Right ventricular function in valvular heart disease: relation to pulmonary artery pressure
R Grose,
J Strain,
and
T Yipintosoi
Right ventricular angiography was performed in 46 patients with acquired valvular heart disease and 8 normal subjects. Right ventricular ejection fraction (RVEF) correlated highly only with right ventricular peak systolic pressure (RVPSP) and mean pulmonary artery pressure, both in patients with and without tricuspid insufficiency. For the group, RVEF = -0.33 RVPSP + 63 (correlation coefficient [r] = -0.76, probability [p] less than 0.001). Of 20 patients with moderate or severe elevation of pulmonary artery pressure, 17 (85%) had an abnormally low ejection fraction (less than 47%), while 19 (73%) of 26 patients with normal or mildly elevated pulmonary artery pressure had a normal right ventricular ejection fraction. In seven patients with elevated pulmonary artery pressure, a second ventriculogram was performed during intravenous nitroglycerin administration. Nitroglycerin produced a significant decrease in right ventricular peak systolic pressure (59 +/- 22 to 49 +/- 18 mm Hg, mean +/- standard deviation) (p less than 0.05) and in end-systolic volume (71 +/- 16 to 59 +/- 11 m1/m2) (p less than 0.05), and an increase in ejection fraction (43 +/- 9 to 48 +/- 7%) (p less than 0.05). Thus, at least part of the depression of ejection fraction in patients with elevated pulmonary pressure is reversible with a decrease in pulmonary artery pressure.
This article has been cited by other articles:
|
|
|
|
 
Y. Tayyareci, Y. Nisanci, B. Umman, A. Oncul, S. Yurdakul, I. Altun, S. Umman, and Z. Bugra
Early detection of right ventricular systolic dysfunction by using myocardial acceleration during isovolumic contraction in patients with mitral stenosis
Eur Heart J Cardiovasc Imaging,
July 1, 2008;
9(4):
516 - 521.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. G. Fischer, H. V. Aken, and H. Burkle
Management of Pulmonary Hypertension: Physiological and Pharmacological Considerations for Anesthesiologists
Anesth. Analg.,
June 1, 2003;
96(6):
1603 - 1616.
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Le Tourneau, D. Grandmougin, C. Foucher, E. P. McFadden, P. de Groote, A. Prat, H. Warembourg, and G. Deklunder
Anterior Chordal Transection Impairs Not Only Regional Left Ventricular Function But Also Regional Right Ventricular Function in Mitral Regurgitation
Circulation,
September 18, 2001;
104(2009):
I-41 - I-46.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J Meluzin, L Spinarova, J Bakala, J Toman, J Krejci, P Hude, T Kara, and M Soucek
Pulsed Doppler tissue imaging of the velocity of tricuspid annular systolic motion. A new, rapid, and non-invasive method of evaluating right ventricular systolic function
Eur. Heart J.,
February 2, 2001;
22(4):
340 - 348.
[Abstract]
[PDF]
|
|
|
|
|
|
|
C. E. Reed, F. G. Spinale, and F. A. Crawford
Effect of pulmonary resection on right ventricular function
Ann. Thorac. Surg.,
April 1, 1992;
53(4):
578 - 582.
[Abstract]
[PDF]
|
|
|
|
|
|
|
J. C. Mullen, S. E. Fremes, R. D. Weisel, G. T. Christakis, J. Ivanov, M. M. Madonik, S. Houle, and P. R. McLaughlin
Right Ventricular Function: A Comparison Between Blood and Crystalloid Cardioplegia
Ann. Thorac. Surg.,
January 1, 1987;
43(1):
17 - 24.
[Abstract]
[PDF]
|
|
|
|
