Levine, and M. H. Drazner
Women Have Higher Left Ventricular Ejection Fractions Than Men Independent of Differences in Left Ventricular Volume: The Dallas Heart Study
Circulation,
March 28, 2006;
113(12):
1597 - 1604.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Bridgman, M. A. Aronovitz, R. Kakkar, M. I. Oliverio, T. M. Coffman, W. M. Rand, M. A. Konstam, M. E. Mendelsohn, and R. D. Patten
Gender-specific patterns of left ventricular and myocyte remodeling following myocardial infarction in mice deficient in the angiotensin II type 1a receptor
Am J Physiol Heart Circ Physiol,
August 1, 2005;
289(2):
H586 - H592.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. L. Chancey, J. D. Gardner, D. B. Murray, G. L. Brower, and J. S. Janicki
Modulation of cardiac mast cell-mediated extracellular matrix degradation by estrogen
Am J Physiol Heart Circ Physiol,
July 1, 2005;
289(1):
H316 - H321.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. E. Mendelsohn and R. H. Karas
Molecular and Cellular Basis of Cardiovascular Gender Differences
Science,
June 10, 2005;
308(5728):
1583 - 1587.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Woo, W. G. Williams, R. Choi, E. D. Wigle, E. Rozenblyum, K. Fedwick, S. Siu, A. Ralph-Edwards, and H. Rakowski
Clinical and Echocardiographic Determinants of Long-Term Survival After Surgical Myectomy in Obstructive Hypertrophic Cardiomyopathy
Circulation,
April 26, 2005;
111(16):
2033 - 2041.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Skavdahl, C. Steenbergen, J. Clark, P. Myers, T. Demianenko, L. Mao, H. A. Rockman, K. S. Korach, and E. Murphy
Estrogen receptor-{beta} mediates male-female differences in the development of pressure overload hypertrophy
Am J Physiol Heart Circ Physiol,
February 1, 2005;
288(2):
H469 - H476.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
X.-J. Du
Gender modulates cardiac phenotype development in genetically modified mice
Cardiovasc Res,
August 15, 2004;
63(3):
510 - 519.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. S. Vasan, J. C. Evans, E. J. Benjamin, D. Levy, M. G. Larson, J. Sundstrom, J. M. Murabito, F. Sam, W. S. Colucci, and P. W. F. Wilson
Relations of Serum Aldosterone to Cardiac Structure: Gender-Related Differences in the Framingham Heart Study
Hypertension,
May 1, 2004;
43(5):
957 - 962.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Klapholz, M. Maurer, A. M. Lowe, F. Messineo, J. S. Meisner, J. Mitchell, J. Kalman, R. A. Phillips, R. Steingart, E. J. Brown Jr, et al.
Hospitalization for heart failure in the presence of a normal left ventricular ejection fraction: Results of the New York heart failure registry
J. Am. Coll. Cardiol.,
April 21, 2004;
43(8):
1432 - 1438.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Li, I. Kishimoto, Y. Saito, M. Harada, K. Kuwahara, T. Izumi, I. Hamanaka, N. Takahashi, R. Kawakami, K. Tanimoto, et al.
Androgen Contributes to Gender-Related Cardiac Hypertrophy and Fibrosis in Mice Lacking the Gene Encoding Guanylyl Cyclase-A
Endocrinology,
February 1, 2004;
145(2):
951 - 958.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Lindenfeld, J. K. Ghali, H. J. Krause-Steinrauf, S. Khan, K. Adams Jr, S. Goldman, M. A. Peberdy, C. Yancy, S. Thaneemit-Chen, R. L. Larsen, et al.
Hormone replacement therapy is associated with improved survival in women with advanced heart failure
J. Am. Coll. Cardiol.,
October 1, 2003;
42(7):
1238 - 1245.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
X.-M. Gao, A. Agrotis, D. J. Autelitano, E. Percy, E. A. Woodcock, G. L. Jennings, A. M. Dart, and X.-J. Du
Sex Hormones and Cardiomyopathic Phenotype Induced by Cardiac {beta}2-Adrenergic Receptor Overexpression
Endocrinology,
September 1, 2003;
144(9):
4097 - 4105.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Filippatos and J. T. Parissis
Estrogen administration in patients with chronic heart failure: not ready for prime time
Eur J Heart Fail,
March 1, 2003;
5(2):
113 - 116.
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Dash, A. G Schmidt, A. Pathak, M. J Gerst, D. Biniakiewicz, V. J Kadambi, B. D Hoit, W. T Abraham, and E. G Kranias
Differential regulation of p38 mitogen-activated protein kinase mediates gender-dependent catecholamine-induced hypertrophy
Cardiovasc Res,
March 1, 2003;
57(3):
704 - 714.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. L. Crabbe, K. Dipla, S. Ambati, A. Zafeiridis, J. P. Gaughan, S. R. Houser, and K. B. Margulies
Gender differences in post-infarction hypertrophy in end-stage failing hearts
J. Am. Coll. Cardiol.,
January 15, 2003;
41(2):
300 - 306.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. O. Weinberg, M. Mirotsou, J. Gannon, V. J. Dzau, R. T. Lee, and R. E. Pratt
Sex dependence and temporal dependence of the left ventricular genomic response to pressure overload
Physiol Genomics,
January 15, 2003;
12(2):
113 - 127.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. J. Ho and J. K. Liao
Nonnuclear Actions of Estrogen
Arterioscler Thromb Vasc Biol,
December 1, 2002;
22(12):
1952 - 1961.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Jain, R. Liao, B. K. Podesser, S. Ngoy, C. S. Apstein, and F. R. Eberli
Influence of gender on the response to hemodynamic overload after myocardial infarction
Am J Physiol Heart Circ Physiol,
December 1, 2002;
283(6):
H2544 - H2550.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. R. Freshour, S. E. Chase, and K. L. Vikstrom
Gender differences in cardiac ACE expression are normalized in androgen-deprived male mice
Am J Physiol Heart Circ Physiol,
November 1, 2002;
283(5):
H1997 - H2003.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. J. Ho and J. K. Liao
Non-nuclear Actions of Estrogen: New Targets for Prevention and Treatment of Cardiovascular Disease
Mol. Interv.,
July 1, 2002;
2(4):
219 - 228.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. A Babiker, L. J De Windt, M. van Eickels, C. Grohe, R. Meyer, and P. A Doevendans
Estrogenic hormone action in the heart: regulatory network and function
Cardiovasc Res,
February 15, 2002;
53(3):
709 - 719.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Schwartzbauer and J. Robbins
Matters of Sex: Sex Matters
Circulation,
September 18, 2001;
104(12):
1333 - 1335.
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Guazzi, D. A. Brenner, C. S. Apstein, and K. W. Saupe
Exercise Intolerance in Rats With Hypertensive Heart Disease Is Associated With Impaired Diastolic Relaxation
Hypertension,
February 1, 2001;
37(2):
204 - 208.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. H. Lorell and B. A. Carabello
Left Ventricular Hypertrophy : Pathogenesis, Detection, and Prognosis
Circulation,
July 25, 2000;
102(4):
470 - 479.
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. S. Hayward, R. P. Kelly, and P. Collins
The roles of gender, the menopause and hormone replacement on cardiovascular function
Cardiovasc Res,
April 1, 2000;
46(1):
28 - 49.
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Olivetti, E. Cigola, R. Maestri, C. Lagrasta, D. Corradi, and F. Quaini
Recent advances in cardiac hypertrophy
Cardiovasc Res,
January 1, 2000;
45(1):
68 - 75.
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. O. Weinberg, C. D. Thienelt, S. E. Katz, J. Bartunek, M. Tajima, S. Rohrbach, P. S. Douglas, and B. H. Lorell
Gender differences in molecular remodeling in pressure overload hypertrophy
J. Am. Coll. Cardiol.,
July 1, 1999;
34(1):
264 - 273.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. S. Vasan, M. G. Larson, E. J. Benjamin, J. C. Evans, C. K. Reiss, and D. Levy
Congestive heart failure in subjects with normal versus reduced left ventricular ejection fraction: Prevalence and mortality in a population-based cohort
J. Am. Coll. Cardiol.,
June 1, 1999;
33(7):
1948 - 1955.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
