|
|
||||||||||
|
J Am Coll Cardiol, 1996; 27:690-695 © 1996 by the American College of Cardiology Foundation |
Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri, USA.
OBJECTIVES: This study sought to determine whether the clinical and electrophysiologic criteria developed in adults also identify children with Wolff-Parkinson-White syndrome at risk for sudden death. BACKGROUND: In adults with Wolff-Parkinson-White syndrome, a shortest RR interval <220 ms during atrial fibrillation is a sensitive marker for sudden death. However, because reliance on the shortest RR interval has a low positive predictive value, the clinical history has assumed a pivotal role in assessing risk. This approach has not been evaluated in children. METHODS: We retrospectively evaluated 60 children = 18 years old who underwent comprehensive electrophysiologic evaluation between 1979 and 1989 before undergoing operation for Wolff-Parkinson-White syndrome. Clinical and electrophysiologic data were analyzed after patients had been grouped by their clinical presentation: high risk (cardiac arrest), intermediate risk (syncope or atrial fibrillation) or low risk (orthodromic reciprocating tachycardia alone). RESULTS: Ten children had a clinical cardiac arrest (high risk); only one had a prior history of syncope or atrial fibrillation. Compared with the intermediate (n = 19) and low risk groups (n = 31), there were no differences in age ([mean +/- SD] 14.8 +/- 0.6 vs. 14.7 +/- 0.6 vs. 14.5 +/- 1.7 years), duration of symptoms (1.9 +/- 0.5 vs. 4.1 +/- 1.1 vs. 5.2 +/- .08 years), incidence of congenital heart disease (30% vs 26% vs 32%), presence of multiple pathways (20% vs 16% vs 16%) or accessory pathway location. A shortest pre-excited RR interval <220 ms was found in 7 of 7 high risk patients (sensitivity 100%), 14 of 19 intermediate risk patients and 11 of 31 low risk patients (prevalence 35%). CONCLUSIONS: Cardiac arrest was the only distinguishing clinical feature between high and low risk groups and the first manifestation in 80% of the children of an accessory pathway that can precipitate a life-threatening arrhythmia. In this series, the largest reported to date of children with Wolff-Parkinson-White syndrome having a cardiac arrest, a shortest pre-excited RR interval <220 ms was more sensitive than clinical history for identifying those at risk for sudden death.
This article has been cited by other articles:
![]() |
B. Brembilla-Perrot, F. Chometon, L. Groben, S. Ammar, J. Bertrand, C. Marcha, J.L. Cloez, A. Tisserand, O. Huttin, C. Tatar, et al. Interest of non-invasive and semi-invasive testings in asymptomatic children with pre-excitation syndrome Europace, September 1, 2007; 9(9): 837 - 843. [Abstract] [Full Text] [PDF] |
||||
![]() |
H. J. Wellens, C. Pappone, V. Santinelli, H. J. Wellens, C. Pappone, and V. Santinelli When to Perform Catheter Ablation in Asymptomatic Patients With a Wolff-Parkinson-White Electrocardiogram Circulation, October 4, 2005; 112(14): 2201 - 2216. [Full Text] [PDF] |
||||
![]() |
C. Pappone, F. Manguso, R. Santinelli, G. Vicedomini, S. Sala, G. Paglino, P. Mazzone, C. C. Lang, S. Gulletta, G. Augello, et al. Radiofrequency Ablation in Children with Asymptomatic Wolff-Parkinson-White Syndrome N. Engl. J. Med., September 16, 2004; 351(12): 1197 - 1205. [Abstract] [Full Text] [PDF] |
||||
![]() |
E. F. D. Wever and E. O. Robles de Medina Sudden death in patients without structural heart disease J. Am. Coll. Cardiol., April 7, 2004; 43(7): 1137 - 1144. [Abstract] [Full Text] [PDF] |
||||
![]() |
R. M. Campbell, M. J. Strieper, P. A. Frias, K. K. Collins, G. F. Van Hare, and A. M. Dubin Survey of Current Practice of Pediatric Electrophysiologists for Asymptomatic Wolff-Parkinson-White Syndrome Pediatrics, March 1, 2003; 111(3): e245 - 247. [Abstract] [Full Text] [PDF] |
||||
![]() |
D. J. Heaven, J. A. Till, and S. Y. Ho Sudden death in a child with an unusual accessory connection Europace, January 1, 2000; 2(3): 224 - 227. [Abstract] [PDF] |
||||
![]() |
D. P. Zipes and H. J. J. Wellens Sudden Cardiac Death Circulation, November 24, 1998; 98(21): 2334 - 2351. [Full Text] [PDF] |
||||
| HOME | SUBSCRIPTIONS | CURRENT ISSUE | PAST ISSUES | CARDIOSOURCE | SEARCH | HELP | FEEDBACK |