JACC
HOME SUBSCRIPTIONS CURRENT ISSUE PAST ISSUES CARDIOSOURCE SEARCH HELP FEEDBACK
QUICK SEARCH:   [advanced]


     

J Am Coll Cardiol, 1997; 30:1360-1367
© 1997 by the American College of Cardiology Foundation
This Article
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Germano, G
Right arrow Articles by Berman, D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Germano, G
Right arrow Articles by Berman, D.

Automatic quantitation of regional myocardial wall motion and thickening from gated technetium-99m sestamibi myocardial perfusion single-photon emission computed tomography

G Germano, J Erel, H Lewin, PB Kavanagh, and DS Berman

Department of Medicine, Cedars-Sinai Research Institute, Cedars-Sinai Medical Center, University of California Los Angeles School of Medicine, 90048, USA. germano@csmc.edu

OBJECTIVES: We developed an automatic quantitative algorithm for the measurement of regional myocardial wall motion and wall thickening from three-dimensional gated technetium-99m sestamibi myocardial perfusion single-photon emission computed tomographic images. BACKGROUND: The algorithm measures the motion of the three-dimensional endocardial surface using a modification of the centerline method, as well as wall thickening using both geometry (gaussian fit) and partial volume (counts). METHODS: The algorithm was tested using a "variable thickness" heart phantom, and the quantitative results were compared with visual segmental assessment of myocardial motion and thickening in 79 clinical patients with a wide range of ejection fractions (6% to 87%). RESULTS: Phantom measurements of simulated motion and thickening were accurate regardless of the camera used (dual or triple detector), the angular span of reconstructed data (180 degrees or 360 degrees), the amount of motion (3 or 6 mm) or the amount of thickening (33%, 50% or 100%). Quantitative measurements of segmental motion and thickening in the patients were correlated with visual scores (r = 0.668, exact agreement 72.6%, kappa 0.433 and r = 0.550, exact agreement 74.7%, kappa 0.408, respectively). Significant inverse linear relations exist between the global (summed) visual motion score and the average quantitative motion, and between the global (summed) visual thickening score and the average quantitative thickening. Automatic quantitative ejection fraction measurements correlated extremely well with average quantitative motion (r = 0.929) and thickening (r = 0.959). CONCLUSIONS: Our algorithm is accurate and may be the first automatic technique for the quantitative three-dimensional assessment of regional ventricular function in cardiology.


This article has been cited by other articles:


Home page
 Nephrol Dial TransplantHome page
J. J. Dasselaar, R. H. J. A. Slart, M. Knip, J. Pruim, R. A. Tio, C. W. McIntyre, P. E. de Jong, and C. F. M. Franssen
Haemodialysis is associated with a pronounced fall in myocardial perfusion
Nephrol. Dial. Transplant., September 4, 2008; (2008) gfn501v1.
[Abstract] [Full Text] [PDF]

Home page
 JNMHome page
Y. Suzuki, P. J. Slomka, A. Wolak, M. Ohba, S. Suzuki, L. De Yang, G. Germano, and D. S. Berman
Motion-Frozen Myocardial Perfusion SPECT Improves Detection of Coronary Artery Disease in Obese Patients
J. Nucl. Med., July 1, 2008; 49(7): 1075 - 1079.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
J.-S. Choi, K.-B. Kim, W. Han, D. S. Kim, J. S. Park, J. J. Lee, and D. S. Lee
Efficacy of Therapeutic Angiogenesis by Intramyocardial Injection of pCK-VEGF165 in Pigs
Ann. Thorac. Surg., August 1, 2006; 82(2): 679 - 686.
[Abstract] [Full Text] [PDF]

Home page
 J. Nucl. Med. Technol.Home page
G. S. Lin, H. H. Hines, G. Grant, K. Taylor, and C. Ryals
Automated Quantification of Myocardial Ischemia and Wall Motion Defects by Use of Cardiac SPECT Polar Mapping and 4-Dimensional Surface Rendering.
J. Nucl. Med. Technol., March 1, 2006; 34(1): 3 - 17.
[Abstract] [Full Text] [PDF]

Home page
 ICVTSHome page
H. Fujii, H. Ohashi, Y. Tsutsumi, T. Kawai, K. Iino, and M. Onaka
Reverse remodeling after endoventricular circular patch plasty in the mid-term period
Interactive CardioVascular and Thoracic Surgery, December 1, 2005; 4(6): 602 - 605.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
P. M. van der Zee, H. J. Verberne, J. P. van Straalen, G. T.B. Sanders, B. L.F. Van Eck-Smit, R. J. de Winter, and J. C. Fischer
Ischemia-Modified Albumin Measurements in Symptom-Limited Exercise Myocardial Perfusion Scintigraphy Reflect Serum Albumin Concentrations but Not Myocardial Ischemia
Clin. Chem., September 1, 2005; 51(9): 1744 - 1746.
[Full Text] [PDF]

Home page
 JNMHome page
A. Giorgetti, A. Pingitore, B. Favilli, A. Kusch, M. Lombardi, and P. Marzullo
Baseline/Postnitrate Tetrofosmin SPECT for Myocardial Viability Assessment in Patients with Postischemic Severe Left Ventricular Dysfunction: New Evidence from MRI
J. Nucl. Med., August 1, 2005; 46(8): 1285 - 1293.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
A. C. Lapeyre III, E. Klodas, P. J. Rogers, L. J. Sinak, T. C. Hammell, M. K. O'Connor, and R. J. Gibbons
Quantitation of Regional Ejection Fractions Using Gated Tomographic Imaging With 99mTc-Sestamibi
Chest, March 1, 2005; 127(3): 778 - 786.
[Abstract] [Full Text] [PDF]

Home page
 J. Nucl. Med. Technol.Home page
A. K. Paul and H. A. Nabi
Gated Myocardial Perfusion SPECT: Basic Principles, Technical Aspects, and Clinical Applications
J. Nucl. Med. Technol., December 1, 2004; 32(4): 179 - 187.
[Abstract] [Full Text] [PDF]

Home page
 JNMHome page
S. Kasama, T. Toyama, H. Kumakura, Y. Takayama, S. Ichikawa, S. Tange, T. Suzuki, and M. Kurabayashi
Dobutamine Stress 99mTc-Tetrofosmin Quantitative Gated SPECT Predicts Improvement of Cardiac Function After Carvedilol Treatment in Patients with Dilated Cardiomyopathy
J. Nucl. Med., November 1, 2004; 45(11): 1878 - 1884.
[Abstract] [Full Text] [PDF]

Home page
 JNMHome page
P. J. Slomka, H. Nishina, D. S. Berman, X. Kang, C. Akincioglu, J. D. Friedman, S. W. Hayes, U. E. Aladl, and G. Germano
"Motion-Frozen" Display and Quantification of Myocardial Perfusion
J. Nucl. Med., July 1, 2004; 45(7): 1128 - 1134.
[Abstract] [Full Text] [PDF]

Home page
 JNMHome page
V. Go, M. R. Bhatt, and R. C. Hendel
The Diagnostic and Prognostic Value of ECG-Gated SPECT Myocardial Perfusion Imaging
J. Nucl. Med., May 1, 2004; 45(5): 912 - 921.
[Abstract] [Full Text] [PDF]

Home page
 JNMHome page
R. H.J.A. Slart, J. J. Bax, R. M. de Jong, J. de Boer, H. J. Lamb, P. H. Mook, A. T.M. Willemsen, W. Vaalburg, D. J. van Veldhuisen, and P. L. Jager
Comparison of Gated PET with MRI for Evaluation of Left Ventricular Function in Patients with Coronary Artery Disease
J. Nucl. Med., February 1, 2004; 45(2): 176 - 182.
[Abstract] [Full Text] [PDF]

Home page
 JNMHome page
W. J. Kang, D. S. Lee, J. C. Paeng, K.-B. Kim, J.-K. Chung, and M. C. Lee
Prognostic Value of Rest 201Tl-Dipyridamole Stress 99mTc-Sestamibi Gated SPECT for Predicting Patient-Based Clinical Outcomes After Bypass Surgery in Patients with Ischemic Left Ventricular Dysfunction
J. Nucl. Med., November 1, 2003; 44(11): 1735 - 1740.
[Abstract] [Full Text] [PDF]

Home page
 JNMHome page
B. Feng, A. Sitek, and G. T. Gullberg
Calculation of the Left Ventricular Ejection Fraction Without Edge Detection: Application to Small Hearts
J. Nucl. Med., June 1, 2002; 43(6): 786 - 794.
[Abstract] [Full Text] [PDF]

Home page
 JNMHome page
J. Taki, T. Higuchi, K. Nakajima, I. Matsunari, E.-H. Hwang, H. Bunko, M. Kawasuji, G. Watanabe, and N. Tonami
Electrocardiographic Gated 99mTc-MIBI SPECT for Functional Assessment of Patients After Coronary Artery Bypass Surgery: Comparison of Wall Thickening and Wall Motion Analysis
J. Nucl. Med., May 1, 2002; 43(5): 589 - 595.
[Abstract] [Full Text] [PDF]

Home page
 JNMHome page
N. Shirai, H. Yamagishi, M. Yoshiyama, M. Teragaki, K. Akioka, K. Takeuchi, J. Yoshikawa, and H. Ochi
Incremental Value of Assessment of Regional Wall Motion for Detection of Multivessel Coronary Artery Disease in Exercise 201Tl Gated Myocardial Perfusion Imaging
J. Nucl. Med., April 1, 2002; 43(4): 443 - 450.
[Abstract] [Full Text] [PDF]

Home page
 JNMHome page
H. Yamagishi, N. Shirai, M. Yoshiyama, M. Teragaki, K. Akioka, K. Takeuchi, J. Yoshikawa, and H. Ochi
Incremental Value of Left Ventricular Ejection Fraction for Detection of Multivessel Coronary Artery Disease in Exercise 201Tl Gated Myocardial Perfusion Imaging
J. Nucl. Med., February 1, 2002; 43(2): 131 - 139.
[Abstract] [Full Text] [PDF]

Home page
 JNMHome page
T. Sharir, D. S. Berman, P. B. Waechter, J. Areeda, P. B. Kavanagh, J. Gerlach, X. Kang, and G. Germano
Quantitative Analysis of Regional Motion and Thickening by Gated Myocardial Perfusion SPECT: Normal Heterogeneity and Criteria for Abnormality
J. Nucl. Med., November 1, 2001; 42(11): 1630 - 1638.
[Abstract] [Full Text] [PDF]

Home page
 JNMHome page
J. R. Corbett and E. P. Ficaro
Gated SPECT and the Visual Gold Standard: Gold Standard or Not?
J. Nucl. Med., November 1, 2001; 42(11): 1639 - 1642.
[Full Text] [PDF]

Home page
 JNMHome page
K. Nakajima, T. Higuchi, J. Taki, M. Kawano, and N. Tonami
Accuracy of Ventricular Volume and Ejection Fraction Measured by Gated Myocardial SPECT: Comparison of 4 Software Programs
J. Nucl. Med., October 1, 2001; 42(10): 1571 - 1578.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
A. H. Hamawy, L. Y. Lee, S. A. Samy, D. R. Polce, M. Szulc, M. Vazquez, and T. K. Rosengart
Transmyocardial laser revascularization dose response: enhanced perfusion in a porcine ischemia model as a function of channel density
Ann. Thorac. Surg., September 1, 2001; 72(3): 817 - 822.
[Abstract] [Full Text] [PDF]

Home page
 JNMHome page
R. Tanaka and T. Nakamura
Time Course Evaluation of Myocardial Perfusion After Reperfusion Therapy by 99mTc-Tetrofosmin SPECT in Patients with Acute Myocardial Infarction
J. Nucl. Med., September 1, 2001; 42(9): 1351 - 1358.
[Abstract] [Full Text] [PDF]

Home page
 JNMHome page
K. Yoshinaga, K. Morita, S. Yamada, K. Komuro, C. Katoh, Y. Ito, Y. Kuge, T. Kohya, A. Kitabatake, and N. Tamaki
Low-Dose Dobutamine Electrocardiograph-Gated Myocardial SPECT for Identifying Viable Myocardium: Comparison with Dobutamine Stress Echocardiography and PET
J. Nucl. Med., June 1, 2001; 42(6): 838 - 844.
[Abstract] [Full Text] [PDF]

Home page
 JNMHome page
J. C. Paeng, D. S. Lee, G. J. Cheon, M. M. Lee, J.-K. Chung, and M. C. Lee
Reproducibility of an Automatic Quantitation of Regional Myocardial Wall Motion and Systolic Thickening on Gated 99mTc-Sestamibi Myocardial SPECT
J. Nucl. Med., May 1, 2001; 42(5): 695 - 700.
[Abstract] [Full Text]

Home page
 CirculationHome page
P. R. Vale, D. W. Losordo, C. E. Milliken, M. C. McDonald, L. M. Gravelin, C. M. Curry, D. D. Esakof, M. Maysky, J. F. Symes, and J. M. Isner
Randomized, Single-Blind, Placebo-Controlled Pilot Study of Catheter-Based Myocardial Gene Transfer for Therapeutic Angiogenesis Using Left Ventricular Electromechanical Mapping in Patients With Chronic Myocardial Ischemia
Circulation, May 1, 2001; 103(17): 2138 - 2143.
[Abstract] [Full Text] [PDF]

Home page
 JNMHome page
K. Nakajima, J. Taki, M. Kawano, T. Higuchi, S. Sato, C. Nishijima, K. Takehara, and N. Tonami
Diastolic Dysfunction in Patients with Systemic Sclerosis Detected by Gated Myocardial Perfusion SPECT: An Early Sign of Cardiac Involvement
J. Nucl. Med., February 1, 2001; 42(2): 183 - 188.
[Abstract] [Full Text]

Home page
 Anesth. Analg.Home page
K. G. Lathi, P. R. Vale, D. W. Losordo, R. M. Cespedes, J. F. Symes, D. D. Esakof, M. Maysky, and J. M. Isner
Gene Therapy with Vascular Endothelial Growth Factor for Inoperable Coronary Artery Disease: Anesthetic Management and Results
Anesth. Analg., January 1, 2001; 92(1): 19 - 25.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
J. Narula, M. S. Dawson, B. K. Singh, A. Amanullah, E. R. Acio, F. A. Chaudhry, R. B. Arani, and A. E. Iskandrian
Noninvasive characterization of stunned, hibernating, remodeled and nonviable myocardium in ischemic cardiomyopathy
J. Am. Coll. Cardiol., November 15, 2000; 36(6): 1913 - 1919.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
C. D. L. Bavelaar-Croon, H. W. M. Kayser, E. E. van der Wall, A. de Roos, P. Dibbets-Schneider, E. K. J. Pauwels, G. Germano, and D. E. Atsma
Left Ventricular Function: Correlation of Quantitative Gated SPECT and MR Imaging over a Wide Range of Values
Radiology, November 1, 2000; 217(2): 572 - 575.
[Abstract] [Full Text]

Home page
 CirculationHome page
P. R. Vale, D. W. Losordo, C. E. Milliken, M. Maysky, D. D. Esakof, J. F. Symes, and J. M. Isner
Left Ventricular Electromechanical Mapping to Assess Efficacy of phVEGF165 Gene Transfer for Therapeutic Angiogenesis in Chronic Myocardial Ischemia
Circulation, August 29, 2000; 102(9): 965 - 974.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
R. J. Gibbons, K. Chatterjee, J. Daley, J. S. Douglas, S. D. Fihn, J. M. Gardin, M. A. Grunwald, D. Levy, B. W. Lytle, R. A. O'Rourke, et al.
ACC/AHA/ACP-ASIM guidelines for the management of patients with chronic stable angina: A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee on Management of Patients With Chronic Stable Angina)
J. Am. Coll. Cardiol., June 1, 1999; 33(7): 2092 - 2197.
[Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
E. Tadamura, T. Kudoh, M. Motooka, M. Inubushi, S. Shirakawa, N. Hattori, T. Okada, T. Matsuda, T. Koshiji, K. Nishimura, et al.
Assessment of regional and global left ventricular function by reinjection Tl-201 and rest Tc-99m sestamibi ECG-gated SPECT: Comparison with three-dimensional magnetic resonance imaging
J. Am. Coll. Cardiol., March 15, 1999; 33(4): 991 - 997.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
S. Iskander and A. E. Iskandrian
Risk assessment using single-photon emission computed tomographic technetium-99m sestamibi imaging
J. Am. Coll. Cardiol., July 1, 1998; 32(1): 57 - 62.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
D. W. Losordo, P. R. Vale, R. C. Hendel, C. E. Milliken, F. D. Fortuin, N. Cummings, R. A. Schatz, T. Asahara, J. M. Isner, and R. E. Kuntz
Phase 1/2 Placebo-Controlled, Double-Blind, Dose-Escalating Trial of Myocardial Vascular Endothelial Growth Factor 2 Gene Transfer by Catheter Delivery in Patients With Chronic Myocardial Ischemia
Circulation, April 30, 2002; 105(17): 2012 - 2018.
[Abstract] [Full Text] [PDF]


HOME SUBSCRIPTIONS CURRENT ISSUE PAST ISSUES CARDIOSOURCE SEARCH HELP FEEDBACK
Copyright © 1997 by the American College of Cardiology Foundation.