|
|
||||||||||
|
J Am Coll Cardiol, 1993; 22:642-647 © 1993 by the American College of Cardiology Foundation |
Department of Internal Medicine, University of Iowa College of Medicine, Iowa City 52242.
OBJECTIVES. This study was performed to determine the acute effect of cigarette smoking on proximal and distal epicardial conduit and coronary resistance vessels. BACKGROUND. Cigarette smoking causes constriction of epicardial arteries and a decrease in coronary blood flow in patients with coronary artery disease, despite an increase in myocardial oxygen demand. The role of changes in resistance vessel tone in the acute coronary hemodynamic effect of smoking has not been examined. METHODS. Twenty-four long-term smokers were studied during cardiac catheterization after vasoactive medications had been discontinued. The effect of smoking one cigarette 10 to 15 mm long on proximal and distal conduit vessel segments was assessed before and immediately after smoking and at 5, 15 and 30 min after smoking (n = 8). To determine the effect of smoking on resistance vessels, coronary flow velocity was measured in a nonobstructed artery with a 3F intracoronary Doppler catheter before and for 5 min after smoking (n = 8). Eight patients were studied without smoking to control for spontaneous changes in conduit arterial diameter (n = 5) and resistance vessel tone (n = 3). RESULTS. The average diameter of proximal coronary artery segments decreased from 2.56 +/- 0.12 mm (mean +/- SEM) before smoking to 2.41 +/- 0.09 mm 5 min after smoking (-5 +/- 2%, p < 0.05). Distal coronary diameter decreased from 1.51 +/- 0.07 to 1.39 +/- 0.06 mm (-8 +/- 2%, p < 0.01). Marked focal vasoconstriction after smoking was observed in two patients. Coronary diameter returned to baseline by 30 min after smoking. There was no change in vessel diameter in control patients. Despite a significant increase in the heart rate-mean arterial pressure product, coronary flow velocity decreased by 7 +/- 4% (p < 0.05) and coronary vascular resistance increased by 21 +/- 4% (p < 0.01) 5 min after smoking. There was no change in these variables in the control subjects. CONCLUSIONS. Smoking causes immediate constriction of proximal and distal epicardial coronary arteries and an increase in coronary resistance vessel tone, despite an increase in myocardial oxygen demand. These acute coronary hemodynamic effects may contribute to the adverse cardiovascular consequences of cigarette smoking.
This article has been cited by other articles:
![]() |
I. Barutcu, A. M. Esen, D. Kaya, E. Onrat, M. Melek, A. Celik, C. Kilit, M. Turkmen, O. Karakaya, O. B. Esen, et al. Effect of Acute Cigarette Smoking on Left and Right Ventricle Filling Parameters: A Conventional and Tissue Doppler Echocardiographic Study in Healthy Participants Angiology, July 1, 2008; 59(3): 312 - 316. [Abstract] [PDF] |
||||
![]() |
O. Karakaya, I. Barutcu, D. Kaya, A. M. Esen, M. Saglam, M. Melek, E. Onrat, M. Turkmen, O. B. Esen, and C. Kaymaz Acute Effect of Cigarette Smoking on Heart Rate Variability Angiology, November 1, 2007; 58(5): 620 - 624. [Abstract] [PDF] |
||||
![]() |
H. Gullu, M. Caliskan, O. Ciftci, D. Erdogan, S. Topcu, E. Yildirim, A. Yildirir, and H. Muderrisoglu Light cigarette smoking impairs coronary microvascular functions as severely as smoking regular cigarettes Heart, October 1, 2007; 93(10): 1274 - 1277. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Tsuchiya, E. F. Sato, M. Inoue, and A. Asada Acupuncture Enhances Generation of Nitric Oxide and Increases Local Circulation Anesth. Analg., February 1, 2007; 104(2): 301 - 307. [Abstract] [Full Text] [PDF] |
||||
![]() |
H. K. Reddy, S. K. G. Koshy, S. Wasson, E. E. Quan, S. Pagni, A. M. Roberts, I. G. Joshua, and S. C. Tyagi Adaptive-Outward and Maladaptive-Inward Arterial Remodeling Measured by Intravascular Ultrasound in Hyperhomocysteinemia and Diabetes Journal of Cardiovascular Pharmacology and Therapeutics, March 1, 2006; 11(1): 65 - 77. [Abstract] [PDF] |
||||
![]() |
P. C. Strike and A. Steptoe Behavioral and Emotional Triggers of Acute Coronary Syndromes: A Systematic Review and Critique Psychosom Med, March 1, 2005; 67(2): 179 - 186. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. Tsiara, M. Elisaf, and D. P. Mikhailidis Influence of Smoking on Predictors of Vascular Disease Angiology, September 1, 2003; 54(5): 507 - 530. [Abstract] [PDF] |
||||
![]() |
J. L. Houghton, D. S. Strogatz, M. T. Torosoff, V. E. Smith, S. A. Fein, P. A. Kuhner, E. F. Philbin, and A. A. Carr African Americans With LVH Demonstrate Depressed Sensitivity of the Coronary Microcirculation to Stimulated Relaxation Hypertension, September 1, 2003; 42(3): 269 - 276. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Tsuchiya, A. Asada, E. Kasahara, E. F. Sato, M. Shindo, and M. Inoue Smoking a Single Cigarette Rapidly Reduces Combined Concentrations of Nitrate and Nitrite and Concentrations of Antioxidants in Plasma Circulation, March 12, 2002; 105(10): 1155 - 1157. [Abstract] [Full Text] [PDF] |
||||
![]() |
T. Neunteufl, S. Heher, K. Kostner, G. Mitulovic, S. Lehr, G. Khoschsorur, R. W. Schmid, G. Maurer, and T. Stefenelli Contribution of nicotine to acute endothelial dysfunction in long-term smokers J. Am. Coll. Cardiol., January 16, 2002; 39(2): 251 - 256. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. L. Houghton, T. A. Pearson, R. G. Reed, M. T. Torosoff, N. L. Henches, P. A. Kuhner, and E. F. Philbin Cholesterol Lowering With Pravastatin Improves Resistance Artery Endothelial Function : Report of Six Subjects With Normal Coronary Arteriograms Chest, September 1, 2000; 118(3): 756 - 760. [Abstract] [Full Text] [PDF] |
||||
![]() |
A G Violaris, A Thury, E Regar, R Melkert, and P W Serruys Influence of a history of smoking on short term (six month) clinical and angiographic outcome after successful coronary angioplasty Heart, September 1, 2000; 84(3): 299 - 306. [Abstract] [Full Text] [PDF] |
||||
![]() |
T.-M. Lee, S.-F. Su, M.-F. Chen, and C.-H. Tsai Acute effects of urinary bladder distention on the coronary circulation in patients with early atherosclerosis J. Am. Coll. Cardiol., August 1, 2000; 36(2): 453 - 460. [Abstract] [Full Text] [PDF] |
||||
![]() |
K. Wilson, N. Gibson, A. Willan, and D. Cook Effect of Smoking Cessation on Mortality After Myocardial Infarction: Meta-analysis of Cohort Studies Arch Intern Med, April 10, 2000; 160(7): 939 - 944. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. J. Hutchison, K. Sudhir, R. E. Sievers, B.-Q. Zhu, Y.-P. Sun, T. M. Chou, K. Chatterjee, P. C. Deedwania, J. P. Cooke, S. A. Glantz, et al. Effects of L-Arginine on Atherogenesis and Endothelial Dysfunction due to Secondhand Smoke Hypertension, July 1, 1999; 34(1): 44 - 50. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. J. Hutchison, S. A. Glantz, B.-Q. Zhu, Y.-P. Sun, T. M. Chou, K. Chatterjee, P. C. Deedwania, W. W. Parmley, and K. Sudhir In-utero and neonatal exposure to secondhand smoke causes vascular dysfunction in newborn rats J. Am. Coll. Cardiol., November 1, 1998; 32(5): 1463 - 1467. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. Sugiyama, K. Kugiyama, M. Ohgushi, T. Matsumura, Y. Ota, H. Doi, N. Ogata, H. Oka, and H. Yasue Supersensitivity of atherosclerotic artery to constrictor effect of cigarette smoke extract Cardiovasc Res, May 1, 1998; 38(2): 508 - 515. [Abstract] [Full Text] [PDF] |
||||
![]() |
T. Motoyama, H. Kawano, K. Kugiyama, O. Hirashima, M. Ohgushi, M. Yoshimura, H. Ogawa, and H. Yasue Endothelium-dependent vasodilation in the brachial artery is impaired in smokers: effect of vitamin C Am J Physiol Heart Circ Physiol, October 1, 1997; 273(4): H1644 - H1650. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. Schmermund, D. Baumgart, G. Gorge, R. Seibel, D. Gronemeyer, J. Ge, M. Haude, J. Rumberger, and R. Erbel Coronary Artery Calcium in Acute Coronary Syndromes : A Comparative Study of Electron-Beam Computed Tomography, Coronary Angiography, and Intracoronary Ultrasound in Survivors of Acute Myocardial Infarction and Unstable Angina Circulation, September 2, 1997; 96(5): 1461 - 1469. [Abstract] [Full Text] |
||||
![]() |
J. L. Houghton, V. E. Smith, D. S. Strogatz, N. L. Henches, W. M. Breisblatt, and A. A. Carr Effect of African-American Race and Hypertensive Left Ventricular Hypertrophy on Coronary Vascular Reactivity and Endothelial Function Hypertension, March 1, 1997; 29(3): 706 - 714. [Abstract] [Full Text] |
||||
![]() |
W. M. Chilian Coronary Microcirculation in Health and Disease: Summary of an NHLBI Workshop Circulation, January 21, 1997; 95(2): 522 - 528. [Abstract] [Full Text] |
||||
![]() |
C. Stefanadis, E. Tsiamis, C. Vlachopoulos, C. Stratos, K. Toutouzas, C. Pitsavos, S. Marakas, H. Boudoulas, and P. Toutouzas Unfavorable Effect of Smoking on the Elastic Properties of the Human Aorta Circulation, January 7, 1997; 95(1): 31 - 38. [Abstract] [Full Text] |
||||
![]() |
T. Heitzer, S. Yla-Herttuala, J. Luoma, S. Kurz, T. Munzel, H. Just, M. Olschewski, and H. Drexler Cigarette Smoking Potentiates Endothelial Dysfunction of Forearm Resistance Vessels in Patients With Hypercholesterolemia : Role of Oxidized LDL Circulation, April 1, 1996; 93(7): 1346 - 1353. [Abstract] [Full Text] |
||||
![]() |
A. M. Zeiher, V. Schachinger, and J. Minners Long-term Cigarette Smoking Impairs Endothelium-Dependent Coronary Arterial Vasodilator Function Circulation, September 1, 1995; 92(5): 1094 - 1100. [Abstract] [Full Text] |
||||
![]() |
J. Czernin, K. Sun, R. Brunken, M. Bottcher, M. Phelps, and H. Schelbert Effect of Acute and Long-term Smoking on Myocardial Blood Flow and Flow Reserve Circulation, June 15, 1995; 91(12): 2891 - 2897. [Abstract] [Full Text] |
||||
![]() |
C. L. Grines, E. J. Topol, W. W. O'Neill, B. S. George, D. Kereiakes, H. R. Phillips, J. D. Leimberger, L. H. Woodlief, and R. M. Califf Effect of Cigarette Smoking on Outcome After Thrombolytic Therapy for Myocardial Infarction Circulation, January 15, 1995; 91(2): 298 - 303. [Abstract] [Full Text] |
||||
![]() |
D. J. Moliterno, J. E. Willard, R. A. Lange, B. H. Negus, J. D. Boehrer, D. B. Glamann, C. Landau, J. D. Rossen, M. D. Winniford, and L. D. Hillis Coronary-Artery Vasoconstriction Induced by Cocaine, Cigarette Smoking, or Both N. Engl. J. Med., February 17, 1994; 330(7): 454 - 459. [Abstract] [Full Text] |
||||
| HOME | SUBSCRIPTIONS | CURRENT ISSUE | PAST ISSUES | CARDIOSOURCE | SEARCH | HELP | FEEDBACK |