|
| HOME | SUBSCRIPTIONS | CURRENT ISSUE | PAST ISSUES | CARDIOSOURCE | SEARCH | HELP | FEEDBACK |
|
|
|
|||||||||
|
|||||||||||
|
J Am Coll Cardiol, 1997; 29:651-658 © 1997 by the American College of Cardiology Foundation |
Cooperative Studies Program of the Medical Research Service of the Department of Veterans Affairs, Washington, D.C., USA. gottdien@ziplink.net
OBJECTIVES: We sought to determine the relations of left atrial (LA) size to blood pressure, obesity, race, age and left ventricular (LV) mass in hypertension. BACKGROUND: Although obesity, race and age may influence LV mass, their effects on LA size have not been defined in hypertension. METHODS: Left atrial size was measured in 690 men (58% African-Americans) with mild to moderate hypertension (mean [+/-SD] blood pressure 152 +/- 15/98 +/- 6 mm Hg) and a high prevalence of LV hypertrophy. Effects of LV mass, adiposity, race, age, physical activity, height, weight, sodium excretion, plasma renin activity and heart rate were examined. RESULTS: Left atrial size was greater (p < or = 0.0001) in obese (44.2 +/- 5.7 mm) than in overweight (41.6 +/- 5.9 mm) or normal weight (38.9 +/- 6.2 mm) patients. Left atrial enlargement (> or = 43 mm) was present in 56% of obese patients compared with 42% of overweight and 25% of normal weight hypertensive men. As age increased, white patients had a greater LA size than African-American patients. Although there was no relation between LV mass and LA size in normal weight patients, there was a significant positive relation in obese patients. On multiple regression analysis, obesity was the strongest independent predictor of increased LA size. CONCLUSIONS: Obesity is the strongest predictor of LA size in patients with hypertension and amplifies the relation between LA size and LV mass. Race influences effects of age and hypertension on LA size. Because increased LA size and LV mass (also influenced by obesity) are associated with an adverse outcome, these findings underscore the importance of obesity, race and age with regard to the cardiac effects of hypertension.
This article has been cited by other articles:
|
|
 |
|
  C. A. Garza, P. A. Pellikka, V. K. Somers, M. G. Sarr, J. B. Seward, M. L. Collazo-Clavell, E. Oehler, and F. Lopez-Jimenez Major weight loss prevents long-term left atrial enlargement in patients with morbid and extreme obesity Eur J Echocardiogr, September 1, 2008; 9(5): 587 - 593. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. S. Maurer, D. Burkhoff, L. P. Fried, J. Gottdiener, D. L. King, and D. W. Kitzman Ventricular Structure and Function in Hypertensive Participants With Heart Failure and a Normal Ejection Fraction: The Cardiovascular Health Study J. Am. Coll. Cardiol., March 6, 2007; 49(9): 972 - 981. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. N. Nicolaou, J. E. Papadakis, E. N. Karatzis, S. I. Dermitzaki, A. K. Tsakiris, and P. D. Skoufas Impact of the Metabolic Syndrome on Atrial Size in Patients With New-Onset Atrial Fibrillation Angiology, February 1, 2007; 58(1): 21 - 25. [Abstract] [PDF]
|
|
|
|
 |
|
 E. Gerdts, K. Wachtell, P. Omvik, J. E. Otterstad, L. Oikarinen, K. Boman, B. Dahlof, and R. B. Devereux Left Atrial Size and Risk of Major Cardiovascular Events During Antihypertensive Treatment: Losartan Intervention for Endpoint Reduction in Hypertension Trial Hypertension, February 1, 2007; 49(2): 311 - 316. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Coromilas Obesity and Atrial Fibrillation: Is One Epidemic Feeding the Other? JAMA, November 24, 2004; 292(20): 2519 - 2520. [Full Text] [PDF]
|
|
|
|
|
|
J Kawai, K Tanabe, C.-L Wang, T Tani, T Yagi, H Shiotani, and S Morioka Comparison of left atrial size by freehand scanning three-dimensional echocardiography and two-dimensional echocardiography Eur J Echocardiogr, January 1, 2004; 5(1): 18 - 24. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R S Vasan Cardiac function and obesity Heart, October 1, 2003; 89(10): 1127 - 1129. [Full Text] [PDF]
|
|
|
|
|
|
A. M. Pritchett, S. J. Jacobsen, D. W. Mahoney, R. J. Rodeheffer, K. R. Bailey, and M. M. Redfield Left atrial volume as an index ofleft atrial size: a population-based study J. Am. Coll. Cardiol., March 19, 2003; 41(6): 1036 - 1043. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. K. Rutter, H. Parise, E. J. Benjamin, D. Levy, M. G. Larson, J. B. Meigs, R. W. Nesto, P. W.F. Wilson, and R. S. Vasan Impact of Glucose Intolerance and Insulin Resistance on Cardiac Structure and Function: Sex-Related Differences in the Framingham Heart Study Circulation, January 28, 2003; 107(3): 448 - 454. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Gerdts, L. Oikarinen, V. Palmieri, J. E. Otterstad, K. Wachtell, K. Boman, B. Dahlof, and R. B. Devereux Correlates of Left Atrial Size in Hypertensive Patients With Left Ventricular Hypertrophy: The Losartan Intervention For Endpoint Reduction in Hypertension (LIFE) Study Hypertension, March 1, 2002; 39(3): 739 - 743. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. K. Jha, M. G. Shlipak, W. Hosmer, C. D. Frances, and W. S. Browner Racial Differences in Mortality Among Men Hospitalized in the Veterans Affairs Health Care System JAMA, January 17, 2001; 285(3): 297 - 303. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. S. Gottdiener, D. J. Reda, D. W. Williams, B. J. Materson, W. Cushman, and R. J. Anderson Effect of Single-Drug Therapy on Reduction of Left Atrial Size in Mild to Moderate Hypertension : Comparison of Six Antihypertensive Agents Circulation, July 14, 1998; 98(2): 140 - 148. [Abstract] [Full Text] [PDF]
|
|
| HOME | SUBSCRIPTIONS | CURRENT ISSUE | PAST ISSUES | CARDIOSOURCE | SEARCH | HELP | FEEDBACK |
