Advertisement

Click here for more guidelines.

 
 




CME Topic Collections Past Issues Search Current Issue Home
     

J Am Coll Cardiol, 1994; 23:146-153
© 1994 by the American College of Cardiology Foundation
This Article
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lauer, B
Right arrow Articles by Strauer, B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lauer, B
Right arrow Articles by Strauer, B.

Autoantibodies against human ventricular myosin in sera of patients with acute and chronic myocarditis

B Lauer, K Padberg, HP Schultheiss, and BE Strauer

Medizinische Klinik B, Abteilung fur Kardiologie, Pneumologie und Angiologie, University of Dusseldorf, Germany.

OBJECTIVES. The present study investigated the presence of antimyosin autoantibodies in sera of patients with myocarditis and in three control groups: healthy blood donors, patients with alcoholic cardiomyopathy and patients with other cardiac diseases. BACKGROUND. An increasing body of evidence indicates that in the course of myocarditis, autoimmunologic mechanisms may play a pathogenetic role. Animal studies with Coxsackie B3 virus-induced murine myocarditis could demonstrate the appearance of circulating autoantibodies against cardiac myosin. METHODS. Sera were analyzed by enzyme-linked immunosorbent assay (ELISA) and Western blot with human left ventricular myosin as antigen. RESULTS. Seventeen (42%) of 40 serum samples from patients with myocarditis showed antibody-binding against myosin, whereas only 1 (2.5%) of 39 samples from healthy blood donors and 9 (21%) of 43 samples from patients with other cardiac diseases showed autoantibodies against myosin (p < 0.05 vs. myocarditis). In sera from patients with alcoholic cardiomyopathy (n = 12), no antibodies against human ventricular myosin could be detected. In Western blots, the antimyosin antibodies in patients with myocarditis bound to the myosin heavy chain. Using protein-A sepharose chromatography, it could be shown that the antimyosin autoantibodies are of the immunoglobulin G (IgG) type. In ELISA, the antimyosin autoantibodies bind equally to myosin prepared from either cardiac or skeletal muscle, respectively. CONCLUSIONS. These results demonstrate the presence of autoantibodies against human ventricular myosin in patients with myocarditis. The prevalence of these autoantibodies is significantly higher in patients with myocarditis than in patients with other cardiac diseases. No organ specificity of the autoantibodies could be detected.


This article has been cited by other articles:


Home page
J. Immunol.Home page
Y. Li, J. S. Heuser, L. C. Cunningham, S. D. Kosanke, and M. W. Cunningham
Mimicry and Antibody-Mediated Cell Signaling in Autoimmune Myocarditis
J. Immunol., December 1, 2006; 177(11): 8234 - 8240.
[Abstract] [Full Text] [PDF]


Home page
FASEB J.Home page
R. S. Warraich, E. Griffiths, A. Falconar, V. Pabbathi, C. Bell, G. Angelini, M.-S. Suleiman, and M. H. Yacoub
Human cardiac myosin autoantibodies impair myocyte contractility: a cause-and-effect relationship
FASEB J, April 1, 2006; 20(6): 651 - 660.
[Abstract] [Full Text] [PDF]


Home page
Circ. Res.Home page
H. Futamatsu, J.-i. Suzuki, S. Mizuno, N. Koga, S. Adachi, H. Kosuge, Y. Maejima, K. Hirao, T. Nakamura, and M. Isobe
Hepatocyte Growth Factor Ameliorates the Progression of Experimental Autoimmune Myocarditis: A Potential Role for Induction of T Helper 2 Cytokines
Circ. Res., April 29, 2005; 96(8): 823 - 830.
[Abstract] [Full Text] [PDF]


Home page
Cardiovasc ResHome page
R. W. Azuma, J.-i. Suzuki, M. Ogawa, H. Futamatsu, N. Koga, Y. Onai, H. Kosuge, and M. Isobe
HMG-CoA reductase inhibitor attenuates experimental autoimmune myocarditis through inhibition of T cell activation
Cardiovasc Res, December 1, 2004; 64(3): 412 - 420.
[Abstract] [Full Text] [PDF]


Home page
J. Immunol.Home page
J. A. Taylor, E. Havari, M. F. McInerney, R. Bronson, K. W. Wucherpfennig, and M. A. Lipes
A Spontaneous Model for Autoimmune Myocarditis Using the Human MHC Molecule HLA-DQ8
J. Immunol., February 15, 2004; 172(4): 2651 - 2658.
[Abstract] [Full Text] [PDF]


Home page
Cardiovasc ResHome page
H. Futamatsu, J.-i. Suzuki, H. Kosuge, O. Yokoseki, M. Kamada, H. Ito, M. Inobe, M. Isobe, and T. Uede
Attenuation of experimental autoimmune myocarditis by blocking activated T cells through inducible costimulatory molecule pathway
Cardiovasc Res, July 1, 2003; 59(1): 95 - 104.
[Abstract] [Full Text] [PDF]


Home page
Eur J Heart FailHome page
A. L.P. Caforio, N. J. Mahon, F. Tona, and W. J. McKenna
Circulating cardiac autoantibodies in dilated cardiomyopathy and myocarditis: pathogenetic and clinical significance
Eur J Heart Fail, August 1, 2002; 4(4): 411 - 417.
[Abstract] [Full Text] [PDF]


Home page
J Am Coll CardiolHome page
Y. Wang, M. Afanasyeva, S. L. Hill, Z. Kaya, and N. R. Rose
Nasal administration of cardiac myosin suppresses autoimmune myocarditis in mice
J. Am. Coll. Cardiol., November 15, 2000; 36(6): 1992 - 1999.
[Abstract] [Full Text] [PDF]


Home page
Infect. Immun.Home page
S. Malkiel, L. Liao, M. W. Cunningham, and B. Diamond
T-Cell-Dependent Antibody Response to the Dominant Epitope of Streptococcal Polysaccharide, N-Acetyl-Glucosamine, Is Cross-Reactive with Cardiac Myosin
Infect. Immun., October 1, 2000; 68(10): 5803 - 5808.
[Abstract] [Full Text] [PDF]


Home page
J Am Coll CardiolHome page
B. Lauer, M. Schannwell, U. Kuhl, B.-E. Strauer, and H.-P. Schultheiss
Antimyosin autoantibodies are associated with deterioration of systolic and diastolic left ventricular function in patients with chronic myocarditis
J. Am. Coll. Cardiol., January 1, 2000; 35(1): 11 - 18.
[Abstract] [Full Text] [PDF]


Home page
J Am Coll CardiolHome page
U. Kuhl, B. Lauer, M. Souvatzoglu, H. Vosberg, and H.-P. Schultheiss
Antimyosin scintigraphy and immunohistologic analysis of endomyocardial biopsy in patients with clinically suspected myocarditis--evidence of myocardial cell damage and inflammation in the absence of histologic signs of myocarditis
J. Am. Coll. Cardiol., November 1, 1998; 32(5): 1371 - 1376.
[Abstract] [Full Text] [PDF]


Home page
HeartHome page
P F Currie, J H Goldman, A L P Caforio, A J Jacob, M K Baig, R P Brettle, A J Haven, N A Boon, and W J McKenna
Cardiac autoimmunity in HIV related heart muscle disease
Heart, June 1, 1998; 79(6): 599 - 604.
[Abstract] [Full Text]


Home page
CirculationHome page
D. M. McNamara, W. D. Rosenblum, K. M. Janosko, M. K. Trost, F. S. Villaneuva, A.J. Demetris, S. Murali, and A. M. Feldman
Intravenous Immune Globulin in the Therapy of Myocarditis and Acute Cardiomyopathy
Circulation, June 3, 1997; 95(11): 2476 - 2478.
[Abstract] [Full Text]


Home page
CirculationHome page
H. Takada, C. Kishimoto, and Y. Hiraoka
Therapy With Immunoglobulin Suppresses Myocarditis in a Murine Coxsackievirus B3 Model : Antiviral and Anti-inflammatory Effects
Circulation, September 15, 1995; 92(6): 1604 - 1611.
[Abstract] [Full Text]



 
  CME Topic Collections Past Issues Search Current Issue Home

Advertisement