JACC
HOME SUBSCRIPTIONS CURRENT ISSUE PAST ISSUES CARDIOSOURCE SEARCH HELP FEEDBACK
QUICK SEARCH:   [advanced]


     

J Am Coll Cardiol, 1993; 21:1454-1460
© 1993 by the American College of Cardiology Foundation
This Article
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Krogmann, O.
Right arrow Articles by Bourgeois, M
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Krogmann, O.
Right arrow Articles by Bourgeois, M

Left ventricular diastolic dysfunction late after coarctation repair in childhood: influence of left ventricular hypertrophy

ON Krogmann, S Rammos, M Jakob, WJ Corin, OM Hess, and M Bourgeois

Department of Pediatric Cardiology, Heinrich-Heine University, Dusseldorf, Germany.

OBJECTIVES. Left ventricular systolic and diastolic function were evaluated late after successful operation for aortic coarctation in childhood. BACKGROUND. Persistent arterial hypertension and left ventricular hypertrophy after coarctation repair might impair left ventricular function. METHODS. Biplane angiography and simultaneous high fidelity pressure measurements were performed in 12 patients 3 to 12 years postoperatively (residual pressure gradient 4 mm Hg). Eight patients were normotensive and four had borderline hypertension. Data at rest and after nitroprusside infusion (1.7 micrograms/kg per min) were evaluated and compared with data from 12 control subjects. RESULTS. Systolic left ventricular function (ejection fraction-end-systolic wall stress relation) was normal in all patients. However, left ventricular muscle mass (113 vs. 86 g/m2), right atrial pressure (5.2 vs. 1.9 mm Hg) and left ventricular end-diastolic pressure (16 vs. 11 mm Hg) were significantly higher in patients than in control subjects. There was a linear relation between muscle mass and left ventricular end-diastolic (r = 0.66, p < 0.001) or right atrial (r = 0.60, p < 0.01) pressure. Left ventricular relaxation and myocardial stiffness were normal. However, there was an upward shift of the diastolic pressure-volume curve when compared with control values, but this shift was reversed by the administration of nitroprusside. CONCLUSIONS. Systolic function is normal late after coarctation repair. However, diastolic function can be abnormal with an upward shift of the diastolic pressure-volume curve that is reversed by nitroprusside administration and is probably due to residual left ventricular hypertrophy.


This article has been cited by other articles:


Home page
 J Am Coll CardiolHome page
B. Lauer, M. Schannwell, U. Kuhl, B.-E. Strauer, and H.-P. Schultheiss
Antimyosin autoantibodies are associated with deterioration of systolic and diastolic left ventricular function in patients with chronic myocarditis
J. Am. Coll. Cardiol., January 1, 2000; 35(1): 11 - 18.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
W. J Paulus and A. M Shah
NO and cardiac diastolic function
Cardiovasc Res, August 15, 1999; 43(3): 595 - 606.
[Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
A. Banerjee, A. M. Mendelsohn, T. K. Knilans, R. A. Meyer, and D. C. Schwartz
Effect of myocardial hypertrophy on systolic and diastolic function in children: insights from the force-frequency and relaxation-frequency relationships
J. Am. Coll. Cardiol., October 1, 1998; 32(4): 1088 - 1095.
[Abstract] [Full Text] [PDF]


HOME SUBSCRIPTIONS CURRENT ISSUE PAST ISSUES CARDIOSOURCE SEARCH HELP FEEDBACK
Copyright © 1993 by the American College of Cardiology Foundation.