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CLINICAL STUDIES

Remodeling after directional coronary atherectomy (with and without adjunct percutaneous transluminal coronary angioplasty): a serial angiographic and intravascular ultrasound analysis from the optimal atherectomy restenosis study

^a Intravascular Ultrasound Imaging and Angiographic Core Laboratories, The Washington Hospital Center, Washington, DC, USA

Manuscript received December 9, 1996; revised manuscript received February 26, 1998, accepted April 23, 1998.

Address for correspondence: Dr. Martin B. Leon, Director of Research, Cardiology Research Foundation, 110 Irving Street NW (4B-1), Washington, DC 20010

Objectives. The intravascular ultrasound (IVUS) substudy of OARS (Optimal Atherectomy Restenosis Study) was designed to assess the mechanisms of restenosis after directional coronary atherectomy (DCA).

Background. Recent serial IVUS studies have indicated that late lumen loss after interventional procedures was determined primarily by the direction and magnitude of arterial remodeling, not by cellular proliferation.

Methods. Complete quantitative coronary angiography (QCA) and IVUS were obtained in 104 patients before and after intervention and during follow-up. All studies were performed after administration of 200 µg of intracoronary nitroglycerin. Angiographic measurements included minimum lumen diameter (MLD), interpolated reference diameter and diameter stenosis (DS). Intravascular ultrasound measurements included lesion and reference external elastic membrane (EEM), lumen and plaque+media cross-sectional area (CSA). The axial location of the lesion site was at the smallest follow-up lumen CSA; the reference segment was the most normal-looking cross section within 10 mm proximal to the lesion but distal to any major side branch. Results are reported as mean ± one standard deviation.

Results. The QCA reference decreased from 3.51 ± 0.46 mm to 3.22 ± 0.44 mm; the MLD decreased from 3.22 ± 0.47 mm to 2.03 ± 0.72 mm; and the DS increased from 8 ± 10% to 38 ± 20%. On IVUS, the decrease in lumen CSA (from 8.8 ± 2.5 mm² to 5.5 ± 4.0 mm²) was associated with a significant decrease in EEM (from 19.7 ± 5.6 mm² to 16.9 ± 6.2 mm²); there was no significant increase in P+M (from 10.9 ± 4.2 mm² to 11.3 ± 3.9 mm²). A change in lumen correlated with a change in EEM (r = 0.790, p < 0.0001), not with a change in P+M (r = 0.133, p = 0.2258). A decrease in reference EEM (from 19.1 ± 7.7 mm² to 17.6 ± 8.0 mm²) also correlated with a decrease in lesion EEM (r = 0.665, p < 0.0001). Results in restenotic lesions were similar.

Conclusion. Restenosis after optimal DCA is caused primarily by a decrease in EEM CSA that extends into contiguous reference segments.

Abbreviations and Acronyms   CSA = cross-sectional area   DCA = directional coronary atherectomy   DS = diameter stenosis   EEM = external elastic membrane   IVUS = intravascular ultrasound   MLD = minimum lumen diameter   OARS = Optimal Atherectomy Restenosis Study   P+M = plaque + media   PTCA = percutaneous transluminal coronary angioplasty   QCA = quantitative coronary angiography/angiographic

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