Two-dimensional mitral flow velocity profiles in pig models using epicardial Doppler echocardiography

Department of Thoracic and Cardiovascular Surgery, Skejby Sygehus, Aarhus University Hospital, Denmark.

OBJECTIVES. This study investigated the velocity distribution across the natural mitral valve. BACKGROUND. Information about the blood velocity distribution across the mitral valve is of interest in basic fluid dynamic studies of the natural mitral valve and is needed for precise cardiac output estimates by Doppler echocardiography. METHODS. The velocity distribution across the mitral valve was measured by epicardial Doppler echocardiography in ten 90-kg anesthetized pigs. By rotating the ultrasound transducer in 30 degrees intervals from the apical position, we constructed two-dimensional velocity profiles across the left ventricular inflow tract from diameters from each rotation arranged around a reference point. The time-averaged mitral velocity profile was calculated to estimate the error in cardiac output calculations that may occur with pulsed Doppler ultrasound when a single sample volume is used to record the mean velocity across the mitral orifice. RESULTS. The time-averaged diastolic cross-sectional mitral velocity profiles at the level of the mitral annulus and leaflet tips were variably skewed because of the development of a large anterior vortex in the left ventricle during the deceleration of early diastolic inflow and atrial systole. The ratio of the time-velocity integral of the center sample volume to the spatially averaged time-velocity integral was 1.13 +/- 0.15 (mean +/- SD) (range 0.80 to 1.32). Using regression analysis, we found a correlation between the degree of nonuniformity of the cross-sectional velocity distribution and the peak velocity of the anterior vortex (r = 0.65, p < 0.01). CONCLUSIONS. The assumption of a flat mean velocity profile across the mitral valve can introduce errors of +13 +/- 15% (mean +/- SD) in cardiac output measured with pulsed Doppler ultrasound when one is interrogating a single center sample volume.

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