|
| HOME | SUBSCRIPTIONS | CURRENT ISSUE | PAST ISSUES | CARDIOSOURCE | SEARCH | HELP | FEEDBACK |
|
|
|
|||||||||
|
|||||||||||
|
J Am Coll Cardiol, 1993; 21:783-797 © 1993 by the American College of Cardiology Foundation |
University of Texas Medical School, Houston 77030.
OBJECTIVES. To obtain the size of regional myocardial mass for individual coronary arteries in vivo. BACKGROUND. The anatomic site of occlusion in a coronary artery does not predict the size of the risk area because location of the occlusion does not account for the size of the artery or of its dependent myocardial bed. METHODS. Intracoronary radiolabeled microspheres were injected and coronary arteriograms were quantitatively analyzed by semiautomated methods. The coronary artery lumen areas and the sum of epicardial coronary artery branch lengths distal to the points where radiomicrospheres had been injected were determined from both in vivo and postmortem coronary arteriograms. Regional myocardial mass distal to the point of each microsphere injection was correlated with corresponding distal summed coronary branch lengths and with coronary artery lumen areas. RESULTS. 1) Regional myocardial mass was closely and linearly related to sum of coronary artery branch lengths distal to any point in the coronary artery tree and therefore could be determined for any location on a coronary arteriogram. 2) The fraction of total left ventricular mass at risk distal to a stenosis could be determined from the corresponding fraction of total coronary artery tree length independently of the scale or X-ray magnification used to measure absolute branch lengths. 3) Cross-sectional lumen area at any point in the left coronary artery tree was closely related to the size of the dependent vascular bed with a curvilinear relation similar to that observed in humans with normal coronary arteriograms. CONCLUSIONS. On coronary arteriograms, the anatomic area at risk for myocardial infarction distal to any point in the coronary artery tree can be determined from the sum of distal coronary artery branch lengths. There is a curvilinear relation between coronary artery lumen area and dependent regional myocardial mass comparable to that in humans, reflecting fundamental physical principles underlying the structure of the coronary vascular tree.
This article has been cited by other articles:
|
|
 |
|
  N. Hadjiloizou, J. E. Davies, I. S. Malik, J. Aguado-Sierra, K. Willson, R. A. Foale, K. H. Parker, A. D. Hughes, D. P. Francis, and J. Mayet Differences in cardiac microcirculatory wave patterns between the proximal left mainstem and proximal right coronary artery Am J Physiol Heart Circ Physiol, September 1, 2008; 295(3): H1198 - H1205. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. S. Choy and G. S. Kassab Scaling of myocardial mass to flow and morphometry of coronary arteries J Appl Physiol, May 1, 2008; 104(5): 1281 - 1286. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. T. Ortiz-Perez, S. N. Meyers, D. C. Lee, P. Kansal, F. J. Klocke, T. A. Holly, C. J. Davidson, R. O. Bonow, and E. Wu Angiographic estimates of myocardium at risk during acute myocardial infarction: validation study using cardiac magnetic resonance imaging Eur. Heart J., July 2, 2007; 28(14): 1750 - 1758. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. F. De Marchi, P. Meier, P. Oswald, and C. Seiler Variable ECG signs of ischemia during controlled occlusion of the left and right coronary artery in humans Am J Physiol Heart Circ Physiol, July 1, 2006; 291(1): H351 - H356. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. S. Kassab Scaling laws of vascular trees: of form and function Am J Physiol Heart Circ Physiol, February 1, 2006; 290(2): H894 - H903. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. F. de Marchi, P. Oswald, S. Windecker, B. Meier, and C. Seiler Reciprocal relationship between left ventricular filling pressure and the recruitable human coronary collateral circulation Eur. Heart J., March 2, 2005; 26(6): 558 - 566. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C Seiler, T Pohl, E Lipp, D Hutter, and B Meier Regional left ventricular function during transient coronary occlusion: relation with coronary collateral flow Heart, July 1, 2002; 88(1): 35 - 42. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Pohl, C. Seiler, M. Billinger, E. Herren, K. Wustmann, H. Mehta, S. Windecker, F. R. Eberli, and B. Meier Frequency distribution of collateral flow and factors influencing collateral channel development: Functional collateral channel measurement in 450 patients with coronary artery disease J. Am. Coll. Cardiol., December 1, 2001; 38(7): 1872 - 1878. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Molloi, G. S. Kassab, and Y. Zhou Quantification of Coronary Artery Lumen Volume by Digital Angiography: In Vivo Validation Circulation, November 6, 2001; 104(19): 2351 - 2357. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Taki, S. Fujino, K. Nakajima, I. Matsunari, H. Okazaki, T. Saga, H. Bunko, and N. Tonami 99mTc-Sestamibi Retention Characteristics During Pharmacologic Hyperemia in Human Myocardium: Comparison with Coronary Flow Reserve Measured by Doppler Flowire J. Nucl. Med., October 1, 2001; 42(10): 1457 - 1463. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. V. Anderson, M. J. Stokes, M. Leon, S. A. Abu-Halawa, Y. Stuart, and R. L. Kirkeeide Coronary Artery Flow Velocity Is Related To Lumen Area and Regional Left Ventricular Mass Circulation, July 4, 2000; 102(1): 48 - 54. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Billinger, M. Fleisch, F. R. Eberli, A. Garachemani, B. Meier, and C. Seiler Is the development of myocardial tolerance to repeated ischemia in humans due to preconditioning or to collateral recruitment? J. Am. Coll. Cardiol., March 15, 1999; 33(4): 1027 - 1035. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Senti, M. Fleisch, M. Billinger, B. Meier, and C. Seiler Long-term physical exercise and quantitatively assessed human coronary collateral circulation J. Am. Coll. Cardiol., July 1, 1998; 32(1): 49 - 56. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. D. Miller, T. J. Donohue, T. L. Wolford, M. J. Kern, S. R. Bergmann, C. M. Mechem, and J. J. Hartman Assessment of Blood Flow Distal to Coronary Artery Stenoses: Correlations Between Myocardial Positron Emission Tomography and Poststenotic Intracoronary Doppler Flow Reserve Circulation, November 15, 1996; 94(10): 2447 - 2454. [Abstract] [Full Text]
|
|
|
|
|
|
S. Molloi, A. Ersahin, J. Tang, J. Hicks, and C. Y. Leung Quantification of Volumetric Coronary Blood Flow With Dual-Energy Digital Subtraction Angiography Circulation, May 15, 1996; 93(10): 1919 - 1927. [Abstract] [Full Text]
|
|
|
|
|
|
C. M. Gibson, C. P. Cannon, W. L. Daley, J. T. Dodge Jr, B. Alexander, S. J. Marble, C. H. McCabe, L. Raymond, T. Fortin, W. K. Poole, et al. TIMI Frame Count : A Quantitative Method of Assessing Coronary Artery Flow Circulation, March 1, 1996; 93(5): 879 - 888. [Abstract] [Full Text]
|
|
|
|
|
|
R. F. Redberg, Y. Sobol, T. M. Chou, M. Malloy, S. Kumar, E. Botvinick, and J. Kane Adenosine-Induced Coronary Vasodilatation During Transesophageal Doppler Echocardiography : Rapid and Safe Measurement of Coronary Flow Reserve Ratio Can Predict Significant Left Anterior Descending Coronary Stenosis Circulation, July 15, 1995; 92(2): 190 - 196. [Abstract] [Full Text]
|
|
|
|
|
|
B. De Bruyne, J. Bartunek, S. U. Sys, and G. R. Heyndrickx Relation Between Myocardial Fractional Flow Reserve Calculated From Coronary Pressure Measurements and Exercise-Induced Myocardial Ischemia Circulation, July 1, 1995; 92(1): 39 - 46. [Abstract] [Full Text]
|
|
| HOME | SUBSCRIPTIONS | CURRENT ISSUE | PAST ISSUES | CARDIOSOURCE | SEARCH | HELP | FEEDBACK |
