Cardiac rhythm and conduction in Duchenne's muscular dystrophy: a prospective study of 20 patients
JK Perloff
This study was designed to determine the types and prevalence of rhythm and conduction disturbances in Duchenne's muscular dystrophy, and examine the results in light of known morphologic abnormalities of the myocardium and the small coronary arteries, and in the context of left ventricular function, regional wall motion, mitral valve prolapse and left atrial size. The observed disorders of impulse and conduction extended from the sinus node to the His-Purkinje system. Rhythm disturbances included persistent and labile sinus tachycardia (gradual or abrupt), sinus arrhythmia, sinus pauses, atrial ectopic beats, atrial ectopic rhythm, junctional rhythm, atrial flutter and ventricular premature beats (uniform, multiform, bigeminal and repetitive). Disorders of conduction included abnormal intraatrial or interatrial conduction, Mobitz type I block, nonconducted atrial premature beats, short PR interval, right ventricular conduction delay and rightward axis compatible with left posterior fascicular block. The role of dystrophic involvement of specialized conduction tissues and of the small vessel coronary arteriopathy remains speculative, but mitral valve prolapse, left atrial size and left ventricular size, function and regional wall motion played no discernible part in the genesis of the rhythm and conduction disturbances. Except for end-stage atrial flutter, these disturbances were not clinically deleterious.
This article has been cited by other articles:
|
|
|
|
 
S. M. S. van Westrum, E. M. Hoogerwaard, L. Dekker, T. S. Standaar, E. Bakker, P. F. Ippel, J. C. Oosterwijk, D. F. Majoor-Krakauer, A. J. van Essen, N. J. Leschot, et al.
Cardiac abnormalities in a follow-up study on carriers of Duchenne and Becker muscular dystrophy
Neurology,
July 5, 2011;
77(1):
62 - 66.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Albesa, J. Ogrodnik, J.-S. Rougier, and H. Abriel
Regulation of the cardiac sodium channel Nav1.5 by utrophin in dystrophin-deficient mice
Cardiovasc Res,
February 1, 2011;
89(2):
320 - 328.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Bostick, Y. Yue, C. Long, and D. Duan
Prevention of Dystrophin-Deficient Cardiomyopathy in Twenty-One-Month-Old Carrier Mice by Mosaic Dystrophin Expression or Complementary Dystrophin/Utrophin Expression
Circ. Res.,
January 4, 2008;
102(1):
121 - 130.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Gavillet, J.-S. Rougier, A. A. Domenighetti, R. Behar, C. Boixel, P. Ruchat, H.-A. Lehr, T. Pedrazzini, and H. Abriel
Cardiac Sodium Channel Nav1.5 Is Regulated by a Multiprotein Complex Composed of Syntrophins and Dystrophin
Circ. Res.,
August 18, 2006;
99(4):
407 - 414.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. L. Jefferies, B. W. Eidem, J. W. Belmont, W. J. Craigen, S. M. Ware, S. D. Fernbach, S. R. Neish, E. O. Smith, and J. A. Towbin
Genetic Predictors and Remodeling of Dilated Cardiomyopathy in Muscular Dystrophy
Circulation,
November 1, 2005;
112(18):
2799 - 2804.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Muntoni
Cardiac Complications of Childhood Myopathies
J Child Neurol,
March 1, 2003;
18(3):
191 - 202.
[Abstract]
[PDF]
|
|
|
|
|
|
|
R. J. Sarma, C. A. Stewart, I. S. Gilgoff, and J. R. Bach
Cardiovascular Considerations in the Management of Duchenne Muscular Dystrophy
Neurorehabil Neural Repair,
January 1, 1992;
6(2):
113 - 119.
[Abstract]
[PDF]
|
|
|
|
|
|
|
J. F. Gaffney, W. J. Kingston, L. A. Metlay, and R. Gramiak
Left Ventricular Thrombus and Systemic Emboli Complicating the Cardiomyopathy of Duchenne's Muscular Dystrophy
Arch Neurol,
November 1, 1989;
46(11):
1249 - 1252.
[Abstract]
[PDF]
|
|
|
|
