Left ventricular flow propagation during early filling is related to wall relaxation: a color M-mode Doppler analysis

Unite de Recherche U. 2 de l'Institut National de la Sante et de la Recherche Medicale, Creteil, France.

OBJECTIVES. This study was designed to evaluate the relation between the velocity of flow propagation and left ventricular relaxation by using color M-mode Doppler echocardiography to analyze flow propagation in the left ventricle. BACKGROUND. Noninvasive attempts to identify alterations in left ventricular relaxation have been hampered because both the relaxation rate and left atrial filling pressure are the determinants of peak early velocity and filling rate. METHODS. Color M-mode velocity data were transferred to a microcomputer and compared with conventional pulsed Doppler data to assess the ability of color M-mode echocardiography to analyze velocity field properties. The velocity of flow propagation was measured as the slope of the flow wave front during early filling in normal subjects (n = 29) and in patients with disease that alters relaxation (dilated cardiomyopathy [n = 31], ischemic cardiomyopathy [n = 8], hypertrophic cardiomyopathy [n = 5], systemic hypertension [n = 22] and aortic valve disease [n = 25]). In nine patients with end-stage dilated cardiomyopathy, echocardiographic and left heart catheterization data were obtained at baseline and during intracoronary dobutamine infusion. RESULTS. Color M-mode and pulsed Doppler echocardiographic data were highly correlated (n = 217, r = 0.94, p less than 0.0001, velocity range 0.2 to 1.5 m/s). The velocity of flow propagation was lower in patients than in normal subjects (0.46 +/- 0.15 vs. 0.84 +/- 0.11 m/s, p less than 0.0001). The decrease was significant in all disease forms with or without left ventricular dilation. The velocity of flow propagation was related to peak early velocity in normal subjects (p less than 0.001) but not in patients. It varied inversely with the isovolumetric relaxation time constant during dobutamine infusion and the two variables were highly correlated (p less than 0.0001). CONCLUSIONS. The velocity of flow propagation during early filling seems to be highly dependent on the left ventricular relaxation rate and could be an important tool in studying diastolic function.

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				K. Steine, M. Stugaard, and O. A. Smiseth Mechanisms of Retarded Apical Filling in Acute Ischemic Left Ventricular Failure Circulation, April 20, 1999; 99(15): 2048 - 2054. [Abstract] [Full Text] [PDF]

				S. F. Nagueh, N. M. Lakkis, K. J. Middleton, W. H. Spencer III, W. A. Zoghbi, and M. A. Quinones Doppler Estimation of Left Ventricular Filling Pressures in Patients With Hypertrophic Cardiomyopathy Circulation, January 19, 1999; 99(2): 254 - 261. [Abstract] [Full Text] [PDF]

				M. J. Garcia, J. D. Thomas, and A. L. Klein New Doppler echocardiographic applications for the study of diastolic function J. Am. Coll. Cardiol., October 1, 1998; 32(4): 865 - 875. [Abstract] [Full Text] [PDF]

				O. A. Smiseth, K. Steine, G. Sandbak, M. Stugaard, and T. O. Gjolberg Mechanics of intraventricular filling: study of LV early diastolic pressure gradients and flow velocities Am J Physiol Heart Circ Physiol, September 1, 1998; 275(3): H1062 - H1069. [Abstract] [Full Text] [PDF]

				Y. Otsuji, D. Gilon, L. Jiang, S. He, M. Leavitt, M. J. Roy, M. J. Birmingham, and R. A. Levine Restricted diastolic opening of the mitral leaflets in patients with left ventricular dysfunction: evidence for increased valve tethering J. Am. Coll. Cardiol., August 1, 1998; 32(2): 398 - 404. [Abstract] [Full Text] [PDF]

				S. F. Nagueh, H. A. Kopelen, and M. A. Quinones Assessment of Left Ventricular Filling Pressures by Doppler in the Presence of Atrial Fibrillation Circulation, November 1, 1996; 94(9): 2138 - 2145. [Abstract] [Full Text]

				R. S. Vasan, E. J. Benjamin, and D. Levy Congestive Heart Failure With Normal Left Ventricular Systolic Function: Clinical Approaches to the Diagnosis and Treatment of Diastolic Heart Failure Arch Intern Med, January 22, 1996; 156(2): 146 - 157. [Abstract] [PDF]