Does ischemic preconditioning occur in patients?
RA Kloner
and
D Yellon
Heart Institute Research Laboratory, Hospital of the Good Samaritan, University of Southern California, Los Angeles 90017.
Ischemic preconditioning offers powerful protection from ischemic necrosis in a wide range of animal species, but does it occur in humans? Support for preconditioning in humans comes from several sources: studies showing increased tolerance to repetitive balloon inflations during angioplasty, some (but not all) studies suggesting that preinfarction angina confers an early beneficial effect, studies showing that patients can develop sudden tolerance to repetitive exercise- or pacing-induced ischemia, cardiothoracic studies of intermittent aortic cross-clamping showing better preservation of myocardial adenosine triphosphate and in vitro studies of isolated human trabecular muscle and isolated human ventricular myocytes that demonstrate a biology consistent with preconditioning. In the future, preconditioning or "preconditioning mimetic" agents have the potential to be applied to a wide array of cardiovascular disorders and might result in better preservation of the heart in instances of cardiopulmonary bypass, heart transplantation, angina and myocardial infarction.
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3(2008):
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|
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48(1):
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|
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Letter Regarding Article by Staat et al, "Postconditioning the Human Heart"
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March 28, 2006;
113(12):
e665 - e665.
[Full Text]
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|
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|

|
 |

|
 |
 
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May 1, 2005;
66(2):
233 - 244.
[Abstract]
[Full Text]
[PDF]
|
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|

|
 |

|
 |
 
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Benefit of an exercise program before myocardial infarction
J. Am. Coll. Cardiol.,
March 15, 2005;
45(6):
939 - 940.
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
S. Vogt, I. Portig, B. Kusch, S. Pankuweit, A. S. Sirat, D. Troitzsch, B. Maisch, and R. Moosdorf
Detection of anti-hsp70 immunoglobulin G antibodies indicates better outcome in coronary artery bypass grafting patients suffering from severe preoperative angina
Ann. Thorac. Surg.,
September 1, 2004;
78(3):
883 - 889.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
W. K. Laskey and D. Beach
Frequency and clinical significance of ischemic preconditioning during percutaneous coronary intervention
J. Am. Coll. Cardiol.,
September 17, 2003;
42(6):
998 - 1003.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
J. F. Huizar, L. A. Gonzalez, J. Alderman, and H. S. Smith
Sulfonylureas attenuate electrocardiographic ST-segment elevation during an acute myocardial infarction in diabetics
J. Am. Coll. Cardiol.,
September 17, 2003;
42(6):
1017 - 1021.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
Y Birnbaum and B J Drew
The electrocardiogram in ST elevation acute myocardial infarction: correlation with coronary anatomy and prognosis
Postgrad. Med. J.,
September 1, 2003;
79(935):
490 - 504.
[Abstract]
[Full Text]
|
 |
|

|
 |

|
 |
 
M. C. Riddle
Sulfonylureas Differ in Effects on Ischemic Preconditioning--Is it Time to Retire Glyburide?
J. Clin. Endocrinol. Metab.,
February 1, 2003;
88(2):
528 - 530.
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
J. Vinten-Johansen, Z.-Q. Zhao, and R. A. Guyton
Cardiac Surgical Physiology
Card. Surg. Adult,
January 1, 2003;
2(2003):
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|
 |
|

|
 |

|
 |
 
R. Scognamiglio, A. Avogaro, S. Vigili de Kreutzenberg, C. Negut, M. Palisi, E. Bagolin, and A. Tiengo
Effects of Treatment With Sulfonylurea Drugs or Insulin on Ischemia-Induced Myocardial Dysfunction in Type 2 Diabetes
Diabetes,
March 1, 2002;
51(3):
808 - 812.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
R. A. Kloner and R. B. Jennings
Consequences of Brief Ischemia: Stunning, Preconditioning, and Their Clinical Implications: Part 2
Circulation,
December 18, 2001;
104(25):
3158 - 3167.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
K. Nandagopal, T. M. Dawson, and V. L. Dawson
Critical Role for Nitric Oxide Signaling in Cardiac and Neuronal Ischemic Preconditioning and Tolerance
J. Pharmacol. Exp. Ther.,
April 12, 2001;
297(2):
474 - 478.
[Abstract]
[Full Text]
|
 |
|

|
 |

|
 |
 
T. Sato, N. Sasaki, B. O'Rourke, and E. Marban
Adenosine Primes the Opening of Mitochondrial ATP-Sensitive Potassium Channels : A Key Step in Ischemic Preconditioning?
Circulation,
August 15, 2000;
102(7):
800 - 805.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
T. Sato, N. Sasaki, B. O'Rourke, and E. Marban
Nicorandil, a potent cardioprotective agent, acts by opening mitochondrial ATP-dependent potassium channels
J. Am. Coll. Cardiol.,
February 1, 2000;
35(2):
514 - 518.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
D Karila-Cohen, D Czitrom, E Brochet, M Faraggi, P Seknadji, D Himbert, J.-M Juliard, P Assayag, and P.G Steg
Decreased no-reflow in patients with anterior myocardial infarction and pre-infarction angina
Eur. Heart J.,
December 1, 1999;
20(23):
1724 - 1730.
[Abstract]
[PDF]
|
 |
|

|
 |

|
 |
 
C.-H. Chen, M. O. Gray, and D. Mochly-Rosen
Cardioprotection from ischemia by a brief exposure to physiological levels of ethanol: Role of epsilon protein kinase C
PNAS,
October 26, 1999;
96(22):
12784 - 12789.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
G. W. Dorn II, M. C. Souroujon, T. Liron, C.-H. Chen, M. O. Gray, H. Z. Zhou, M. Csukai, G. Wu, J. N. Lorenz, and D. Mochly-Rosen
Sustained in vivo cardiac protection by a rationally designed peptide that causes varepsilon protein kinase C translocation
PNAS,
October 26, 1999;
96(22):
12798 - 12803.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
M. A. Leesar, M. F. Stoddard, S. Manchikalapudi, and R. Bolli
Bradykinin-induced preconditioning in patients undergoing coronary angioplasty
J. Am. Coll. Cardiol.,
September 1, 1999;
34(3):
639 - 650.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
W. K. Laskey
Beneficial Impact of Preconditioning During PTCA on Creatine Kinase Release
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April 27, 1999;
99(16):
2085 - 2089.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
M. Billinger, M. Fleisch, F. R. Eberli, A. Garachemani, B. Meier, and C. Seiler
Is the development of myocardial tolerance to repeated ischemia in humans due to preconditioning or to collateral recruitment?
J. Am. Coll. Cardiol.,
March 15, 1999;
33(4):
1027 - 1035.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
H. Klepzig, G. Kober, C. Matter, H. Luus, H. Schneider, K.H. Boedeker, W. Kiowski, F.W. Amann, D. Gruber, S. Harris, et al.
Sulfonylureas and ischaemic preconditioning; a double-blind, placebo-controlled evaluation of glimepiride and glibenclamide
Eur. Heart J.,
March 2, 1999;
20(6):
439 - 446.
[Abstract]
[PDF]
|
 |
|

|
 |

|
 |
 
K.F. Fox, M.R. Cowie, D.A. Wood, A.J.S. Coats, P.A. Poole-Wilson, and G.C. Sutton
New perspectives on heart failure due to myocardial ischaemia
Eur. Heart J.,
February 2, 1999;
20(4):
256 - 262.
[PDF]
|
 |
|

|
 |

|
 |
 
R. H. Christenson and H. M. E. Azzazy
Biochemical markers of the acute coronary syndromes
Clin. Chem.,
August 1, 1998;
44(8):
1855 - 1864.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
R. A. Kloner, R. Bolli, E. Marban, L. Reinlib, and E. Braunwald
Medical and Cellular Implications of Stunning, Hibernation, and Preconditioning : An NHLBI Workshop
Circulation,
May 19, 1998;
97(18):
1848 - 1867.
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
R. A. Kloner, T. Shook, E. M. Antman, C. P. Cannon, K. Przyklenk, K. Yoo, C. H. McCabe, and E. Braunwald
Prospective Temporal Analysis of the Onset of Preinfarction Angina Versus Outcome : An Ancillary Study in TIMI-9B
Circulation,
March 24, 1998;
97(11):
1042 - 1045.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
E. R. Schwarz, J. Fleischhauer, H. Montino, R. Chakupurakal, M. Foresti, T. Schuetz, S. Sack, M. Mohri, M. Arras, W. Schaper, et al.
Infarct Size Reduction by Ischemic Preconditioning is a Monophasic, Short-Lived Phenomenon in Anesthetized Pigs
Journal of Cardiovascular Pharmacology and Therapeutics,
January 1, 1998;
3(1):
63 - 70.
[Abstract]
[PDF]
|
 |
|

|
 |

|
 |
 
Y. Birnbaum, S. L. Hale, and R. A. Kloner
Ischemic Preconditioning at a Distance : Reduction of Myocardial Infarct Size by Partial Reduction of Blood Supply Combined With Rapid Stimulation of the Gastrocnemius Muscle in the Rabbit
Circulation,
September 2, 1997;
96(5):
1641 - 1646.
[Abstract]
[Full Text]
|
 |
|

|
 |

|
 |
 
R. A. Kloner and G. Kay
EDITORIAL: INTRAVENOUS CO-INFUSION OF ADENOSINE AND NOREPINEPHRINE
J. Thorac. Cardiovasc. Surg.,
August 1, 1997;
114(2):
234 - 235.
[Full Text]
|
 |
|

|
 |

|
 |
 
M. Tani, Y. Suganuma, H. Hasegawa, K. Shinmura, Y. Hayashi, X.-d. Guo, and Y. Nakamura
Changes in Ischemic Tolerance and Effects of Ischemic Preconditioning in Middle-aged Rat Hearts
Circulation,
June 3, 1997;
95(11):
2559 - 2566.
[Abstract]
[Full Text]
|
 |
|

|
 |

|
 |
 
P. K. Kaukoranta, M. P. K. Lepojarvi, K. V. Ylitalo, K. T. Kiviluoma, and K. J. Peuhkurinen
Normothermic Retrograde Blood Cardioplegia With or Without Preceding Ischemic Preconditioning
Ann. Thorac. Surg.,
May 1, 1997;
63(5):
1268 - 1274.
[Abstract]
[Full Text]
|
 |
|

|
 |

|
 |
 
S. J. Kapadia, J. S. Terlato, and A. S. Most
Presence of a Critical Coronary Artery Stenosis Does Not Abolish the Protective Effect of Ischemic Preconditioning
Circulation,
March 4, 1997;
95(5):
1286 - 1292.
[Abstract]
[Full Text]
|
 |
|

|
 |

|
 |
 
B. C.G. Gho, R. G. Schoemaker, M. A. van den Doel, D. J. Duncker, and P. D. Verdouw
Myocardial Protection by Brief Ischemia in Noncardiac Tissue
Circulation,
November 1, 1996;
94(9):
2193 - 2200.
[Abstract]
[Full Text]
|
 |
|

|
 |

|
 |
 
V. Pasceri, G. A. Lanza, G. Patti, P. Pedrotti, F. Crea, and A. Maseri
Preconditioning by Transient Myocardial Ischemia Confers Protection Against Ischemia-Induced Ventricular Arrhythmias in Variant Angina
Circulation,
October 15, 1996;
94(8):
1850 - 1856.
[Abstract]
[Full Text]
|
 |
|

|
 |

|
 |
 
Y. Birnbaum, K. Przyklenk, and R. A. Kloner
Time Frame of Ischemic Preconditioning: Is It Clinically Relevant?
Journal of Cardiovascular Pharmacology and Therapeutics,
October 1, 1996;
1(4):
339 - 346.
[PDF]
|
 |
|

|
 |

|
 |
 
A. K. Ganjoo and W. D. Johnson
Cardioprotective effects of ischemic preconditioning
J. Thorac. Cardiovasc. Surg.,
July 1, 1996;
112(1):
208 - 208.
[Full Text]
|
 |
|

|
 |

|
 |
 
P. G. Burns, I. B. Krukenkamp, C. A. Caldarone, R. J. Kirvaitis, G. R. Gaudette, and S. Levitsky
Is the Preconditioning Response Conserved in Senescent Myocardium?
Ann. Thorac. Surg.,
March 1, 1996;
61(3):
925 - 929.
[Abstract]
[Full Text]
|
 |
|

|
 |

|
 |
 
K. Hu, D. Duan, G.-R. Li, and S. Nattel
Protein Kinase C Activates ATP-Sensitive K+ Current in Human and Rabbit Ventricular Myocytes
Circ. Res.,
March 1, 1996;
78(3):
492 - 498.
[Abstract]
[Full Text]
|
 |
|

|
 |

|
 |
 
F. Andreotti, V. Pasceri, D. R. Hackett, G. J. Davies, A. W. Haider, and A. Maseri
Preinfarction Angina as a Predictor of More Rapid Coronary Thrombolysis in Patients with Acute Myocardial Infarction
N. Engl. J. Med.,
January 4, 1996;
334(1):
7 - 12.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
P. G. Burns, I. B. Krukenkamp, C. A. Caldarone, G. R. Gaudette, E. A. Bukhari, and S. Levitsky
Does Cardiopulmonary Bypass Alone Elicit Myoprotective Preconditioning?
Circulation,
November 1, 1995;
92(9):
447 - 451.
[Abstract]
[Full Text]
|
 |
|

|
 |

|
 |
 
D. K. Arrell, I. Neverova, H. Fraser, E. Marban, and J. E. Van Eyk
Proteomic Analysis of Pharmacologically Preconditioned Cardiomyocytes Reveals Novel Phosphorylation of Myosin Light Chain 1
Circ. Res.,
September 14, 2001;
89(6):
480 - 487.
[Abstract]
[Full Text]
[PDF]
|
 |
|
|