Advertisement






Click here for more guidelines.
CME Topic Collections Past Issues Search Current Issue Home
     

J Am Coll Cardiol, 1997; 29:486-490
© 1997 by the American College of Cardiology Foundation
This Article
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Amant, C
Right arrow Articles by Bertrand, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Amant, C
Right arrow Articles by Bertrand, M.

The angiotensin II type 1 receptor gene polymorphism is associated with coronary artery vasoconstriction

C Amant, M Hamon, C Bauters, F Richard, N Helbecque, EP McFadden, X Escudero, JM Lablanche, P Amouyel, and ME Bertrand

CJF INSERM 95-05, Institut Pasteur de Lille, France.

OBJECTIVES: This study sought to assess the potential association of the angiotensin-converting enzyme (ACE) and angiotensin II type 1 (AT1) receptor gene polymorphisms on coronary vasomotion in humans. BACKGROUND: Abnormal coronary vasomotion plays a role in the clinical expression of coronary atherosclerosis. The components of the renin-angiotensin system are important determinants of vasomotor tone. Furthermore, epidemiologic evidence suggests that these components are involved in the pathogenesis of coronary artery disease. Indeed, two genetic polymorphisms of the ACE and AT1 receptor genes were synergistically associated with the occurrence of myocardial infarction. The influence of these genetic polymorphisms on the risk of myocardial infarction may be related, at least in part, to a deleterious effect on coronary vasomotion. METHODS: We studied the response of angiographically normal human coronary arteries after intravenous injection of methylergonovine maleate, a potent vasoconstrictor whose effects have been previously explored in various aspects of coronary artery disease. We characterized the ACE and AT1 receptor genotypes in a consecutive series of 140 patients with normal coronary arteries. Coronary vasomotion was assessed with quantitative coronary angiography. RESULTS: No effect of the ACE gene polymorphism was detected. Conversely, the patients carrying the AT1 receptor CC genotype (n = 13) had significantly greater vasoconstriction in distal coronary vessels (p < 0.009). CONCLUSIONS: The AT1 receptor gene polymorphism is associated with coronary vasomotion in humans.


This article has been cited by other articles:


Home page
In VivoHome page
A. GLUBA, M. BANACH, D. P. MIKHAILIDIS, and J. RYSZ
Genetic Determinants of Cardiovascular Disease: The Renin-Angiotensin-Aldosterone System, Paraoxonases, Endothelin-1, Nitric Oxide Synthase and Adrenergic Receptors
In Vivo, September 1, 2009; 23(5): 797 - 812.
[Abstract] [Full Text] [PDF]


Home page
Journal of Renin-Angiotensin-Aldosterone SystemHome page
S. A. Alves Correa, S. M. Ribeiro de Noronha, N. C. Nogueira-de-Souza, C. Valleta de Carvalho, A. M. Massad Costa, J. Juvenal Linhares, M. T. Vieira Gomes, and I. D. C. Guerreiro da Silva
Association between the angiotensin-converting enzyme (insertion/deletion) and angiotensin II type 1 receptor (A1166C) polymorphisms and breast cancer among Brazilian women
Journal of Renin-Angiotensin-Aldosterone System, March 1, 2009; 10(1): 51 - 58.
[Abstract] [PDF]


Home page
J. Biol. Chem.Home page
M. M. Martin, J. A. Buckenberger, J. Jiang, G. E. Malana, G. J. Nuovo, M. Chotani, D. S. Feldman, T. D. Schmittgen, and T. S. Elton
The Human Angiotensin II Type 1 Receptor +1166 A/C Polymorphism Attenuates MicroRNA-155 Binding
J. Biol. Chem., August 17, 2007; 282(33): 24262 - 24269.
[Abstract] [Full Text] [PDF]


Home page
HypertensionHome page
V. A. Cameron, T. J. Mocatta, A. P. Pilbrow, C. M. Frampton, R. W. Troughton, A. M. Richards, and C. C. Winterbourn
Angiotensin Type-1 Receptor A1166C Gene Polymorphism Correlates With Oxidative Stress Levels in Human Heart Failure
Hypertension, June 1, 2006; 47(6): 1155 - 1161.
[Abstract] [Full Text] [PDF]


Home page
J. Am. Soc. Nephrol.Home page
C. C.-c. Hsu, M. S. Bray, W.H.L. Kao, J. S. Pankow, E. Boerwinkle, and J. Coresh
Genetic Variation of the Renin-Angiotensin System and Chronic Kidney Disease Progression in Black Individuals in the Atherosclerosis Risk in Communities Study
J. Am. Soc. Nephrol., February 1, 2006; 17(2): 504 - 512.
[Abstract] [Full Text] [PDF]


Home page
Physiol. Rev.Home page
P. Meneton, X. Jeunemaitre, H. E. de Wardener, and G. A. Macgregor
Links Between Dietary Salt Intake, Renal Salt Handling, Blood Pressure, and Cardiovascular Diseases
Physiol Rev, April 1, 2005; 85(2): 679 - 715.
[Abstract] [Full Text] [PDF]


Home page
Eur Heart JHome page
Y. Murase, Y. Yamada, A. Hirashiki, S. Ichihara, H. Kanda, M. Watarai, F. Takatsu, T. Murohara, and M. Yokota
Genetic risk and gene-environment interaction in coronary artery spasm in Japanese men and women
Eur. Heart J., June 1, 2004; 25(11): 970 - 977.
[Abstract] [Full Text] [PDF]


Home page
Mol. Pharmacol.Home page
J. L. Hansen, S. Haunso, M. R. Brann, S. P. Sheikh, and D. M. Weiner
Loss-of-Function Polymorphic Variants of the Human Angiotensin II Type 1 Receptor
Mol. Pharmacol., March 1, 2004; 65(3): 770 - 777.
[Abstract] [Full Text] [PDF]


Home page
Journal of Renin-Angiotensin-Aldosterone SystemHome page
J.-J. Mourad, G. Ducailar, A. Rudnicki, M. Lajemi, A. Mimran, and M. E Safar
Age-related increase of pulse pressure and gene polymorphisms in essential hypertension: a preliminary study
Journal of Renin-Angiotensin-Aldosterone System, June 1, 2002; 3(2): 109 - 115.
[Abstract] [PDF]


Home page
HeartHome page
J R Ortlepp, H P Vosberg, S Reith, F Ohme, N G Mahon, D Schroder, H G Klues, P Hanrath, and W J McKenna
Genetic polymorphisms in the renin-angiotensin-aldosterone system associated with expression of left ventricular hypertrophy in hypertrophic cardiomyopathy: a study of five polymorphic genes in a family with a disease causing mutation in the myosin binding protein C gene
Heart, March 1, 2002; 87(3): 270 - 275.
[Abstract] [Full Text] [PDF]


Home page
JRSMHome page
B Chandrasekaran and A S Kurbaan
Myocardial infarction with angiographically normal coronary arteries
J R Soc Med, January 8, 2002; 95(8): 398 - 400.
[Full Text] [PDF]


Home page
Eur Heart JHome page
A Meirhaeghe, C Bauters, N Helbecque, M Hamon, E McFadden, J.-M Lablanche, M Bertrand, and P Amouyel
The human G-protein {beta}3 subunit C825T polymorphism is associated with coronary artery vasoconstriction
Eur. Heart J., May 2, 2001; 22(10): 845 - 848.
[Abstract] [PDF]


Home page
HeartHome page
P P van Geel, Y M Pinto, A H Zwinderman, R H Henning, A J van Boven, J W Jukema, A V G Bruschke, J J P Kastelein, W H van Gilst, and G F BAXTER
Increased risk for ischaemic events is related to combined RAS polymorphism
Heart, April 1, 2001; 85(4): 458 - 462.
[Abstract] [Full Text]


Home page
J Am Coll CardiolHome page
R. E. Schmieder, J. Erdmann, C. Delles, J. Jacobi, E. Fleck, K. Hilgers, and V. Regitz-Zagrosek
Effect of the angiotensin II type 2-receptor gene (+1675 G/A) on left ventricular structure in humans
J. Am. Coll. Cardiol., January 1, 2001; 37(1): 175 - 182.
[Abstract] [Full Text] [PDF]


Home page
J Am Coll CardiolHome page
A. Prasad, S. Narayanan, M. A. Waclawiw, N. Epstein, and A. A. Quyyumi
The insertion/deletion polymorphism of the angiotensin-converting enzyme gene determines coronary vascular tone and nitric oxide activity
J. Am. Coll. Cardiol., November 1, 2000; 36(5): 1579 - 1586.
[Abstract] [Full Text] [PDF]


Home page
HypertensionHome page
A. S. Wierzbicki, M. Lambert-Hammill, P. J. Lumb, and M. A. Crook
Renin-Angiotensin System Polymorphisms and Coronary Events in Familial Hypercholesterolemia
Hypertension, November 1, 2000; 36(5): 808 - 812.
[Abstract] [Full Text] [PDF]


Home page
Pharmacol. Rev.Home page
M. de Gasparo, K. J. Catt, T. Inagami, J. W. Wright, and Th. Unger
International Union of Pharmacology. XXIII. The Angiotensin II Receptors
Pharmacol. Rev., September 1, 2000; 52(3): 415 - 472.
[Abstract] [Full Text] [PDF]


Home page
HypertensionHome page
W. Spiering, A. A. Kroon, M. M. J. J. Fuss-Lejeune, M. J. A. P. Daemen, and P. W. de Leeuw
Angiotensin II Sensitivity Is Associated With the Angiotensin II Type 1 Receptor A1166C Polymorphism in Essential Hypertensives on a High Sodium Diet
Hypertension, September 1, 2000; 36(3): 411 - 416.
[Abstract] [Full Text] [PDF]


Home page
HypertensionHome page
P. P. van Geel, Y. M. Pinto, A. A. Voors, H. Buikema, M. Oosterga, H. J. G. M. Crijns, and W. H. van Gilst
Angiotensin II Type 1 Receptor A1166C Gene Polymorphism Is Associated With an Increased Response to Angiotensin II in Human Arteries
Hypertension, March 1, 2000; 35(3): 717 - 721.
[Abstract] [Full Text] [PDF]


Home page
Eur J Heart FailHome page
B. Andersson, I. Blange, and C. Sylven
Angiotensin-II type 1 receptor gene polymorphism and long-term survival in patients with idiopathic congestive heart failure
Eur J Heart Fail, December 17, 1999; 1(4): 363 - 369.
[Abstract] [Full Text] [PDF]


Home page
CirculationHome page
K. F. Hilgers, M. R. W. Langenfeld, M. Schlaich, R. Veelken, and R. E. Schmieder
1166 A/C Polymorphism of the Angiotensin II Type 1 Receptor Gene and the Response to Short-Term Infusion of Angiotensin II
Circulation, September 28, 1999; 100(13): 1394 - 1399.
[Abstract] [Full Text] [PDF]


Home page
Cardiovasc ResHome page
A. Anvari, Z. Turel, A. Schmidt, N. Yilmaz, G. Mayer, K. Huber, E. Schuster, and M. Gottsauner-Wolf
Angiotensin-converting enzyme and angiotensin II receptor 1 polymorphism in coronary disease and malignant ventricular arrhythmias
Cardiovasc Res, September 1, 1999; 43(4): 879 - 883.
[Abstract] [Full Text] [PDF]


Home page
J Am Coll CardiolHome page
H. Murakami, K. Urabe, and M. Nishimura
Inappropriate microvascular constriction produced transient ST-segment elevation in patients with syndrome X
J. Am. Coll. Cardiol., November 1, 1998; 32(5): 1287 - 1294.
[Abstract] [Full Text] [PDF]


Home page
HypertensionHome page
A. P. R. M. Osterop, M. J. M. Kofflard, L. A. Sandkuijl, F. J. t. Cate, R. Krams, M. A. D. H. Schalekamp, and A. H. J. Danser
AT1 Receptor A/C1166 Polymorphism Contributes to Cardiac Hypertrophy in Subjects With Hypertrophic Cardiomyopathy
Hypertension, November 1, 1998; 32(5): 825 - 830.
[Abstract] [Full Text] [PDF]



 
  CME Topic Collections Past Issues Search Current Issue Home

Advertisement